{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:44:14Z","timestamp":1790891054452,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0019559","type":"journal-article","created":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T20:48:11Z","timestamp":1305146891000},"page":"e19559","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["MCP-1 Upregulates Amylin Expression in Murine Pancreatic \u03b2 Cells through ERK\/JNK-AP1 and NF-\u03baB Related Signaling Pathways Independent of CCR2"],"prefix":"10.1371","volume":"6","author":[{"given":"Kun","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0531-5565(03)00004-4","article-title":"Islet amyloid polypeptide and type 2 diabetes.","volume":"38","author":"L Marzban","year":"2003","journal-title":"Exp Gerontol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.","volume":"84","author":"GJ Cooper","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","article-title":"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.","volume":"84","author":"P Westermark","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.2337\/db05-1672","article-title":"Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.","volume":"55","author":"AV Matveyenko","year":"2006","journal-title":"Diabetes"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15330","DOI":"10.1074\/jbc.M908045199","article-title":"Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.","volume":"275","author":"WM Macfarlane","year":"2000","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E938","DOI":"10.1152\/ajpendo.2001.281.5.E938","article-title":"Glucose and forskolin regulate IAPP gene expression through different signal transduction pathways.","volume":"281","author":"WQ Ding","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E99","DOI":"10.1152\/ajpendo.00242.2009","article-title":"Fatty acids induce amylin expression and secretion by pancreatic beta-cells.","volume":"298","author":"D Qi","year":"2010","journal-title":"Am J Physiol Endocrinol Metab 2010;"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00500385","article-title":"Plasma islet amyloid polypeptide (Amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients.","volume":"34","author":"T Sanke","year":"1991","journal-title":"Diabetologia"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00400933","article-title":"Islet amyloid polypeptide plasma concentrations in individuals at increased risk of developing type 2 (non-insulin-dependent) diabetes mellitus.","volume":"35","author":"J Eriksson","year":"1992","journal-title":"Diabetologia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0168-8227(92)90074-2","article-title":"Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus.","volume":"15","author":"S Enoki","year":"1992","journal-title":"Diabetes Res Clin Pract"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1038\/oby.2007.239","article-title":"Amylin and its relation to insulin and lipids in obese children before and after weight loss.","volume":"15","author":"T Reinehr","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"I101","DOI":"10.1161\/01.HYP.19.1_Suppl.I101","article-title":"Hyperamylinemia, hyperinsulinemia, and insulin resistance in genetically obese LA\/N-cp rats.","volume":"19","author":"HJ Huang","year":"1992","journal-title":"Hypertension"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11892-005-0071-7","article-title":"The evolving role of inflammation in obesity and the metabolic syndrome.","volume":"5","author":"YH Lee","year":"2005","journal-title":"Curr Diab Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/sj.ijo.0802839","article-title":"Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects.","volume":"29","author":"T Christiansen","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/sj.ijo.0803259","article-title":"Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters.","volume":"30","author":"CS Kim","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00125-006-0190-y","article-title":"Chemokines as risk factors for type 2 diabetes: results from the MONICA\/KORA Augsburg study, 1984-2002.","volume":"49","author":"C Herder","year":"2006","journal-title":"Diabetologia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1210\/endo.130.1.1727716","article-title":"Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.","volume":"130","author":"CH Lang","year":"1992","journal-title":"Endocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1210\/endo.139.12.6336","article-title":"An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha.","volume":"139","author":"AT Cheung","year":"1998","journal-title":"Endocrinology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MOL.0b013e3281338546","article-title":"Monocyte chemotactic protein-1 and its role in insulin resistance.","volume":"18","author":"H Sell","year":"2007","journal-title":"Curr Opin Lipidol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1017\/S0029665109990218","article-title":"Chemotactic cytokines, obesity and type 2 diabetes: in vivo and in vitro evidence for a possible causal correlation?","volume":"68","author":"H Sell","year":"2009","journal-title":"Proc Nutr Soc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00125-010-1972-9","article-title":"TNF-\u03b1 acutely upregulates amylin expression in murine pancreatic beta cells.","volume":"54","author":"K Cai","year":"2011","journal-title":"Diabetologia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","article-title":"Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells.","volume":"39","author":"SE Kahn","year":"1990","journal-title":"Diabetes"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1210\/me.2004-0407","article-title":"Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells.","volume":"19","author":"L Marzban","year":"2005","journal-title":"Mol Endocrinol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0008-6363(02)00600-4","article-title":"MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells.","volume":"56","author":"M Werle","year":"2002","journal-title":"Cardiovasc Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1182\/blood.V97.2.359","article-title":"Signal transduction involved in MCP-1-mediated monocytic transendothelial migration.","volume":"97","author":"B Cambien","year":"2001","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/10799900252981990","article-title":"Monocyte chemoattractant protein-1-induced activation of p42\/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation.","volume":"22","author":"A Sodhi","year":"2002","journal-title":"J Interferon Cytokine Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1097\/01.ASN.0000015609.31253.7F","article-title":"MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1.","volume":"13","author":"C Viedt","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.ATV.0000019009.73586.7F","article-title":"Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1.","volume":"22","author":"C Viedt","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3835(02)00170-2","article-title":"New and known symmetrical curcumin derivatives inhibit the formation of Fos-Jun-DNA complex.","volume":"184","author":"ER Hahm","year":"2002","journal-title":"Cancer Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"The targets of curcumin.","volume":"12","author":"H Zhou","year":"2011","journal-title":"Curr Drug Targets"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1471-4914(02)00009-6","article-title":"Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4.","volume":"9","author":"MR