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transgenic Tg2576 mouse brain.","volume":"27","author":"S Burger","year":"2009","journal-title":"Int J Dev Neurosci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jns.2009.02.318","article-title":"VEGF genetic variability is associated with increased risk of developing Alzheimer&apos;s disease.","volume":"283","author":"R Del Bo","year":"2009","journal-title":"J Neurol Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1471-4159.2009.06426.x","article-title":"Alzheimer&apos;s beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2.","volume":"112","author":"NS Patel","year":"2010","journal-title":"J Neurochem"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3233\/JAD-2010-1253","article-title":"Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer&apos;s disease and non-demented patients.","volume":"19","author":"X Cheng","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.expneurol.2008.05.007","article-title":"Age-related differences in NFkappaB translocation and Bcl-2\/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons.","volume":"213","author":"JR Patel","year":"2008","journal-title":"Exp Neurol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1023\/A:1022337519035","article-title":"The induction of the TNFalpha death domain signaling pathway in Alzheimer&apos;s disease brain.","volume":"28","author":"M Zhao","year":"2003","journal-title":"Neurochem Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopsych.2010.08.025","article-title":"YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer&apos;s disease.","volume":"68","author":"R Craig-Schapiro","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1073\/pnas.95.6.3227","article-title":"Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function.","volume":"95","author":"Q Guo","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(93)90999-4","article-title":"Calbindin-D28k immunoreactivity and selective vulnerability to ischemia in the dentate gyrus of the developing rat.","volume":"606","author":"JH Goodman","year":"1993","journal-title":"Brain Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0896-6273(91)90120-O","article-title":"Evidence for calcium-reducing and excito-protective roles for the calcium-binding protein calbindin-D28k in cultured hippocampal neurons.","volume":"6","author":"MP Mattson","year":"1991","journal-title":"Neuron"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0026-895X(25)08714-0","article-title":"Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.","volume":"49","author":"JH Prehn","year":"1996","journal-title":"Mol Pharmacol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.87.11.4078","article-title":"Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.","volume":"87","author":"AM Iacopino","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.exger.2003.09.018","article-title":"Chromogranin peptides in Alzheimer&apos;s disease.","volume":"39","author":"T Lechner","year":"2004","journal-title":"Exp 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