{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:29Z","timestamp":1787021849352,"version":"build-2736575974"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T00:00:00Z","timestamp":1305158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0019632","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:52:28Z","timestamp":1305219148000},"page":"e19632","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Unc-51\/ATG1 Controls Axonal and Dendritic Development via Kinesin-Mediated Vesicle Transport in the Drosophila Brain"],"prefix":"10.1371","volume":"6","author":[{"given":"Hiroaki","family":"Mochizuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Toda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Kurusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuo","family":"Furukubo-Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ceb.2004.06.002","article-title":"Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction.","volume":"16","author":"BW Guzik","year":"2004","journal-title":"Curr Opin Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tcb.2009.05.001","article-title":"Roles of endosomal trafficking in neurite outgrowth and guidance.","volume":"19","author":"S Sann","year":"2009","journal-title":"Trends Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.conb.2004.08.011","article-title":"Molecular motors in neuronal development, intracellular transport and diseases.","volume":"14","author":"N Hirokawa","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.neuro.31.060407.125536","article-title":"Establishment of axon-dendrite polarity in developing neurons.","volume":"32","author":"AP Barnes","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0896-6273(03)00629-9","article-title":"Neuronal polarity and trafficking.","volume":"40","author":"AC Horton","year":"2003","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ydbio.2008.12.013","article-title":"The specific targeting of guidance receptors within neurons: who directs the directors?","volume":"327","author":"J Allen","year":"2009","journal-title":"Dev Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2007.06.032","article-title":"Growing dendrites and axons differ in their reliance on the secretory pathway.","volume":"130","author":"B Ye","year":"2007","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2005.11.005","article-title":"Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis.","volume":"48","author":"AC Horton","year":"2005","journal-title":"Neuron"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/ncb1777","article-title":"Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.","volume":"10","author":"Y Zheng","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/ncb1776","article-title":"Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes.","volume":"10","author":"D Satoh","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0012-1606(85)90443-9","article-title":"Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes.","volume":"111","author":"EM Hedgecock","year":"1985","journal-title":"Dev Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1101\/gad.8.20.2389","article-title":"Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine\/threonine kinase.","volume":"8","author":"K Ogura","year":"1994","journal-title":"Genes Dev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0896-6273(00)81031-4","article-title":"A mouse serine\/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons.","volume":"24","author":"T Tomoda","year":"1999","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1101\/gad.1151204","article-title":"Role of Unc51.1 and its binding partners in CNS axon outgrowth.","volume":"18","author":"T Tomoda","year":"2004","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1523\/JNEUROSCI.3848-08.2009","article-title":"Unc-51 controls active zone density and protein composition by downregulating ERK signaling.","volume":"29","author":"YP Wairkar","year":"2009","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1101\/gad.1734608","article-title":"UNC-51\/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly.","volume":"22","author":"H Toda","year":"2008","journal-title":"Genes Dev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1073\/pnas.0701402104","article-title":"Unc-51-like kinase 1\/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.","volume":"104","author":"X Zhou","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0896-6273(92)90297-Q","article-title":"Genes necessary for directed axonal elongation or fasciculation in C. elegans.","volume":"8","author":"SL McIntire","year":"1992","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nn1835","article-title":"VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.","volume":"10","author":"N Levy-Strumpf","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1242\/dev.01457","article-title":"The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.","volume":"131","author":"T Lai","year":"2004","journal-title":"Development"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nn1834","article-title":"C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.","volume":"10","author":"N Watari-Goshima","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1091\/mbc.E04-07-0553","article-title":"The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.","volume":"16","author":"R Sakamoto","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1242\/dev.02503","article-title":"The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.","volume":"133","author":"K Ogura","year":"2006","journal-title":"Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7905","DOI":"10.1523\/JNEUROSCI.2135-05.2005","article-title":"Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae.","volume":"25","author":"K Honjo","year":"2005","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1523\/JNEUROSCI.1315-08.2009","article-title":"Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae.","volume":"29","author":"K Honjo","year":"2009","journal-title":"J Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrn1074","article-title":"Mushroom body memoir: from maps to models.","volume":"4","author":"M Heisenberg","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1073\/pnas.040564497","article-title":"Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and Dachshund genes.","volume":"97","author":"M Kurusu","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.129.2.409","article-title":"Embryonic and larval development of the Drosophila mushroom bodies: concentric layer subdivisions and the role of fasciclin II.","volume":"129","author":"M Kurusu","year":"2002","journal-title":"Development"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0896-6273(00)80349-9","article-title":"Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS.","volume":"19","author":"Y Iwai","year":"1997","journal-title":"Neuron"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004410050901","article-title":"GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system.","volume":"290","author":"K Ito","year":"1997","journal-title":"Cell Tissue Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0896-6273(00)81169-1","article-title":"Drosophila Futsch\/22C10 is a MAP1B-like protein required for dendritic and axonal development.","volume":"26","author":"T Hummel","year":"2000","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.","volume":"22","author":"T Lee","year":"1999","journal-title":"Neuron"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"R700","DOI":"10.1016\/j.cub.2009.06.026","article-title":"Olfactory information processing in Drosophila.","volume":"19","author":"NY Masse","year":"2009","journal-title":"Curr Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1097-4695(199705)32:5<443::AID-NEU1>3.0.CO;2-5","article-title":"Neuroblast