{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:58:42Z","timestamp":1788472722928,"version":"build-2803163510"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0021412","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T21:02:41Z","timestamp":1308862961000},"page":"e21412","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular and Cellular Characterization of an AT-Hook Protein from Leishmania"],"prefix":"10.1371","volume":"6","author":[{"given":"Ben L.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanendra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Aiyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1112680","article-title":"The genome of the kinetoplastid parasite, Leishmania major.","volume":"309","author":"AC Ivens","year":"2005","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1097-2765(03)00143-6","article-title":"Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region.","volume":"11","author":"S Martinez-Calvillo","year":"2003","journal-title":"Mol Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2164-10-152","article-title":"Histone acetylations mark origins of polycistronic transcription in Leishmania major.","volume":"10","author":"S Thomas","year":"2009","journal-title":"BMC Genomics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s002940100246","article-title":"Secondary DNA structure analysis of the coding strand switch regions of five Leishmania major Friedlin chromosomes.","volume":"40","author":"V Tosato","year":"2001","journal-title":"Curr Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2164-8-57","article-title":"Compared genomics of the strand switch region of Leishmania chromosome 1 reveal a novel genus-specific gene and conserved structural features and sequence motifs.","volume":"8","author":"J Puechberty","year":"2007","journal-title":"BMC Genomics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"32184","DOI":"10.1074\/jbc.M505600200","article-title":"Inhibition of nucleotide excision repair by high mobility group protein HMGA1.","volume":"280","author":"JE Adair","year":"2005","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1073\/pnas.96.6.2656","article-title":"The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks.","volume":"96","author":"RY Chuang","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.dnarep.2005.04.010","article-title":"Role of high mobility group (HMG) chromatin proteins in DNA repair.","volume":"4","author":"R Reeves","year":"2005","journal-title":"DNA Repair (Amst)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1073\/pnas.0707260105","article-title":"Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins.","volume":"105","author":"AW Thomae","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jmb.2008.09.015","article-title":"Assembling the human IFN-beta enhanceosome in solution.","volume":"384","author":"AI Dragan","year":"2008","journal-title":"J Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1097-2765(00)80013-1","article-title":"The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome.","volume":"1","author":"TK Kim","year":"1997","journal-title":"Mol Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"13589","DOI":"10.1073\/pnas.251530398","article-title":"The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein.","volume":"98","author":"JK Lee","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1038\/emboj.2008.221","article-title":"RNA-dependent recruitment of the origin recognition complex.","volume":"27","author":"J Norseen","year":"2008","journal-title":"EMBO J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-1119(01)00689-8","article-title":"Molecular biology of HMGA proteins: hubs of nuclear function.","volume":"277","author":"R Reeves","year":"2001","journal-title":"Gene"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1016\/S0021-9258(19)38926-4","article-title":"The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.","volume":"265","author":"R Reeves","year":"1990","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nsb0897-657","article-title":"The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.","volume":"4","author":"JR Huth","year":"1997","journal-title":"Nat Struct Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.biophys.27.1.105","article-title":"Minor groove-binding architectural proteins: structure, function, and DNA recognition.","volume":"27","author":"CA Bewley","year":"1998","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/MCB.15.1.456","article-title":"Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential.","volume":"15","author":"LA Dickinson","year":"1995","journal-title":"Mol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11487","DOI":"10.1128\/JVI.78.21.11487-11505.2004","article-title":"The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomes.","volume":"78","author":"J Sears","year":"2004","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/gb-2009-10-3-214","article-title":"The origin recognition complex protein family.","volume":"10","author":"BP Duncker","year":"2009","journal-title":"Genome Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1128\/JVI.02578-08","article-title":"Optimal transactivation by Epstein-Barr nuclear antigen 1 requires the UR1 and ATH1 domains.","volume":"83","author":"G Singh","year":"2009","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/366087a0","article-title":"Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.","volume":"366","author":"G Micklem","year":"1993","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1126\/science.8266071","article-title":"Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.","volume":"262","author":"M Foss","year":"1993","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S1097-2765(00)00100-3","article-title":"Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster.","volume":"6","author":"S Janssen","year":"2000","journal-title":"Mol Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1038\/sj.emboj.7601125","article-title":"Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide.","volume":"25","author":"R Blattes","year":"2006","journal-title":"EMBO J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1093\/emboj\/17.7.2079","article-title":"In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation.","volume":"17","author":"F Girard","year":"1998","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/embo-reports\/kvf155","article-title":"Modification of position-effect variegation by competition for binding to