{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:26:49Z","timestamp":1768829209536,"version":"3.49.0"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020901","type":"journal-article","created":{"date-parts":[[2011,11,26]],"date-time":"2011-11-26T22:55:16Z","timestamp":1322348116000},"page":"e20901","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head"],"prefix":"10.1371","volume":"6","author":[{"given":"Rika","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Grevengoed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Stempniewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah J.","family":"Andrew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/dvdy.10443","article-title":"Survey of forkhead domain encoding genes in the Drosophila genome: Classification and embryonic expression patterns.","volume":"229","author":"HH Lee","year":"2004","journal-title":"Dev Dyn"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrg2523","article-title":"The evolution of Fox genes and their role in development and disease.","volume":"10","author":"S Hannenhalli","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1242\/dev.000141","article-title":"Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.","volume":"134","author":"AL Ferri","year":"2007","journal-title":"Development"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4419-1599-3_5","article-title":"The cooperative roles of Foxc1 and Foxc2 in cardiovascular development.","volume":"665","author":"T Kume","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.cell.2007.07.024","article-title":"Dedicated epithelial recipient cells determine pigmentation patterns.","volume":"130","author":"L Weiner","year":"2007","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1600-0625.2005.00362.x","article-title":"Learning from nudity: lessons from the nude phenotype.","volume":"14","author":"L Mecklenburg","year":"2005","journal-title":"Exp Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nri1488","article-title":"Forkhead-box transcription factors and their role in the immune system.","volume":"4","author":"PJ Coffer","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrc2223","article-title":"The emerging roles of forkhead box (Fox) proteins in cancer.","volume":"7","author":"SS Myatt","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.gde.2010.06.005","article-title":"The FoxA factors in organogenesis and differentiation.","volume":"20","author":"KH Kaestner","year":"2010","journal-title":"Curr Opin Genet Dev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature03649","article-title":"The initiation of liver development is dependent on Foxa transcription factors.","volume":"435","author":"CS Lee","year":"2005","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13809","DOI":"10.1074\/jbc.M414122200","article-title":"Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.","volume":"280","author":"H Wan","year":"2005","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1101\/gad.1752608","article-title":"Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.","volume":"22","author":"N Gao","year":"2008","journal-title":"Genes Dev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1242\/dev.119.4.1301","article-title":"The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3\/forkhead proteins.","volume":"119","author":"SL Ang","year":"1993","journal-title":"Development"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1242\/dev.119.3.567","article-title":"Postimplantation expression patterns indicate a role for the mouse forkhead\/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm.","volume":"119","author":"AP Monaghan","year":"1993","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1242\/dev.118.1.47","article-title":"Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.","volume":"118","author":"H Sasaki","year":"1993","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0092-8674(94)90522-3","article-title":"HNF-3 beta is essential for node and notochord formation in mouse development.","volume":"78","author":"SL Ang","year":"1994","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0092-8674(94)90523-1","article-title":"The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.","volume":"78","author":"DC Weinstein","year":"1994","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1097-2765(02)00459-8","article-title":"Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.","volume":"9","author":"LA Cirillo","year":"2002","journal-title":"Mol Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1101\/gr.084582.108","article-title":"Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.","volume":"19","author":"J Eeckhoute","year":"2009","journal-title":"Genome Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1101\/gad.12.13.1947","article-title":"pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans.","volume":"12","author":"MA Horner","year":"1998","journal-title":"Genes Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1242\/dev.125.12.2171","article-title":"pha-4 is Ce-fkh-1, a fork head\/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx.","volume":"125","author":"JM Kalb","year":"1998","journal-title":"Development"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0092-8674(89)90133-5","article-title":"The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo.","volume":"57","author":"D Weigel","year":"1989","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1126\/science.1065175","article-title":"Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.","volume":"295","author":"J Gaudet","year":"2002","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1242\/dev.114.1.49","article-title":"Organogenesis in Drosophila melanogaster: embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes.","volume":"114","author":"S Panzer","year":"1992","journal-title":"Development"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/dbio.1999.9560","article-title":"Regulation and function of Scr, exd, and hth in the Drosophila salivary gland.","volume":"217","author":"KD Henderson","year":"2000","journal-title":"Dev Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1083\/jcb.200611155","article-title":"Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death.","volume":"176","author":"C Cao","year":"2007","journal-title":"J Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1242\/dev.127.19.4217","article-title":"Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands.","volume":"127","author":"MM Myat","year":"2000","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1242\/dev.02525","article-title":"Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2.","volume":"133","author":"EW Abrams","year":"2006","journal-title":"Development"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1242\/dev.01863","article-title":"CrebA regulates secretory activity in the Drosophila salivary gland and epidermis.","volume":"132","author":"EW Abrams","year":"2005","journal-title":"Development"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/dbio.2001.0367","article-title":"Salivary gland determination in Drosophila: a salivary-specific, fork head enhancer integrates spatial pattern and allows fork head autoregulation.","volume":"237","author":"B