ablation in Drosophila P[GAL4] lines reveals origins of olfactory interneurons.","volume":"32","author":"RF Stocker","year":"1997","journal-title":"J Neurobiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/(SICI)1096-9861(19990322)405:4<543::AID-CNE7>3.0.CO;2-A","article-title":"Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster.","volume":"405","author":"PP Laissue","year":"1999","journal-title":"J Comp Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1091\/mbc.E05-06-0526","article-title":"Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons.","volume":"17","author":"AD Pilling","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2004.07.009","article-title":"Role and regulation of starvation-induced autophagy in the Drosophila fat body.","volume":"7","author":"RC Scott","year":"2004","journal-title":"Dev Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cub.2006.10.053","article-title":"Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death.","volume":"17","author":"RC Scott","year":"2007","journal-title":"Curr Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.devcel.2004.07.005","article-title":"Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.","volume":"7","author":"TE Rusten","year":"2004","journal-title":"Dev Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1091\/mbc.E08-12-1250","article-title":"An Atg1\/Atg13 complex with multiple roles in TOR-mediated autophagy regulation.","volume":"20","author":"YY Chang","year":"2009","journal-title":"Mol Biol Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4161\/auto.5141","article-title":"Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation.","volume":"4","author":"GC Chen","year":"2008","journal-title":"Autophagy"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/sj.embor.7400917","article-title":"ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase.","volume":"8","author":"SB Lee","year":"2007","journal-title":"EMBO Rep"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.200907109","article-title":"Autophagy promotes synapse development in Drosophila.","volume":"187","author":"W Shen","year":"2009","journal-title":"J Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1083\/jcb.141.2.443","article-title":"Kinesin light chains are essential for axonal transport in Drosophila.","volume":"141","author":"JG Gindhart Jr","year":"1998","journal-title":"J Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1534\/genetics.104.026427","article-title":"The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes.","volume":"167","author":"HJ Bellen","year":"2004","journal-title":"Genetics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mcn.2008.01.015","article-title":"Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.","volume":"38","author":"M Kurusu","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuron.2004.06.033","article-title":"Transmembrane\/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis.","volume":"43","author":"J Wang","year":"2004","journal-title":"Neuron"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1523\/JNEUROSCI.1517-07.2007","article-title":"Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization.","volume":"27","author":"L Shi","year":"2007","journal-title":"J Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e3504","DOI":"10.1371\/journal.pone.0003504","article-title":"Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam.","volume":"3","author":"JS Yang","year":"2008","journal-title":"PLoS ONE"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/dev.124.2.461","article-title":"Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle.","volume":"124","author":"IE Clark","year":"1997","journal-title":"Development"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/dev.00319","article-title":"A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis.","volume":"130","author":"JE Reuter","year":"2003","journal-title":"Development"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1523\/JNEUROSCI.2005-05.2005","article-title":"Calcium\/calmodulin-dependent protein kinase II alters structural plasticity and cytoskeletal dynamics in Drosophila.","volume":"25","author":"R Andersen","year":"2005","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1101\/gad.11.14.1801","article-title":"The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine\/threonine kinase UNC-51.","volume":"11","author":"K Ogura","year":"1997","journal-title":"Genes Dev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.str.2008.10.014","article-title":"Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain.","volume":"17","author":"R Recacha","year":"2009","journal-title":"Structure"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0896-6273(00)81006-5","article-title":"vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity.","volume":"20","author":"FW Wolf","year":"1998","journal-title":"Neuron"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(00)00218-7","article-title":"Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.","volume":"85","author":"N Okazaki","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1083\/jcb.200705154","article-title":"In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2.","volume":"179","author":"H Kohsaka","year":"2007","journal-title":"J Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1242\/jcs.02502","article-title":"Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.","volume":"118","author":"S Pulipparacharuvil","year":"2005","journal-title":"J Cell Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1126\/science.274.5295.2104","article-title":"Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies.","volume":"274","author":"JB Connolly","year":"1996","journal-title":"Science"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.mod.2003.08.007","article-title":"Conserved cis-regulatory modules mediate complex neural expression patterns of the eyeless gene in the Drosophila brain.","volume":"120","author":"Y Adachi","year":"2003","journal-title":"Mech Dev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(95)90063-2","article-title":"Subdivision of the Drosophila mushroom bodies by enhancer-trap expression patterns.","volume":"15","author":"MY Yang","year":"1995","journal-title":"Neuron"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1101\/gad.8.15.1787","article-title":"Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.","volume":"8","author":"L Luo","year":"1994","journal-title":"Genes Dev"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0896-6273(94)90045-0","article-title":"Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation.","volume":"13","author":"DM Lin","year":"1994","journal-title":"Neuron"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/gene.10144","article-title":"Living synaptic vesicle marker: synaptotagmin-GFP.","volume":"34","author":"YQ Zhang","year":"2002","journal-title":"Genesis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1534\/genetics.106.066761","article-title":"Thirty-one flavors of Drosophila rab proteins.","volume":"176","author":"J Zhang","year":"2007","journal-title":"Genetics"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature00846","article-title":"The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.","volume":"418","author":"JM Mackler","year":"2002","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0019632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:29:09Z","timestamp":1637627349000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0019632"}},"subtitle":[],"editor":[{"given":"Brian D.","family":"McCabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,5,12]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0019632","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,12]]}}}