{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:21:32Z","timestamp":1743063692297},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T00:00:00Z","timestamp":1304035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0019197","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T21:27:43Z","timestamp":1304112463000},"page":"e19197","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Altered T Cell Memory and Effector Cell Development in Chronic Lymphatic Filarial Infection That Is Independent of Persistent Parasite Antigen"],"prefix":"10.1371","volume":"6","author":[{"given":"Cathy","family":"Steel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Nutman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1172\/JCI116752","article-title":"Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.","volume":"92","author":"CL King","year":"1993","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/infdis\/173.3.769","article-title":"High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis.","volume":"173","author":"S Mahanty","year":"1996","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.4049\/jimmunol.0904067","article-title":"At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells.","volume":"184","author":"S Metenou","year":"2010","journal-title":"J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1128\/IAI.72.11.6287-6293.2004","article-title":"Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis.","volume":"72","author":"S Specht","year":"2004","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1086\/500472","article-title":"Prenatal T cell immunity to Wuchereria bancrofti and its effect on filarial immunity and infection susceptibility during childhood.","volume":"193","author":"I Malhotra","year":"2006","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(94)90009-4","article-title":"Long-term effect of prenatal exposure to maternal microfilaraemia on immune responsiveness to filarial parasite antigens [see comments].","volume":"343","author":"C Steel","year":"1994","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.4049\/jimmunol.176.7.3885","article-title":"Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection.","volume":"176","author":"S Babu","year":"2006","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.4049\/jimmunol.171.4.1950","article-title":"Brugia malayi microfilariae induce cell death in human dendritic cells, inhibit their ability to make IL-12 and IL-10, and reduce their capacity to activate CD4<sup>+<\/sup> T cells.","volume":"171","author":"RT Semnani","year":"2003","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/1521-4141(200203)32:3<858::AID-IMMU858>3.0.CO;2-E","article-title":"Infection with Brugia microfilariae induces apoptosis of CD4(<sup>+<\/sup>) T lymphocytes: a mechanism of immune unresponsiveness in filariasis.","volume":"32","author":"JS Jenson","year":"2002","journal-title":"Eur J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.176.5.3248","article-title":"Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence.","volume":"176","author":"S Babu","year":"2006","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4049\/jimmunol.170.4.1930","article-title":"CTLA-4 in Filarial Infections: Implications for a Role in Diminished T Cell Reactivity.","volume":"170","author":"C Steel","year":"2003","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/intimm\/dxh375","article-title":"Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activation.","volume":"18","author":"Q Leng","year":"2006","journal-title":"Int Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/978-1-4419-1601-3_7","article-title":"Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62.","volume":"666","author":"W Harnett","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1128\/IAI.71.5.2422-2429.2003","article-title":"Parasite-specific immunomodulatory functions of filarial cystatin.","volume":"71","author":"P Schierack","year":"2003","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4049\/jimmunol.0900257","article-title":"Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria\/malaria-coinfected population.","volume":"183","author":"S Metenou","year":"2009","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1086\/599797","article-title":"Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.","volume":"200","author":"S Babu","year":"2009","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4269\/ajtmh.2007.77.507","article-title":"Effect of diethylcarbamazine on HIV load, CD4%, and CD4\/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial.","volume":"77","author":"NO Nielsen","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(00)03206-2","article-title":"Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10.","volume":"356","author":"AH van den Biggelaar","year":"2000","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1164\/rccm.200211-1320OC","article-title":"Allergic symptoms, atopy, and geohelminth infections in a rural area of ecuador.","volume":"168","author":"PJ Cooper","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1086\/515661","article-title":"Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10.","volume":"178","author":"PJ Cooper","year":"1998","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/infdis\/173.1.269","article-title":"Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni.","volume":"173","author":"EA Sabin","year":"1996","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/IAI.69.3.1574-1580.2001","article-title":"Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR.","volume":"69","author":"PJ Cooper","year":"2001","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.4049\/jimmunol.0903758","article-title":"Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection.","volume":"184","author":"AM Crawley","year":"2010","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.4049\/jimmunol.180.7.4848","article-title":"Age-related dysregulation of CD8<sup>+<\/sup> T cell memory specific for a persistent virus is independent of viral replication.","volume":"180","author":"A Lang","year":"2008","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2249.2008.03610.x","article-title":"Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4<sup>+<\/sup> and