Young","year":"2003","journal-title":"Trends Mol Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1053\/gast.2000.19458","article-title":"Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta.","volume":"119","author":"CK Weber","year":"2000","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ni1465","article-title":"The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.","volume":"8","author":"T Zhao","year":"2007","journal-title":"Nat Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/diabetes.52.11.2759","article-title":"Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes.","volume":"52","author":"HL Zhao","year":"2003","journal-title":"Diabetes"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF00403322","article-title":"Islet amyloid polypeptide in diabetic and non-diabetic Pima Indians.","volume":"33","author":"A Clark","year":"1990","journal-title":"Diabetologia"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJM200008103430607","article-title":"Islet amyloid and type 2 diabetes mellitus.","volume":"343","author":"JW H\u00f6ppener","year":"2000","journal-title":"N Engl J Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1210\/jc.2004-0405","article-title":"Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes.","volume":"89","author":"RL Hull","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0006-291X(89)92529-1","article-title":"Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets.","volume":"160","author":"H Ohsawa","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"E1656","DOI":"10.1152\/ajpendo.00318.2007","article-title":"Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.","volume":"293","author":"CJ Huang","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.2337\/db07-0178","article-title":"Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.","volume":"56","author":"S Casas","year":"2007","journal-title":"Diabetes"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/335632a0","article-title":"Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.","volume":"335","author":"B Leighton","year":"1988","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF00401051","article-title":"Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs.","volume":"33","author":"R Sowa","year":"1990","journal-title":"Diabetologia"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1074\/jbc.271.4.1988","article-title":"Pore formation by the cytotoxic islet amyloid peptide amylin.","volume":"271","author":"TA Mirzabekov","year":"1996","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.1021\/bi020314u","article-title":"Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes.","volume":"41","author":"M Anguiano","year":"2002","journal-title":"Biochemistry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.2337\/diacare.26.10.2883","article-title":"Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality.","volume":"26","author":"L Piemonti","year":"2003","journal-title":"Diabetes Care"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/1479164109346364","article-title":"Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians.","volume":"6","author":"K Harsimran","year":"2009","journal-title":"Diab Vasc Dis Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1210\/en.2005-0969","article-title":"Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle.","volume":"147","author":"H Sell","year":"2006","journal-title":"Endocrinology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1073\/pnas.1133870100","article-title":"Monocyte chemoattractant protein 1 in obesity and insulin resistance.","volume":"100","author":"P Sartipy","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.","volume":"116","author":"H Kanda","year":"2006","journal-title":"J Clin Invest"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1074\/jbc.M601284200","article-title":"Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.","volume":"281","author":"N Kamei","year":"2006","journal-title":"J Biol Chem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1210\/en.2009-0926","article-title":"An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice.","volume":"151","author":"S Tateya","year":"2010","journal-title":"Endocrinology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1046\/j.1600-6143.2003.00215.x","article-title":"Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets.","volume":"3","author":"N Zhang","year":"2003","journal-title":"Am J Transplant"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1097-4547(19960815)45:4<382::AID-JNR7>3.0.CO;2-5","article-title":"Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor.","volume":"45","author":"M Heesen","year":"1996","journal-title":"J Neurosci Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"28568","DOI":"10.1074\/jbc.272.45.28568","article-title":"Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells.","volume":"272","author":"AD Schecter","year":"1997","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1189\/jlb.0903421","article-title":"MCP-1-dependent signaling in CCR2(-\/-) aortic smooth muscle cells.","volume":"75","author":"AD Schecter","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0168-8227(89)90008-9","article-title":"Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans.","volume":"7","author":"P Westermark","year":"1989","journal-title":"Diabetes Res Clin Pract"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","article-title":"Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.","volume":"48","author":"SE Kahn","year":"1999","journal-title":"Diabetes"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2337\/diab.38.11.1333","article-title":"Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?","volume":"38","author":"D Porte Jr","year":"1989","journal-title":"Diabetes"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00125-003-1304-4","article-title":"Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?","volume":"47","author":"A Clark","year":"2004","journal-title":"Diabetologia"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0925-4439(01)00078-3","article-title":"Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.","volume":"1537","author":"ET Jaikaran","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/ni.1614","article-title":"Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition.","volume":"9","author":"X Wang","year":"2008","journal-title":"Nat Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1210\/en.2004-1175","article-title":"Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.","volume":"146","author":"L Marzban","year":"2005","journal-title":"Endocrinology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2004.03.002","article-title":"Ovarian expression of chemokines and their receptors.","volume":"63","author":"C Zhou","year":"2004","journal-title":"J Reprod Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1210\/en.2007-0106","article-title":"Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells.","volume":"149","author":"O Wang","year":"2008","journal-title":"Endocrinology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0019559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T18:37:33Z","timestamp":1560191853000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0019559"}},"subtitle":[],"editor":[{"given":"Gian Paolo","family":"Fadini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,5,11]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0019559","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,11]]}}}