{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:37:57Z","timestamp":1790858277717,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,2]],"date-time":"2011-06-02T00:00:00Z","timestamp":1306972800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020792","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T11:49:14Z","timestamp":1307101754000},"page":"e20792","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Cytokine Effects on Gap Junction Communication and Connexin Expression in Human Bladder Smooth Muscle Cells and Suburothelial Myofibroblasts"],"prefix":"10.1371","volume":"6","author":[{"given":"Marco","family":"Heinrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Oberbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Schlichting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Uwe","family":"Stolzenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1464-410X.2002.02834.x","article-title":"Gap junctions and connexin expression in human suburothelial interstitial cells.","volume":"90","author":"GP Sui","year":"2002","journal-title":"BJU Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"F1065","DOI":"10.1152\/ajprenal.00229.2006","article-title":"Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists.","volume":"292","author":"A Kanai","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1464-410X.2005.05703.x","article-title":"Alterations in connexin expression in the bladder of patients with urge symptoms.","volume":"96","author":"J Neuhaus","year":"2005","journal-title":"BJU Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.eururo.2008.03.090","article-title":"TGF-beta1 Inhibits Cx43 Expression and Formation of Functional Syncytia in Cultured Smooth Muscle Cells from Human Detrusor.","volume":"55","author":"J Neuhaus","year":"2009","journal-title":"Eur Urol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.eururo.2004.08.020","article-title":"Increased expression of connexin 43 in the overactive neurogenic detrusor.","volume":"46","author":"A Haferkamp","year":"2004","journal-title":"Eur Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.eururo.2008.11.009","article-title":"Suburothelial Myofibroblasts in the Human Overactive Bladder and the Effect of Botulinum Neurotoxin Type A Treatment.","volume":"55","author":"A Roosen","year":"2009","journal-title":"Eur Urol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/S0022-5347(05)65005-7","article-title":"A comparison of multiple urine markers for interstitial cystitis.","volume":"167","author":"DR Erickson","year":"2002","journal-title":"J Urol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0022-5347(05)65466-3","article-title":"Over expression of platelet-derived endothelial cell growth factor\/thymidine phosphorylase in patients with interstitial cystitis and bladder carcinoma.","volume":"167","author":"T Ueda","year":"2002","journal-title":"J Urol"},{"key":"ref9","article-title":"Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study.","author":"P Tyagi","year":"2009","journal-title":"Int Urol Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.urology.2006.08.1109","article-title":"The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.","volume":"69","author":"GR Sant","year":"2007","journal-title":"Urology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000320556","article-title":"TNF increases expression of IL-4 and PARs in mast cells.","volume":"26","author":"H Zhang","year":"2010","journal-title":"Cell Physiol Biochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.urology.2005.07.049","article-title":"Human detrusor smooth muscle cells release interleukin-6, interleukin-8, and RANTES in response to proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha.","volume":"67","author":"K Bouchelouche","year":"2006","journal-title":"Urology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2490-7-7","article-title":"Bladder inflammatory transcriptome in response to tachykinins: neurokinin 1 receptor-dependent genes and transcription regulatory elements.","volume":"7","author":"R Saban","year":"2007","journal-title":"BMC Urol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e10882","DOI":"10.1371\/journal.pone.0010882","article-title":"Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections.","volume":"5","author":"A Oberbach","year":"2010","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/jcp.21412","article-title":"TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling.","volume":"216","author":"C Tacheau","year":"2008","journal-title":"J Cell Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11060-007-9462-8","article-title":"Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells.","volume":"86","author":"A Haghikia","year":"2008","journal-title":"J Neurooncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ejcb.2009.08.003","article-title":"TGF-beta1 down-regulates connexin 43 expression and gap junction intercellular communication in rat hepatic stellate cells.","volume":"88","author":"MC Lim","year":"2009","journal-title":"Eur J Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1242\/jcs.03320","article-title":"Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration.","volume":"119","author":"R Mori","year":"2006","journal-title":"J Cell Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejcb.2005.11.007","article-title":"Up-regulation of connexin43 correlates with increased synthetic activity and enhanced contractile differentiation in TGF-beta-treated human aortic smooth muscle cells.","volume":"85","author":"A Rama","year":"2006","journal-title":"Eur J Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergencyto.2008.02.015","article-title":"Anti- and proinflammatory cytokine gene polymorphism and genetic predisposition: association with smoking, tumor stage and grade, and bacillus Calmette-Guerin immunotherapy in bladder cancer.","volume":"184","author":"D Ahirwar","year":"2008","journal-title":"Cancer Genet Cytogenet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ccr.2005.10.001","article-title":"Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression.","volume":"8","author":"S Varambally","year":"2005","journal-title":"Cancer Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/abbi.2000.2131","article-title":"Regulation of gap junctions by phosphorylation of connexins.","volume":"384","author":"PD Lampe","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/ard.56.7.426","article-title":"Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor.","volume":"56","author":"DL Mattey","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15419060802198736","article-title":"Connexin43 expression levels influence intercellular coupling and cell proliferation of native murine cardiac fibroblasts.","volume":"15","author":"Y Zhang","year":"2008","journal-title":"Cell Commun Adhes"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jcb.22554","article-title":"The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells.","volume":"110","author":"S Crespin","year":"2010","journal-title":"J Cell Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/medicina46010001","article-title":"Diversity and properties of connexin gap junction channels.","volume":"46","author":"M Rackauskas","year":"2010","journal-title":"Medicina (Kaunas)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"C1366","DOI":"10.1152\/ajpcell.00027.2006","article-title":"Gap junction channel activity in short-term cultured human detrusor myocyte cell pairs: gating and