CD8<sup>+<\/sup> T cell subsets.","volume":"152","author":"F Mercier","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1084\/jem.20070567","article-title":"Progressive CD4<sup>+<\/sup> central memory T cell decline results in CD4<sup>+<\/sup> effector memory insufficiency and overt disease in chronic SIV infection.","volume":"204","author":"A Okoye","year":"2007","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/rmv.598","article-title":"Cytomegalovirus and human immunosenescence.","volume":"19","author":"G Pawelec","year":"2009","journal-title":"Rev Med Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.coi.2007.06.004","article-title":"CD8 T cell dysfunction during chronic viral infection.","volume":"19","author":"H Shin","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00430-008-0082-5","article-title":"Dynamics of T cell memory in human cytomegalovirus infection.","volume":"197","author":"EC Waller","year":"2008","journal-title":"Med Microbiol Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1073\/pnas.0407192101","article-title":"Antigen-independent memory CD8 T cells do not develop during chronic viral infection.","volume":"101","author":"EJ Wherry","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/intimm\/dxh387","article-title":"Trypanosoma cruzi modulates the profile of memory CD8<sup>+<\/sup> T cells in chronic Chagas&apos; disease patients.","volume":"18","author":"MC Albareda","year":"2006","journal-title":"Int Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e10842","DOI":"10.1371\/journal.pone.0010842","article-title":"Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii.","volume":"5","author":"R Bhadra","year":"2010","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nm1744","article-title":"Drug-induced cure drives conversion to a stable and protective CD8<sup>+<\/sup> T central memory response in chronic Chagas disease.","volume":"14","author":"JM Bustamante","year":"2008","journal-title":"Nat Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.4049\/jimmunol.0901099","article-title":"The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.","volume":"183","author":"D Liu","year":"2009","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/nm1108","article-title":"Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.","volume":"10","author":"C Zaph","year":"2004","journal-title":"Nat Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4049\/jimmunol.177.1.511","article-title":"Persistence and function of central and effector memory CD4<sup>+<\/sup> T cells following infection with a gastrointestinal helminth.","volume":"177","author":"C Zaph","year":"2006","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nm0402-379","article-title":"Memory CD8<sup>+<\/sup> T cells vary in differentiation phenotype in different persistent virus infections.","volume":"8","author":"V Appay","year":"2002","journal-title":"Nat Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/01.aids.0000191919.24185.46","article-title":"Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV.","volume":"19","author":"F Boutboul","year":"2005","journal-title":"AIDS"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.4049\/jimmunol.177.5.2784","article-title":"Age-related CD8<sup>+<\/sup> T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals.","volume":"177","author":"I Messaoudi","year":"2006","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00705-010-0626-z","article-title":"Distributional characteristics of CD25 and CD127 on CD4<sup>+<\/sup> T cell subsets in chronic HCV infection.","volume":"155","author":"T Shen","year":"2010","journal-title":"Arch Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.virol.2006.06.017","article-title":"HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.","volume":"353","author":"EJ Wherry","year":"2006","journal-title":"Virology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.","volume":"401","author":"F Sallusto","year":"1999","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.4049\/jimmunol.0803801","article-title":"Association of HIV-specific and total CD8<sup>+<\/sup> T memory phenotypes in subtype C HIV-1 infection with viral set point.","volume":"182","author":"WA Burgers","year":"2009","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.4049\/jimmunol.0903771","article-title":"A steady state of CD4<sup>+<\/sup> T cell memory maturation and activation is established during primary subtype C HIV-1 infection.","volume":"184","author":"P Maenetje","year":"2010","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/cyto.a.20643","article-title":"Phenotype and function of human T lymphocyte subsets: consensus and issues.","volume":"73","author":"V Appay","year":"2008","journal-title":"Cytometry A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<2037::AID-IMMU2037>3.0.CO;2-V","article-title":"Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells.","volume":"29","author":"F Sallusto","year":"1999","journal-title":"Eur J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nri1052","article-title":"Cytokine control of memory T-cell development and survival.","volume":"3","author":"KS Schluns","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells.","volume":"29","author":"CD Surh","year":"2008","journal-title":"Immunity"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.0105-2896.2006.00393.x","article-title":"Development, trafficking, and function of memory T-cell subsets.","volume":"211","author":"L Lefrancois","year":"2006","journal-title":"Immunol Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1084\/jem.20030725","article-title":"IL-7 promotes the transition of CD4 effectors to persistent memory cells.","volume":"198","author":"J Li","year":"2003","journal-title":"J Exp Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"953","DOI":"10.4269\/ajtmh.1982.31.953","article-title":"Endemic filariasis on a Pacific Island. II. Immunologic aspects: immunoglobulin, complement, and specific antifilarial IgG, IgM, and IgE antibodies.","volume":"31","author":"EA Ottesen","year":"1982","journal-title":"Am J Trop Med