Drosophila satellites.","volume":"3","author":"C Monod","year":"2002","journal-title":"EMBO Rep"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4161\/epi.5.7.12856","article-title":"Reading chromatin: Insights from yeast into YEATS domain structure and function.","volume":"5","author":"JM Schulze","year":"2010","journal-title":"Epigenetics"},{"key":"ref29","first-page":"65","article-title":"YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.","volume":"87","author":"JM Schulze","year":"2009","journal-title":"Biochem Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.0900604106","article-title":"Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs.","volume":"106","author":"S Kosugi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"W321","DOI":"10.1093\/nar\/gkh377","article-title":"The PredictProtein server.","volume":"32","author":"B Rost","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"W585","DOI":"10.1093\/nar\/gkm259","article-title":"WoLF PSORT: protein localization predictor.","volume":"35","author":"P Horton","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1084\/jem.20060559","article-title":"A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes.","volume":"203","author":"C Huynh","year":"2006","journal-title":"J Exp Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0166-6851(01)00307-3","article-title":"Stage-specific expression in Leishmania conferred by 3\u2032 untranslated regions of L. major leishmanolysin genes (GP63).","volume":"116","author":"BL Kelly","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"37789","DOI":"10.1074\/jbc.M002149200","article-title":"The immunologically protective P-4 antigen of Leishmania amastigotes. A developmentally regulated single strand-specific nuclease associated with the endoplasmic reticulum.","volume":"275","author":"S Kar","year":"2000","journal-title":"J Biol Chem"},{"key":"ref36","first-page":"6719","article-title":"Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acid.","volume":"249","author":"RM Wartell","year":"1974","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1073\/pnas.84.13.4359","article-title":"Origins of netropsin binding affinity and specificity: correlations of thermodynamic and structural data.","volume":"84","author":"LA Marky","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/0006-291X(90)90981-R","article-title":"Netropsin, distamycin and berenil interact differentially with a high-affinity binding site for the high mobility group protein HMG-I.","volume":"166","author":"M Wegner","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.exppara.2006.11.002","article-title":"Histone H1 regulates chromatin condensation in Leishmania parasites.","volume":"116","author":"S Masina","year":"2007","journal-title":"Exp Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1365-2958.2006.05205.x","article-title":"Leishmania histone H1 overexpression delays parasite cell-cycle progression, parasite differentiation and reduces Leishmania infectivity in vivo.","volume":"60","author":"D Smirlis","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0300-9084(79)80455-1","article-title":"Studies on the preferential binding of histone H1 to AT-rich DNA.","volume":"60","author":"LN Marekov","year":"1978","journal-title":"Biochimie"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1128\/MCB.19.4.2803","article-title":"Specific binding of high-mobility-group I (HMGI) protein and histone H1 to the upstream AT-rich region of the murine beta interferon promoter: HMGI protein acts as a potential antirepressor of the promoter.","volume":"19","author":"E Bonnefoy","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/j.1460-2075.1993.tb05993.x","article-title":"SAR-dependent mobilization of histone H1 by HMG-I\/Y in vitro: HMG-I\/Y is enriched in H1-depleted chromatin.","volume":"12","author":"K Zhao","year":"1993","journal-title":"EMBO J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1083\/jcb.109.5.1975","article-title":"High-mobility group protein HMG-I localizes to G\/Q- and C-bands of human and mouse chromosomes.","volume":"109","author":"JE Disney","year":"1989","journal-title":"J Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(94)90502-9","article-title":"Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold.","volume":"76","author":"Y Saitoh","year":"1994","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1101\/SQB.1993.058.01.083","article-title":"From the chromosomal loops and the scaffold to the classic bands of metaphase chromosomes.","volume":"58","author":"Y Saitoh","year":"1993","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"11767","DOI":"10.1128\/JVI.77.21.11767-11780.2003","article-title":"Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1.","volume":"77","author":"J Sears","year":"2003","journal-title":"J Virol"},{"key":"ref48","first-page":"85","article-title":"Plasmid origin of replication of Epstein-Barr virus, oriP, does not limit replication in cis.","volume":"5","author":"B Sugden","year":"1988","journal-title":"Mol Biol Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0042-6822(03)00122-3","article-title":"The spacing between adjacent binding sites in the family of repeats affects the functions of Epstein-Barr nuclear antigen 1 in transcription activation and stable plasmid maintenance.","volume":"311","author":"C Hebner","year":"2003","journal-title":"Virology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1743-422X-6-29","article-title":"Epstein-Barr Nuclear Antigen 1 modulates replication of oriP-plasmids by impeding replication and transcription fork migration through the family of repeats.","volume":"6","author":"A Aiyar","year":"2009","journal-title":"Virol J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1128\/JVI.65.3.1466-1478.1991","article-title":"Functional domains of Epstein-Barr virus nuclear antigen EBNA-1.","volume":"65","author":"RF Ambinder","year":"1991","journal-title":"J Virol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1128\/MCB.5.8.1822","article-title":"A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.","volume":"5","author":"D Reisman","year":"1985","journal-title":"Mol Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1128\/MCB.5.10.2533","article-title":"Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells.","volume":"5","author":"S Lupton","year":"1985","journal-title":"Mol Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/282039a0","article-title":"Isolation and characterisation of a yeast chromosomal