{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:27:23Z","timestamp":1791170843358,"version":"4.1.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020945","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T20:53:24Z","timestamp":1308776004000},"page":"e20945","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":82,"title":["Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses"],"prefix":"10.1371","volume":"6","author":[{"given":"Junqiang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori A.","family":"Yenari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Guo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihai","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2165\/00002018-200831050-00004","article-title":"Use of statins and the risk of Parkinson's disease: a retrospective case-control study in the UK.","volume":"31","author":"C Becker","year":"2008","journal-title":"Drug Saf"},{"key":"ref2","article-title":"Statins: Multiple neuroprotective mechanisms in neurodegenerative diseases.","author":"Q Wang","year":"2010","journal-title":"Exp Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.expneurol.2004.08.020","article-title":"Cellular and synaptic distribution of NR2A and NR2B in macaque monkey and rat hippocampus as visualized with subunit-specific monoclonal antibodies.","volume":"191","author":"WG Janssen","year":"2005","journal-title":"Exp Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2007.09.008","article-title":"Analysis of NR3A receptor subunits in human native NMDA receptors.","volume":"1186","author":"A Nilsson","year":"2007","journal-title":"Brain Res"},{"issue":"Pt 3","key":"ref5","first-page":"721","article-title":"Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1\/5 in cultured mouse cortical neurons.","volume":"499","author":"SP Yu","year":"1997","journal-title":"J Physiol"},{"issue":"5412","key":"ref6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.284.5412.336","article-title":"NMDA receptor-mediated K+ efflux and neuronal apoptosis.","volume":"284","author":"SP Yu","year":"1999","journal-title":"Science"},{"issue":"1\u20132","key":"ref7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-510X(02)00087-4","article-title":"N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease.","volume":"200","author":"H Bi","year":"2002","journal-title":"J Neurol Sci"},{"issue":"26","key":"ref8","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1523\/JNEUROSCI.0408-06.2006","article-title":"Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors.","volume":"26","author":"PL Johnson","year":"2006","journal-title":"J Neurosci"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1460-9568.2008.06031.x","article-title":"Neonatal inflammation produces selective behavioural deficits and alters N-methyl-D-aspartate receptor subunit mRNA in the adult rat brain.","volume":"27","author":"EM Harr\u00e9","year":"2008","journal-title":"Eur J Neurosci"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2006.09.078","article-title":"The NMDA receptor antagonist CPP blocks the effects of predator stress on pCREB in brain regions involved in fearful and anxious behavior.","volume":"1136","author":"J Blundell","year":"2007","journal-title":"Brain Res"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2003.09.016","article-title":"Biochemical and molecular studies of NMDA receptor subunits NR1\/2A\/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology.","volume":"15","author":"AJ Mishizen-Eberz","year":"2004","journal-title":"Neurobiol Dis"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.neurobiolaging.2007.03.014","article-title":"Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease.","volume":"29","author":"SW Tsang","year":"2008","journal-title":"Neurobiol Aging"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuroscience.2004.02.003","article-title":"Blockade of N-methyl-D-aspartate receptors by phencyclidine causes the loss of corticostriatal neurons.","volume":"125","author":"C Wang","year":"2004","journal-title":"Neuroscience"},{"issue":"27","key":"ref14","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.2174\/138161205774414538","article-title":"Dopamine-glutamate interaction and antipsychotics mechanism of action: implication for new pharmacological strategies in psychosis.","volume":"11","author":"A de Bartolomeis","year":"2005","journal-title":"Curr Pharm Des"},{"issue":"17","key":"ref15","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1523\/JNEUROSCI.0792-06.2006","article-title":"Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.","volume":"26","author":"PJ Hallett","year":"2006","journal-title":"J Neurosci"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pharmthera.2004.04.001","article-title":"Rationale for and use of NMDA receptor antagonists in Parkinson's disease.","volume":"102","author":"PJ Hallett","year":"2004","journal-title":"Pharmacol Ther"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1124\/mol.105.016667","article-title":"Loss of synaptic D1 dopamine\/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat.","volume":"69","author":"C Fiorentini","year":"2006","journal-title":"Mol Pharmacol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2005.09.010","article-title":"Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease.","volume":"22","author":"MT Armentero","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.expneurol.2005.08.017","article-title":"Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD.","volume":"196","author":"F Bibbiani","year":"2005","journal-title":"Exp Neurol"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.02.083","article-title":"Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice.","volume":"1037","author":"ML Selley","year":"2005","journal-title":"Brain Res"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/sj.bjp.0706106","article-title":"High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase.","volume":"144","author":"Q Wang","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.expneurol.2008.11.016","article-title":"High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: The association with the up-regulation of NMDA receptor binding in the rat brain.","volume":"216","author":"Q Wang","year":"2009","journal-title":"Exp Neurol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/glia.1106","article-title":"Immune function of microglia.","volume":"36","author":"F Aloisi","year":"2001","journal-title":"Glia"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0301-0082(98)00083-5","article-title":"The role of microglia and macrophages in the pathophysiology of the CNS.","volume":"58","author":"G Stoll","year":"1999","journal-title":"Prog Neurobiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1002\/ana.410440717","article-title":"Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?","volume":"44","author":"EC Hirsch","year":"1998","journal-title":"Ann Neurol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2006.12.003","article-title":"p53 protein, interferongamma, and NF-kappaB levels are elevated in the parkinsonian brain.","volume":"414","author":"M Mogi","year":"2007","journal-title":"Neurosci Lett"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1471-4159.2007.05148.x","article-title":"Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide.","volume":"105","author":"MC Hern\u00e1ndez-Romero","year":"2008","journal-title":"J Neurochem"},{"issue":"43","key":"ref28","doi-asserted-by":"crossref","first-page":"13543","DOI":"10.1523\/JNEUROSCI.4144-09.2009","article-title":"Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.","volume":"29","author":"A