Hyg"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/infdis\/174.3.598","article-title":"Evidence for protective immunity to bancroftian filariasis in the Cook Islands.","volume":"174","author":"C Steel","year":"1996","journal-title":"J Infect Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1086\/321004","article-title":"Evolution of immunologic responsiveness of persons living in an area of endemic bancroftian filariasis: a 17-year follow-up.","volume":"184","author":"C Steel","year":"2001","journal-title":"J Infect Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4269\/ajtmh.1982.31.942","article-title":"Endemic filariasis on a Pacific island. I. Clinical, epidemiologic, and parasitologic aspects.","volume":"31","author":"PF Weller","year":"1982","journal-title":"Am J Trop Med Hyg"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/1097-0320(20011101)45:3<194::AID-CYTO1163>3.0.CO;2-C","article-title":"Spectral compensation for flow cytometry: visualization artifacts, limitations, and caveats.","volume":"45","author":"M Roederer","year":"2001","journal-title":"Cytometry"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e6690","DOI":"10.1371\/journal.pone.0006690","article-title":"Development of a quantitative bead capture assay for soluble IL-7 receptor alpha in human plasma.","volume":"4","author":"S Faucher","year":"2009","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1074-7613(01)00236-9","article-title":"Constitutive CD27\/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.","volume":"15","author":"R Arens","year":"2001","journal-title":"Immunity"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.4049\/jimmunol.0900852","article-title":"Chronic human infection with Trypanosoma cruzi drives CD4<sup>+<\/sup> T cells to immune senescence.","volume":"183","author":"MC Albareda","year":"2009","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.4049\/jimmunol.1000483","article-title":"The early generation of a heterogeneous CD4<sup>+<\/sup> T cell response to Leishmania major.","volume":"185","author":"SL Colpitts","year":"2010","journal-title":"J Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","article-title":"Helminth parasites\u2013masters of regulation.","volume":"201","author":"RM Maizels","year":"2004","journal-title":"Immunol Rev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1172\/JCI112982","article-title":"Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.","volume":"79","author":"TB Nutman","year":"1987","journal-title":"J Clin Invest"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.intimp.2008.03.016","article-title":"Immunoregulatory mechanisms and CD4\u2212CD8\u2212 (double negative) T cell subpopulations in human cutaneous leishmaniasis: a balancing act between protection and pathology.","volume":"8","author":"KJ Gollob","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0105-2896.2006.00382.x","article-title":"Signals required for programming effector and memory development by CD8<sup>+<\/sup> T cells.","volume":"211","author":"MF Mescher","year":"2006","journal-title":"Immunol Rev"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0531-5565(03)00134-7","article-title":"Age-associated accumulation of CMV-specific CD8<sup>+<\/sup> T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1).","volume":"38","author":"Q Ouyang","year":"2003","journal-title":"Exp Gerontol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI38482","article-title":"Anti-TNF immunotherapy reduces CD8<sup>+<\/sup> T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans.","volume":"119","author":"H Bruns","year":"2009","journal-title":"J Clin Invest"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1196\/annals.1354.009","article-title":"Human immunosenescence: does it have an infectious component?","volume":"1067","author":"G Pawelec","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20040876","article-title":"Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo.","volume":"201","author":"C Bouneaud","year":"2005","journal-title":"J Exp Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.coi.2005.04.010","article-title":"Understanding the generation and function of memory T cell subsets.","volume":"17","author":"A Lanzavecchia","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance.","volume":"22","author":"F Sallusto","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.4049\/jimmunol.174.10.5926","article-title":"Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help.","volume":"174","author":"MJ Fuller","year":"2005","journal-title":"J Immunol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/eji.200425828","article-title":"Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation.","volume":"35","author":"KS Lang","year":"2005","journal-title":"Eur J Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"13759","DOI":"10.1073\/pnas.212214999","article-title":"IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.","volume":"99","author":"HH Xue","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.4049\/jimmunol.180.4.2107","article-title":"Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction.","volume":"180","author":"CD Hammerbeck","year":"2008","journal-title":"J Immunol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1084\/jem.20011267","article-title":"Aging leads to disturbed homeostasis of memory phenotype CD8(<sup>+<\/sup>) cells.","volume":"195","author":"X Zhang","year":"2002","journal-title":"J Exp Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.4049\/jimmunol.180.8.5309","article-title":"Formation of IL-7Ralpha high and IL-7Ralpha low CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1.","volume":"180","author":"A Chandele","year":"2008","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0019197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:15:53Z","timestamp":1588990553000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0019197"}},"subtitle":[],"editor":[{"given":"Clotilde K. S.","family":"Carlow","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,29]]},"references-count":75,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0019197","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,29]]}}}