unitary conductances.","volume":"291","author":"HZ Wang","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/019131201300004672","article-title":"The myofibroblast: an assessment of controversial issues and a definition useful in diagnosis and research.","volume":"25","author":"B Eyden","year":"2001","journal-title":"Ultrastruct Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.200212079","article-title":"Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan.","volume":"162","author":"AF Muro","year":"2003","journal-title":"J Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/019131290882204","article-title":"Fibroblast phenotype plasticity: relevance for understanding heterogeneity in \u201cfibroblastic\u201d tumors.","volume":"28","author":"B Eyden","year":"2004","journal-title":"Ultrastruct Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1464-410X.2006.05818.x","article-title":"Structural characterization of myofibroblasts in the bladder.","volume":"97","author":"MJ Drake","year":"2006","journal-title":"BJU Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/BJ20051922","article-title":"Life cycle of connexins in health and disease.","volume":"394","author":"DW Laird","year":"2006","journal-title":"Biochem J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.eururo.2007.01.052","article-title":"Cadherin-11 is Expressed in Detrusor Smooth Muscle Cells and Myofibroblasts of Normal Human Bladder.","volume":"52","author":"KA Kuijpers","year":"2007","journal-title":"Eur Urol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.juro.2009.02.148","article-title":"Cadherin-11 up-regulation in overactive bladder suburothelial myofibroblasts.","volume":"182","author":"A Roosen","year":"2009","journal-title":"J Urol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1002\/art.23886","article-title":"Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation.","volume":"58","author":"B Vandooren","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jvs.2006.12.016","article-title":"A novel function for cadherin 11\/osteoblast-cadherin in vascular smooth muscle cells: modulation of cell migration and proliferation.","volume":"45","author":"TS Monahan","year":"2007","journal-title":"J Vasc Surg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/biot.200600092","article-title":"Gap junctional intercellular communication capacity by gap-FRAP technique: a comparative study.","volume":"2","author":"M Abbaci","year":"2007","journal-title":"Biotechnol J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.3961495","article-title":"A fluorescence photobleaching assay of gap junction-mediated communication between human cells.","volume":"232","author":"MH Wade","year":"1986","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S1357-2725(03)00264-4","article-title":"The effects of connexin phosphorylation on gap junctional communication.","volume":"36","author":"PD Lampe","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1083\/jcb.149.7.1503","article-title":"Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.","volume":"149","author":"PD Lampe","year":"2000","journal-title":"J Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1091\/mbc.6.12.1707","article-title":"Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.","volume":"6","author":"BR Kwak","year":"1995","journal-title":"Mol Biol Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.4049\/jimmunol.180.7.4986","article-title":"TLR2 regulates gap junction intercellular communication in airway cells.","volume":"180","author":"FJ Martin","year":"2008","journal-title":"J Immunol"},{"key":"ref43","first-page":"93","article-title":"Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions.","volume":"157","author":"BR Kwak","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"C1648","DOI":"10.1152\/ajpcell.2001.281.5.C1648","article-title":"Endogenous protein phosphatase 1 runs down gap junctional communication of rat ventricular myocytes.","volume":"281","author":"F Duthe","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1074\/jbc.M005847200","article-title":"Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication.","volume":"276","author":"BN Giepmans","year":"2001","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1210\/en.2007-0767","article-title":"Tumor necrosis factor-alpha-induced anterior pituitary folliculostellate TtT\/GF cell uncoupling is mediated by connexin 43 dephosphorylation.","volume":"148","author":"MA Meilleur","year":"2007","journal-title":"Endocrinology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1095\/biolreprod.105.044313","article-title":"Modulation of GJA1 turnover and intercellular communication by proinflammatory cytokines in the anterior pituitary folliculostellate cell line TtT\/GF.","volume":"74","author":"ME Fortin","year":"2006","journal-title":"Biol Reprod"},{"key":"ref48","first-page":"1193","article-title":"[Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells.].","volume":"46","author":"J Neuhaus","year":"2007","journal-title":"Urologe A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0022-5347(05)00167-9","article-title":"Interleukin-4 and 13 Induce the Expression and Release of Monocyte Chemoattractant Protein 1, Interleukin-6 and Stem Cell Factor From Human Detrusor Smooth Muscle Cells: Synergy With Interleukin-1beta and Tumor Necrosis Factor-alpha.","volume":"175","author":"K Bouchelouche","year":"2006","journal-title":"J Urol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2172-9-4","article-title":"Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha.","volume":"9","author":"MR Saban","year":"2008","journal-title":"BMC Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3346\/jkms.2008.23.5.857","article-title":"The effect of interleukin-4 and amphiregulin on the proliferation of human airway smooth muscle cells and cytokine release.","volume":"23","author":"JY Shim","year":"2008","journal-title":"J Korean Med Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/labinvest.2008.61","article-title":"Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway.","volume":"88","author":"L Aoudjehane","year":"2008","journal-title":"Lab Invest"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/ni1540","article-title":"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.","volume":"8","author":"DC Fitzgerald","year":"2007","journal-title":"Nat Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cardiores.2004.07.020","article-title":"Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin.","volume":"64","author":"KE Porter","year":"2004","journal-title":"Cardiovasc Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.yexcr.2007.10.010","article-title":"Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL.","volume":"314","author":"AC Sharrow","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jbbm.2006.11.008","article-title":"Usefulness of the 5\u2032 region of the cDNA encoding acidic ribosomal phosphoprotein P0 conserved among rats, mice, and humans as a standard probe for gene expression analysis in different tissues and animal species.","volume":"70","author":"R Akamine","year":"2007","journal-title":"J Biochem Biophys Methods"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:59:34Z","timestamp":1588993174000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020792"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,2]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020792","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,2]]}}}