{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:31:55Z","timestamp":1790811115695,"version":"4.1.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0019150","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T20:53:29Z","timestamp":1303937609000},"page":"e19150","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Fractal Analysis Reveals Reduced Complexity of Retinal Vessels in CADASIL"],"prefix":"10.1371","volume":"6","author":[{"given":"Michele","family":"Cavallari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Falco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Frontali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Orzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","article-title":"CADASIL.","volume":"8","author":"H Chabriat","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s00415-008-0777-y","article-title":"Virchow-Robin spaces relate to cerebral small vessel disease severity.","volume":"255","author":"RP Rouhl","year":"2008","journal-title":"J Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1172\/JCI39733","article-title":"Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.","volume":"120","author":"A Joutel","year":"2010","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures.","volume":"206","author":"N Patton","year":"2005","journal-title":"J Anat"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/STROKEAHA.110.580837","article-title":"Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study.","volume":"41","author":"H Yatsuya","year":"2010","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(01)06253-5","article-title":"Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study.","volume":"358","author":"TY Wong","year":"2001","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/jama.288.1.67","article-title":"Atheroslerosis Risk in Communities Study. Cerebral white matter lesions, retinopathy, and incident clinical stroke.","volume":"288","author":"TY Wong","year":"2002","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1212\/WNL.0b013e3181b78436","article-title":"Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up study.","volume":"73","author":"SR Lesage","year":"2009","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.ophtha.2006.03.030","article-title":"Ophthalmologic findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a cross-sectional study.","volume":"13","author":"S Roine","year":"2006","journal-title":"Ophthalmology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.bioeng.6.040803.140100","article-title":"Fractal analysis of the vascular tree in the human retina.","volume":"6","author":"BR Masters","year":"2004","journal-title":"Annu Rev Biomed Eng"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/brain\/118.6.1601","article-title":"Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis.","volume":"118","author":"M Filippi","year":"1995","journal-title":"Brain"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/brain\/awg182","article-title":"Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years.","volume":"126","author":"F Bagnato","year":"2003","journal-title":"Brain"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1212\/WNL.0b013e3181d7d8b4","article-title":"Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke.","volume":"74","author":"FN Doubal","year":"2010","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ana.22011","article-title":"Retinal fractals and acute lacunar stroke.","volume":"68","author":"N Cheung","year":"2010","journal-title":"Ann Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1101\/gad.1589207","article-title":"Regulation of vascular morphogenesis by Notch signaling.","volume":"21","author":"C Roca","year":"2007","journal-title":"Genes Dev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0019150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:01:53Z","timestamp":1589032913000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0019150"}},"subtitle":[],"editor":[{"given":"Pablo","family":"Villoslada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0019150","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}