{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:55:49Z","timestamp":1791114949416,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T00:00:00Z","timestamp":1308096000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020964","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:57:10Z","timestamp":1308344230000},"page":"e20964","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Potential Involvement of LOX-1 in Functional Consequences of Endothelial Senescence"],"prefix":"10.1371","volume":"6","author":[{"given":"Magomed","family":"Khaidakov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawahar L.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00424-010-0860-y","article-title":"Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis.","volume":"460","author":"M Barton","year":"2010","journal-title":"Pflugers Arch"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-5793(02)02902-2","article-title":"Increased early atherogenesis in young versus old hypercholesterolemic rabbits by a mechanism independent of arterial cell proliferation.","volume":"522","author":"MJ Cortes","year":"2002","journal-title":"FEBS Lett"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000112133","article-title":"Effect of Aging on Fatty Streak Formation in a Diet-Induced Mouse Model of Atherosclerosis.","volume":"45","author":"Y Li","year":"2008","journal-title":"J Vasc Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1474-9726.2008.00438.x","article-title":"Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.","volume":"7","author":"AJ Donato","year":"2008","journal-title":"Aging Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00391-007-0482-y","article-title":"Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase.","volume":"40","author":"S Jakob","year":"2007","journal-title":"Z Gerontol Geriatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.RES.0000258450.44413.96","article-title":"Mitochondrial dysfunction in atherosclerosis.","volume":"100","author":"NR Madamanchi","year":"2007","journal-title":"Circ Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.mad.2007.09.006","article-title":"Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors.","volume":"128","author":"G Voghel","year":"2007","journal-title":"Mech Ageing Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1139\/Y08-082","article-title":"Stress-induced senescence predominates in endothelial cells isolated from atherosclerotic chronic smokers.","volume":"86","author":"N Farhat","year":"2008","journal-title":"Can J Physiol Pharmacol"},{"key":"ref9","first-page":"193","article-title":"Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease.","volume":"70","author":"P Holvoet","year":"2008","journal-title":"Verh K Acad Geneeskd Belg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cardiores.2005.09.006","article-title":"Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders.","volume":"69","author":"JL Mehta","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0008-6363(01)00371-6","article-title":"Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation.","volume":"52","author":"DY Li","year":"2001","journal-title":"Cardiovasc Res"},{"key":"ref12","first-page":"1553","article-title":"Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells.","volume":"123","author":"JW Chen","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"ref13","first-page":"88","article-title":"Apoptosis and proliferative activity of hepatocytes of white rats during aging.","volume":"174","author":"S Giorgadze","year":"2009","journal-title":"Georgian Med News"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.freeradbiomed.2007.08.028","article-title":"Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid.","volume":"43","author":"J Tamilselvan","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0531-5565(99)00045-5","article-title":"Ceroid\/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress.","volume":"34","author":"A Terman","year":"1999","journal-title":"Exp Gerontol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1074\/jbc.275.17.12633","article-title":"Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species.","volume":"275","author":"L Cominacini","year":"2000","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/01.RES.87.7.540","article-title":"Nitric oxide activates telomerase and delays endothelial cell senescence.","volume":"87","author":"M Vasa","year":"2000","journal-title":"Circ Res"},{"issue":"Pt 20","key":"ref18","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1242\/jcs.113.20.3613","article-title":"Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells.","volume":"113","author":"DJ Kurz","year":"2000","journal-title":"J Cell Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1093\/emboj\/cdg417","article-title":"Reversal of human cellular senescence: roles of the p53 and p16 pathways.","volume":"22","author":"CM Beaus\u00e9jour","year":"2003","journal-title":"EMBO J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1253\/circj.CJ-10-0916","article-title":"Role of cellular senescence in lifestyle-related disease.","volume":"74","author":"T Minamino","year":"2010","journal-title":"Circ J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0021-9150(99)00482-7","article-title":"Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis.","volume":"152","author":"K Okuda","year":"2000","journal-title":"Atherosclerosis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/01.CIR.99.1.111","article-title":"Age-Dependent Impairment of Angiogenesis.","volume":"99","author":"A Rivard","year":"1999","journal-title":"Circulation"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2174\/156652408786733685","article-title":"Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1.","volume":"8","author":"MR Hoenig","year":"2008","journal-title":"Curr Mol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1253\/circj.CJ-09-0587","article-title":"LOX-1: the multifunctional receptor underlying cardiovascular dysfunction.","volume":"73","author":"S Ogura","year":"2009","journal-title":"Circ J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/ATVBAHA.107.152272","article-title":"Small concentrations of oxLDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway.","volume":"27","author":"A Dandapat","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/HYPERTENSIONAHA.107.096446","article-title":"Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.","volume":"50","author":"C Hu","year":"2007","journal-title":"Hypertension"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/01.RES.0000113782.07824.BE","article-title":"Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells.","volume":"94","author":"J Chen","year":"2004","journal-title":"Circ Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/hh2001.097796","article-title":"Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide.","volume":"89","author":"J Hoffmann","year":"2001","journal-title":"Circ Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/138161208783413248","article-title":"Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model.","volume":"14","author":"N Vannini","year":"2008","journal-title":"Curr Pharm Des"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1096\/fasebj.9.10.7542214","article-title":"Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.","volume":"9","author":"T Collins","year":"1995","journal-title":"FASEB J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/mvre.1995.1064","article-title":"Expression of adhesion molecules in cultured human pulmonary microvascular endothelial cells.","volume":"50","author":"J Shen","year":"1995","journal-title":"Microvasc Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1152\/physiolgenomics.00009.2010","article-title":"Genomics of cardiac remodeling in angiotensin II - treated wild-type and LOX-1-deficient mice.","volume":"42","author":"BY Kang","year":"2010","journal-title":"Physiol Genomics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T13:48:46Z","timestamp":1637848126000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020964"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Novelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,15]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020964","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,15]]}}}