{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:42:17Z","timestamp":1792795337262,"version":"4.5.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0019390","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T21:29:56Z","timestamp":1304112596000},"page":"e19390","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":147,"title":["Tyrosine 23 Phosphorylation-Dependent Cell-Surface Localization of Annexin A2 Is Required for Invasion and Metastases of Pancreatic Cancer"],"prefix":"10.1371","volume":"6","author":[{"given":"Lei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Foley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Leubner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Olino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barish H.","family":"Edil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Mizuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dung T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Illei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Van Eyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Laheru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Jaffee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.critrevonc.2008.01.009","article-title":"Pancreatic cancer: progress in cancer therapy.","volume":"67","author":"C Pierantoni","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/annonc\/10.suppl_4.S4","article-title":"Progress in cancer genetics: lessons from pancreatic cancer.","volume":"10","author":"M Goggins","year":"1999","journal-title":"Ann Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10555-008-9134-y","article-title":"Pancreatic cancer: from molecular pathogenesis to targeted therapy.","volume":"27","author":"A Strimpakos","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"ref4","article-title":"A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine in Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation.","author":"E Lutz","year":"2010","journal-title":"Annals of Surgery [Epub ahead of print]"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1200\/JCO.2001.19.1.145","article-title":"Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation.","volume":"19","author":"EM Jaffee","year":"2001","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1158\/1078-0432.CCR-07-0371","article-title":"Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation.","volume":"14","author":"D Laheru","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1084\/jem.20031435","article-title":"Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients.","volume":"200","author":"AM Thomas","year":"2004","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejca.2007.08.028","article-title":"Mesothelin targeted cancer immunotherapy.","volume":"44","author":"R Hassan","year":"2008","journal-title":"Eur J Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/path.1935","article-title":"Tenascin C and annexin II expression in the process of pancreatic carcinogenesis.","volume":"208","author":"I Esposito","year":"2006","journal-title":"J Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.2174\/138161207782794167","article-title":"The role of annexin II in angiogenesis and tumor progression: a potential therapeutic target.","volume":"13","author":"MC Sharma","year":"2007","journal-title":"Curr Pharm Des"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2741\/1529","article-title":"S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors.","volume":"10","author":"M Kwon","year":"2005","journal-title":"Front Biosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"d341","DOI":"10.2741\/kim","article-title":"Annexin II: a plasminogen-plasminogen activator co-receptor.","volume":"7","author":"J Kim","year":"2002","journal-title":"Front Biosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1242\/jcs.01245","article-title":"Annexins\u2013unique membrane binding proteins with diverse functions.","volume":"117","author":"U Rescher","year":"2004","journal-title":"J Cell Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1128\/MCB.01247-07","article-title":"Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation.","volume":"28","author":"M de Graauw","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1242\/jcs.028415","article-title":"Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion.","volume":"121","author":"U Rescher","year":"2008","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"43411","DOI":"10.1074\/jbc.M408078200","article-title":"An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface.","volume":"279","author":"AB Deora","year":"2004","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0960-9822(01)00321-9","article-title":"Annexin 2 has an essential role in actin-based macropinocytic rocketing.","volume":"11","author":"CJ Merrifield","year":"2001","journal-title":"Curr Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.devcel.2008.05.009","article-title":"Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.","volume":"14","author":"J Yang","year":"2008","journal-title":"Dev Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ydbio.2003.08.026","article-title":"Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart.","volume":"265","author":"S Krishnan","year":"2004","journal-title":"Dev Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1158\/0008-5472.CAN-07-5123","article-title":"Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.","volume":"68","author":"S Zhao","year":"2008","journal-title":"Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/carcin\/bgm249","article-title":"Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression.","volume":"29","author":"KJ Gordon","year":"2008","journal-title":"Carcinogenesis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1074\/jbc.M806499200","article-title":"Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation.","volume":"284","author":"E Morel","year":"2009","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0167-4838(92)90039-G","article-title":"S-100 protein binds to annexin II and p11, the heavy and light chains of calpactin I.","volume":"1160","author":"R Bianchi","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1074\/jbc.M210545200","article-title":"Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor.","volume":"278","author":"WQ Zhao","year":"2003","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1158\/0008-5472.CAN-06-3281","article-title":"Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.","volume":"67","author":"G Feldmann","year":"2007","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1245\/s10434-008-0061-5","article-title":"Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy.","volume":"15","author":"S Takano","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/sj.bjc.6605289","article-title":"S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.","volume":"101","author":"T Nedjadi","year":"2009","journal-title":"Br J Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"12595","DOI":"10.1074\/jbc.M800189200","article-title":"Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells.","volume":"283","author":"C Hastie","year":"2008","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1586\/era.09.109","article-title":"Novel agents for the treatment of adenocarcinoma of the pancreas.","volume":"9","author":"RP Mackenzie","year":"2009","journal-title":"Expert Rev Anticancer Ther"},{"key":"ref30","first-page":"2281","article-title":"Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.","volume":"40","author":"IR Hart","year":"1980","journal-title":"Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.","volume":"321","author":"S Jones","year":"2008","journal-title":"Science"},{"key":"ref32","first-page":"194","article-title":"Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.","volume":"4","author":"EM Jaffee","year":"1998","journal-title":"Cancer J Sci Am"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/sj.onc.1206386","article-title":"A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis.","volume":"22","author":"B Wang","year":"2003","journal-title":"Oncogene"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10875-008-9188-1","article-title":"Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome.","volume":"28","author":"V Salle","year":"2008","journal-title":"J Clin Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1089\/104303403322124800","article-title":"Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells.","volume":"14","author":"X Zhou","year":"2003","journal-title":"Hum Gene Ther"},{"key":"ref36","first-page":"3620","article-title":"A modified invasion-3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay for quantitating tumor cell invasion.","volume":"54","author":"H Imamura","year":"1994","journal-title":"Cancer Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1128\/MCB.17.10.6049","article-title":"HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis.","volume":"17","author":"Y Chen","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0092-8674(82)90159-3","article-title":"Nuclear location of the putative transforming protein of avian myelocytomatosis virus.","volume":"29","author":"HD Abrams","year":"1982","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1245\/ASO.2003.10.006","article-title":"Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases.","volume":"10","author":"A Jain","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1158\/0008-5472.CAN-05-2307","article-title":"Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes.","volume":"66","author":"K Yoshimura","year":"2006","journal-title":"Cancer Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0019390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:02:50Z","timestamp":1589025770000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0019390"}},"subtitle":[],"editor":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,29]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0019390","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,29]]}}}