{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:09:00Z","timestamp":1791220140557,"version":"4.1.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T00:00:00Z","timestamp":1306454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020360","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T20:57:03Z","timestamp":1306529823000},"page":"e20360","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":226,"title":["Pharmacogenetic Modulation of Orexin Neurons Alters Sleep\/Wakefulness States in Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Koh","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Mieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Tsujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.96.19.10911","article-title":"Orexin A activates locus coeruleus cell firing and increases arousal in the rat.","volume":"96","author":"JJ Hagan","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrn2092","article-title":"The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.","volume":"8","author":"T Sakurai","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1523\/JNEUROSCI.1887-05.2005","article-title":"Discharge of identified orexin\/hypocretin neurons across the sleep-waking cycle.","volume":"25","author":"MG Lee","year":"2005","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.neuroscience.2008.02.058","article-title":"Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse.","volume":"153","author":"K Takahashi","year":"2008","journal-title":"Neuroscience"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2005.04.035","article-title":"Behavioral correlates of activity in identified hypocretin\/orexin neurons.","volume":"46","author":"BY Mileykovskiy","year":"2005","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1523\/JNEUROSCI.1205-09.2009","article-title":"Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions.","volume":"29","author":"ME Carter","year":"2009","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature06310","article-title":"Neural substrates of awakening probed with optogenetic control of hypocretin neurons.","volume":"450","author":"AR Adamantidis","year":"2007","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1073\/pnas.0700293104","article-title":"Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.","volume":"104","author":"BN Armbruster","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2009.06.014","article-title":"Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.","volume":"63","author":"GM Alexander","year":"2009","journal-title":"Neuron"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nn.2703","article-title":"Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization.","volume":"14","author":"SM Ferguson","year":"2011","journal-title":"Nat Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1523\/JNEUROSCI.1193-05.2005","article-title":"Cholecystokinin activates orexin\/hypocretin neurons through the cholecystokinin A receptor.","volume":"25","author":"N Tsujino","year":"2005","journal-title":"J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1073\/pnas.0811126106","article-title":"Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep\/wakefulness architecture.","volume":"106","author":"T Matsuki","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.1168878","article-title":"Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning.","volume":"324","author":"HC Tsai","year":"2009","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.","author":"MJ Krashes","year":"2011"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1523\/JNEUROSCI.21-05-01656.2001","article-title":"Fos expression in orexin neurons varies with behavioral state.","volume":"21","author":"IV Estabrooke","year":"2001","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.0953-816x.2001.01725.x","article-title":"Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.","volume":"14","author":"Y Yoshida","year":"2001","journal-title":"Eur J Neurosci"},{"key":"ref17","first-page":"195","article-title":"Neurons specifiques de l'eveil dans l'hypothalamus posterieur du chat.","volume":"III 298","author":"G Vanni-Mercier","year":"1984","journal-title":"CR Acad Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1523\/JNEUROSCI.22-11-04568.2002","article-title":"Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep.","volume":"22","author":"J Lu","year":"2002","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/187152706777452218","article-title":"Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis.","volume":"5","author":"T Sakurai","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/cne.20859","article-title":"Afferents to the orexin neurons of the rat brain.","volume":"494","author":"K Yoshida","year":"2006","journal-title":"J Comp Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0896-6273(03)00331-3","article-title":"Hypothalamic orexin neurons regulate arousal according to energy balance in mice.","volume":"38","author":"A Yamanaka","year":"2003","journal-title":"Neuron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1523\/JNEUROSCI.4925-04.2005","article-title":"Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ.","volume":"25","author":"D Burdakov","year":"2005","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/104303401450988","article-title":"Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.","volume":"12","author":"A Auricchio","year":"2001","journal-title":"Hum Gene Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1073\/pnas.0802866105","article-title":"Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.","volume":"105","author":"L Zhong","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain.","volume":"827","author":"T Nambu","year":"1999","journal-title":"Brain Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T03:19:12Z","timestamp":1686107952000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020360"}},"subtitle":[],"editor":[{"given":"Olivier Jacques","family":"Manzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,5,27]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020360","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,27]]}}}