{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:30:53Z","timestamp":1770413453830,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020634","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T21:24:17Z","timestamp":1306877057000},"page":"e20634","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Heme Oxygenase-1 Deletion Affects Stress Erythropoiesis"],"prefix":"10.1371","volume":"6","author":[{"given":"Yu-An","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Kusy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Luong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher H.","family":"Contag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0b013e3280de2bf1","article-title":"Molecular insights into stress erythropoiesis.","volume":"14","author":"M Socolovsky","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.61.2.748","article-title":"The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.","volume":"61","author":"R Tenhunen","year":"1968","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.192.7.1015","article-title":"Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.","volume":"192","author":"S Brouard","year":"2000","journal-title":"J Exp Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/89068","article-title":"Heme oxygenase-1 protects against vascular constriction and proliferation.","volume":"7","author":"HJ Duckers","year":"2001","journal-title":"Nat Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","article-title":"Heme oxygenase 1 is required for mammalian iron reutilization.","volume":"94","author":"KD Poss","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1096\/fj.04-2217fje","article-title":"Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells.","volume":"19","author":"J McDaid","year":"2005","journal-title":"FASEB J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.4049\/jimmunol.179.11.7840","article-title":"Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276.","volume":"179","author":"MP Seldon","year":"2007","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.4049\/jimmunol.172.6.3553","article-title":"Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation.","volume":"172","author":"MP Soares","year":"2004","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/pr.107.07104","article-title":"Pharmacological and clinical aspects of heme oxygenase.","volume":"60","author":"NG Abraham","year":"2008","journal-title":"Pharmacol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","article-title":"Reduced stress defense in heme oxygenase 1-deficient cells.","volume":"94","author":"KD Poss","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.2741\/2439","article-title":"Heme oxygenase-1 in organ transplantation.","volume":"12","author":"MP Soares","year":"2007","journal-title":"Front Biosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/hupa.2002.30217","article-title":"Heme oxygenase-1 deficiency: the first autopsy case.","volume":"33","author":"A Kawashima","year":"2002","journal-title":"Hum Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1172\/JCI4165","article-title":"Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency.","volume":"103","author":"A Yachie","year":"1999","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1182\/blood-2007-12-127621","article-title":"Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.","volume":"112","author":"YA Cao","year":"2008","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1182\/blood-2005-11-4458","article-title":"Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.","volume":"108","author":"Y Liu","year":"2006","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1182\/blood-2006-03-006759","article-title":"Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation.","volume":"108","author":"G Lee","year":"2006","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/stem.5530050103","article-title":"Effects of recombinant human tumor necrosis factor (rhTNF) on normal human and mouse hemopoietic progenitor cells.","volume":"5","author":"K Akahane","year":"1987","journal-title":"Int J Cell Cloning"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1096\/fasebj.3.5.2784116","article-title":"Cachectin\/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo.","volume":"3","author":"LL Moldawer","year":"1989","journal-title":"FASEB J"},{"key":"ref19","first-page":"311","article-title":"Tumor necrosis factor exerts dose-dependent effects on erythropoiesis and myelopoiesis in vivo.","volume":"18","author":"TR Ulich","year":"1990","journal-title":"Exp Hematol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4049\/jimmunol.177.4.2592","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes.","volume":"177","author":"Y Drechsler","year":"2006","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.","volume":"6","author":"LE Otterbein","year":"2000","journal-title":"Nat Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1432-0436.1982.tb01201.x","article-title":"Ultrastructural aspects of erythropoietic differentiation in long-term bone marrow culture.","volume":"21","author":"TD Allen","year":"1982","journal-title":"Differentiation"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1084\/jem.181.1.411","article-title":"Very late activation antigen 4-vascular cell adhesion molecule 1 interaction is involved in the formation of erythroblastic islands.","volume":"181","author":"Y Sadahira","year":"1995","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1182\/blood.V79.7.1686.1686","article-title":"Integrin expression profiles during erythroid differentiation.","volume":"79","author":"T Papayannopoulou","year":"1992","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1182\/blood.V88.1.75.75","article-title":"Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen.","volume":"88","author":"VC Broudy","year":"1996","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ajh.2830010410","article-title":"Erthropoietic precursors in mice with phenylhydrazine-induced anemia.","volume":"1","author":"H Hara","year":"1976","journal-title":"Am J Hematol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1182\/blood-2004-02-0703","article-title":"BMP4 and Madh5 regulate the erythroid response to acute anemia.","volume":"105","author":"LE Lenox","year":"2005","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1247\/csf.24.171","article-title":"Cellular and molecular regulation of an erythropoietic inductive microenvironment (EIM).","volume":"24","author":"M Obinata","year":"1999","journal-title":"Cell Struct Funct"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0268-960X(98)90022-4","article-title":"Developmental biology of erythropoiesis.","volume":"12","author":"J Palis","year":"1998","journal-title":"Blood Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.imbio.2010.05.020","article-title":"Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release.","volume":"215","author":"E Sierra-Filardi","year":"2010","journal-title":"Immunobiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1083\/jcb.200702080","article-title":"Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development.","volume":"177","author":"S Eshghi","year":"2007","journal-title":"J Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1182\/blood.V87.6.2513.bloodjournal8762513","article-title":"A critical role of VLA-4 in erythropoiesis in vivo.","volume":"87","author":"K Hamamura","year":"1996","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1172\/JCI115002","article-title":"Coexpression of two fibronectin receptors, VLA-4 and VLA-5, by immature human erythroblastic precursor cells.","volume":"87","author":"M Rosemblatt","year":"1991","journal-title":"J Clin Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1182\/blood.V69.6.1587.1587","article-title":"Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin.","volume":"69","author":"S Tsai","year":"1987","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1182\/blood.V75.4.865.bloodjournal754865","article-title":"Loss of attachment to fibronectin with terminal human erythroid differentiation.","volume":"75","author":"MH Vuillet-Gaugler","year":"1990","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1074-7613(00)80131-4","article-title":"Alpha4 integrins regulate the proliferation\/differentiation balance of multilineage hematopoietic progenitors in vivo.","volume":"11","author":"AG Arroyo","year":"1999","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1182\/blood-2007-08-107581","article-title":"Enucleation of primitive erythroid cells generates a transient population of \u201cpyrenocytes\u201d in the mammalian fetus.","volume":"111","author":"KE McGrath","year":"2008","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1600-0609.2006.00788.x","article-title":"Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties.","volume":"78","author":"S Gambero","year":"2007","journal-title":"Eur J Haematol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.freeradbiomed.2004.07.008","article-title":"The role of heme oxygenase-1 promoter polymorphisms in human disease.","volume":"37","author":"M Exner","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0145-2126(01)00193-X","article-title":"In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndrome.","volume":"26","author":"E Flores-Figueroa","year":"2002","journal-title":"Leuk Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/sj.leu.2403551","article-title":"CD34+ marrow progenitors from MDS patients with high levels of intramedullary apoptosis have reduced expression of alpha4beta1 and alpha5beta1 integrins.","volume":"19","author":"M Delforge","year":"2005","journal-title":"Leukemia"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T07:26:55Z","timestamp":1712474815000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020634"}},"subtitle":[],"editor":[{"given":"Steven R.","family":"Ellis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,5,31]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020634","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,31]]}}}