Ghosh","year":"2009","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"ref29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.brainres.2005.03.016","article-title":"Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats.","volume":"1045","author":"Q Wang","year":"2005","journal-title":"Brain Res"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.psyneuen.2006.05.008","article-title":"Reproductive experience reduces the sedative, but not anxiolytic effects of diazepam.","volume":"31","author":"EM Byrnes","year":"2006","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2004.10.004","article-title":"Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease.","volume":"144","author":"H Yuan","year":"2005","journal-title":"J Neurosci Methods"},{"key":"ref32","article-title":"The rat brain in stereotaxic coordinates.","author":"G Paxinos","year":"1997"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1471-4159.2008.05588.x","article-title":"Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine.","volume":"107","author":"J Rodriguez-Blanco","year":"2008","journal-title":"J Neurochem"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1128\/MCB.01901-06","article-title":"Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.","volume":"27","author":"J Iida","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0924-977X(00)00094-8","article-title":"Temporal changes of dopaminergic and glutamatergic receptors in 6-hydroxydopamine-treated rat brain.","volume":"10","author":"T Araki","year":"2000","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.neuroscience.2008.08.035","article-title":"Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease.","volume":"156","author":"MT Tadaiesky","year":"2008","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"ref37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-8993(97)00593-3","article-title":"Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze.","volume":"762","author":"EF Espejo","year":"1997","journal-title":"Brain Res"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S1474-4422(08)70214-X","article-title":"Non-dopaminergic treatments in development for Parkinson's disease.","volume":"7","author":"SH Fox","year":"2008","journal-title":"Lancet Neurol"},{"issue":"14","key":"ref39","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/mds.22233","article-title":"Anxiety rating scales in Parkinson's disease: critique and recommendations.","volume":"23","author":"AF Leentjens","year":"2008","journal-title":"Mov Disord"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.expneurol.2003.12.012","article-title":"Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease.","volume":"187","author":"R Betarbet","year":"2004","journal-title":"Exp Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0026-895X(24)23206-5","article-title":"Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease.","volume":"57","author":"AW Dunah","year":"2000","journal-title":"Mol Pharmacol"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/syn.890190405","article-title":"Glutamate\/dopamine D1\/D2 balance in the basal ganglia and its relevance to Parkinson's disease.","volume":"19","author":"MS Starr","year":"1995","journal-title":"Synapse"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1001\/archneur.1991.00530210109030","article-title":"N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease.","volume":"48","author":"JT Greenamyre","year":"1991","journal-title":"Arch Neurol"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1460-9568.2007.05774.x","article-title":"Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes.","volume":"26","author":"S Niemann","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/gps.1093","article-title":"Life long changes in cognitive ability are associated with prescribed medications in old age.","volume":"19","author":"JM Starr","year":"2004","journal-title":"Int J Geriatr Psychiatry"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1212\/01.wnl.0000319647.15752.7b","article-title":"Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study.","volume":"71","author":"C Cramer","year":"2008","journal-title":"Neurology"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/JAD-2008-13209","article-title":"Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease.","volume":"13","author":"CM Carlsson","year":"2008","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0735-1097(03)00785-X","article-title":"Long-term statin use and psychological well-being.","volume":"42","author":"Y Young-Xu","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/1073858405279692","article-title":"Targeting prefrontal cortical dopamine D1 and N-methyl-D-aspartate receptor interactions in schizophrenia treatment.","volume":"11","author":"CR Yang","year":"2005","journal-title":"Neuroscientist"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.neuroscience.2006.06.059","article-title":"Dopamine D1 receptors co-distribute with N-methyl-D- aspartic acid type-1 subunits and modulate synaptically-evoked N-methyl-D-aspartic acid currents in rat basolateral amygdala.","volume":"142","author":"VM Pickel","year":"2006","journal-title":"Neuroscience"},{"issue":"52","key":"ref51","doi-asserted-by":"crossref","first-page":"14259","DOI":"10.1523\/JNEUROSCI.4258-08.2008","article-title":"Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression.","volume":"28","author":"SH Yeh","year":"2008","journal-title":"J Neurosci"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.nbd.2009.07.025","article-title":"Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats.","volume":"36","author":"MA Galic","year":"2009","journal-title":"Neurobiol Dis"},{"issue":"7297","key":"ref53","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature09023","article-title":"The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.","volume":"465","author":"J Sasaki","year":"2010","journal-title":"Nature"},{"issue":"33","key":"ref54","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.1523\/JNEUROSCI.2488-10.2010","article-title":"Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.","volume":"30","author":"P Xia","year":"2010","journal-title":"J Neurosci"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/toxsci\/kfj144","article-title":"Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture.","volume":"91","author":"C Wang","year":"2006","journal-title":"Toxicol Sci"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1083\/jcb.200612097","article-title":"Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage.","volume":"178","author":"L Tian","year":"2007","journal-title":"J Cell Biol"},{"issue":"48","key":"ref57","doi-asserted-by":"crossref","first-page":"20504","DOI":"10.1073\/pnas.0908083106","article-title":"GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo.","volume":"106","author":"NW Hu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"ref58","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1523\/JNEUROSCI.5346-08.2009","article-title":"Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling.","volume":"29","author":"P Michaluk","year":"2009","journal-title":"J Neurosci"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1471-4159.2009.06038.x","article-title":"Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors.","volume":"109","author":"D Wheeler","year":"2009","journal-title":"J Neurochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:22:52Z","timestamp":1741270972000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020945"}},"subtitle":[],"editor":[{"given":"Joao B.","family":"Calixto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,22]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020945","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,22]]}}}