replicator.","volume":"282","author":"DT Stinchcomb","year":"1979","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/MCB.9.3.1026","article-title":"Isolation of human sequences that replicate autonomously in human cells.","volume":"9","author":"PJ Krysan","year":"1989","journal-title":"Mol Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1093\/emboj\/17.21.6394","article-title":"The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element.","volume":"17","author":"A Aiyar","year":"1998","journal-title":"EMBO J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1091\/mbc.4.11.1121","article-title":"Autonomous replication of human chromosomal DNA fragments in human cells.","volume":"4","author":"H Masukata","year":"1993","journal-title":"Mol Biol Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF00282474","article-title":"Post-transcriptional regulation in higher eukaryotes: the role of the reporter gene in controlling expression.","volume":"228","author":"DR Gallie","year":"1991","journal-title":"Mol Gen Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.1016\/S0021-9258(18)81647-7","article-title":"Protein denaturation during heat shock and related stress. Escherichia coli beta-galactosidase and Photinus pyralis luciferase inactivation in mouse cells.","volume":"264","author":"VT Nguyen","year":"1989","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-1119(91)90270-L","article-title":"Modulation of firefly luciferase stability and impact on studies of gene regulation.","volume":"103","author":"JF Thompson","year":"1991","journal-title":"Gene"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1126\/science.6251547","article-title":"Isolation of mutants of an animal virus in bacteria.","volume":"209","author":"KW Peden","year":"1980","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1038\/sj.emboj.7601853","article-title":"The coupling of synthesis and partitioning of EBV&apos;s plasmid replicon is revealed in live cells.","volume":"26","author":"A Nanbo","year":"2007","journal-title":"EMBO J"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1128\/JVI.69.2.1280-1283.1995","article-title":"Plasmid maintenance of derivatives of oriP of Epstein-Barr virus.","volume":"69","author":"AL Kirchmaier","year":"1995","journal-title":"J Virol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S1097-2765(00)00099-X","article-title":"Chromatin opening of DNA satellites by targeted sequence-specific drugs.","volume":"6","author":"S Janssen","year":"2000","journal-title":"Mol Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","article-title":"Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery.","volume":"276","author":"S Futaki","year":"2001","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1074\/jbc.M110017200","article-title":"Possible existence of common internalization mechanisms among arginine-rich peptides.","volume":"277","author":"T Suzuki","year":"2002","journal-title":"J Biol Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.yexcr.2005.04.004","article-title":"Dynamic mitochondrial localization of nuclear transcription factor HMGA1.","volume":"307","author":"GA Dement","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e8004","DOI":"10.1371\/journal.pone.0008004","article-title":"HMGA1a recognition candidate DNA sequences in humans.","volume":"4","author":"T Manabe","year":"2009","journal-title":"PLoS One"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0092-8674(95)90140-X","article-title":"SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein.","volume":"83","author":"R Strick","year":"1995","journal-title":"Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"13059","DOI":"10.1021\/bi701269s","article-title":"Specific recognition of AT-rich DNA sequences by the mammalian high mobility group protein AT-hook 2: a SELEX study.","volume":"46","author":"T Cui","year":"2007","journal-title":"Biochemistry"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"22563","DOI":"10.1074\/jbc.274.32.22563","article-title":"Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.","volume":"274","author":"S Nagpal","year":"1999","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"27494","DOI":"10.1016\/S0021-9258(19)61535-8","article-title":"The high mobility group I\/Y protein is hypophosphorylated in endoreduplicating maize endosperm cells and is involved in alleviating histone H1-mediated transcriptional repression.","volume":"275","author":"J Zhao","year":"2000","journal-title":"J Biol Chem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1128\/MCB.24.21.9424-9436.2004","article-title":"The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres.","volume":"24","author":"H Zhang","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1084\/jem.20031162","article-title":"Leishmania major LACK antigen is required for efficient vertebrate parasitization.","volume":"198","author":"BL Kelly","year":"2003","journal-title":"J Exp Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0166-6851(01)00432-7","article-title":"Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.","volume":"120","author":"PB Joshi","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1128\/IAI.72.12.6924-6931.2004","article-title":"The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB\/c mice.","volume":"72","author":"BL Kelly","year":"2004","journal-title":"Infect Immun"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.4049\/jimmunol.165.7.3985","article-title":"Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha.","volume":"165","author":"M Giroux","year":"2000","journal-title":"J Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"e1000469","DOI":"10.1371\/journal.ppat.1000469","article-title":"Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1.","volume":"5","author":"S Aras","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0166-6851(96)02801-0","article-title":"Histone H1 expression varies during the Leishmania major life cycle.","volume":"84","author":"TM Noll","year":"1997","journal-title":"Mol Biochem Parasitol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0021412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T07:23:32Z","timestamp":1637911412000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0021412"}},"subtitle":[],"editor":[{"given":"Julio Francisco","family":"Turrens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,23]]},"references-count":79,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0021412","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,23]]}}}