Zhou","year":"2001","journal-title":"Dev Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0965-1748(03)00134-6","article-title":"The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases.","volume":"33","author":"S Takiya","year":"2003","journal-title":"Insect Biochem Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jmb.2006.11.087","article-title":"Specific interactions of the wing domains of FOXA1 transcription factor with DNA.","volume":"366","author":"LA Cirillo","year":"2007","journal-title":"J Mol Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/dvdy.22359","article-title":"In vitro and in vivo characterization of Caenorhabditis elegans PHA-4\/FoxA response elements.","volume":"239","author":"WH Raharjo","year":"2010","journal-title":"Dev Dyn"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1101\/gad.10.1.103","article-title":"Tubulogenesis in Drosophila: a requirement for the trachealess gene product.","volume":"10","author":"DD Isaac","year":"1996","journal-title":"Genes Dev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0012-1606(03)00140-4","article-title":"Specification of cell fates within the salivary gland primordium.","volume":"258","author":"AS Haberman","year":"2003","journal-title":"Dev Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.devcel.2009.11.009","article-title":"Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes.","volume":"18","author":"I Fernandes","year":"2010","journal-title":"Dev Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1083\/jcb.201004062","article-title":"The CrebA\/Creb3-like transcription factors are major and direct regulators of secretory capacity.","volume":"191","author":"RM Fox","year":"2010","journal-title":"J Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.mod.2004.05.006","article-title":"Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed Tkv receptor during early embryogenesis.","volume":"121","author":"S Bartoszewski","year":"2004","journal-title":"Mech Dev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev.cellbio.24.110707.175411","article-title":"The molecular basis of organ formation: insights from the C. elegans foregut.","volume":"25","author":"SE Mango","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1091\/mbc.10.5.1595","article-title":"WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.","volume":"10","author":"P Seshaiah","year":"1999","journal-title":"Mol Biol Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/dbio.2001.0429","article-title":"pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland.","volume":"239","author":"P Seshaiah","year":"2001","journal-title":"Dev Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0012-1606(03)00103-9","article-title":"Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.","volume":"257","author":"PL Bradley","year":"2003","journal-title":"Dev Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/j.1460-2075.1994.tb06362.x","article-title":"Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes.","volume":"13","author":"DJ Andrew","year":"1994","journal-title":"Embo J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.","volume":"118","author":"AH Brand","year":"1993","journal-title":"Development"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery.","volume":"4","author":"G Dennis Jr","year":"2003","journal-title":"Genome Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1242\/dev.112.4.997","article-title":"The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny.","volume":"112","author":"AV Smith","year":"1991","journal-title":"Development"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0012-1606(92)90013-7","article-title":"Regulatory interactions and role in cell type specification of the Malpighian tubules by the cut, Kruppel, and caudal genes of Drosophila.","volume":"150","author":"S Liu","year":"1992","journal-title":"Dev Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e1000222","DOI":"10.1371\/journal.pgen.1000222","article-title":"The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.","volume":"4","author":"RB Smit","year":"2008","journal-title":"PLoS Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ydbio.2006.09.036","article-title":"Gland-specific expression of C. elegans hlh-6 requires the combinatorial action of three distinct promoter elements.","volume":"302","author":"I Raharjo","year":"2007","journal-title":"Dev Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ydbio.2006.11.042","article-title":"PHA-4\/FoxA cooperates with TAM-1\/TRIM to regulate cell fate restriction in the C. elegans foregut.","volume":"303","author":"JC Kiefer","year":"2007","journal-title":"Dev Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1210\/me.2009-0513","article-title":"Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.","volume":"24","author":"N Gao","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1242\/dev.042077","article-title":"Sunspot, a link between Wingless signaling and endoreplication in Drosophila.","volume":"137","author":"K Taniue","year":"2010","journal-title":"Development"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1242\/dev.128.23.4737","article-title":"Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells.","volume":"128","author":"WM Deng","year":"2001","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1101\/gad.200901","article-title":"Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis.","volume":"15","author":"H Lopez-Schier","year":"2001","journal-title":"Genes Dev"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.3.8.1113","article-title":"Structure and distribution of the Notch protein in developing Drosophila.","volume":"3","author":"S Kidd","year":"1989","journal-title":"Genes Dev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0091-679X(08)60933-4","article-title":"In situ hybridization to RNA.","volume":"44","author":"R Lehmann","year":"1994","journal-title":"Methods Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1242\/dev.110.4.1031","article-title":"Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos.","volume":"110","author":"R Reuter","year":"1990","journal-title":"Development"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1242\/dev.124.1.181","article-title":"The Drosophila dCREB-A gene is required for dorsal\/ventral patterning of the larval cuticle.","volume":"124","author":"DJ Andrew","year":"1997","journal-title":"Development"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0091-679X(08)60923-1","article-title":"Immunological methods for mapping protein distributions on polytene chromosomes.","volume":"44","author":"DJ Andrew","year":"1994","journal-title":"Methods Cell Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1242\/dev.02738","article-title":"Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis.","volume":"134","author":"S Shibutani","year":"2007","journal-title":"Development"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T01:36:29Z","timestamp":1639791389000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020901"}},"subtitle":[],"editor":[{"given":"Christos","family":"Samakovlis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,16]]},"references-count":61,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020901","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,16]]}}}