{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:04:15Z","timestamp":1761919455394},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0021625","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T17:03:34Z","timestamp":1309367014000},"page":"e21625","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The In Vivo Role of the RP-Mdm2-p53 Pathway in Signaling Oncogenic Stress Induced by pRb Inactivation and Ras Overexpression"],"prefix":"10.1371","volume":"6","author":[{"given":"Wenqi","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Issaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1126\/science.1905840","article-title":"p53 mutations in human cancers.","volume":"253","author":"M Hollstein","year":"1991","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network.","volume":"408","author":"B Vogelstein","year":"2000","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/bies.950151008","article-title":"The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?","volume":"15","author":"SM Picksley","year":"1993","journal-title":"Bioessays"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1535-6108(03)00134-X","article-title":"Regulation of HDM2 activity by the ribosomal protein L11.","volume":"3","author":"MA Lohrum","year":"2003","journal-title":"Cancer Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"44475","DOI":"10.1074\/jbc.M403722200","article-title":"Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5.","volume":"279","author":"MS Dai","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1128\/MCB.24.17.7654-7668.2004","article-title":"Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.","volume":"24","author":"MS Dai","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1128\/MCB.24.17.7669-7680.2004","article-title":"Inhibition of HDM2 and activation of p53 by ribosomal protein L23.","volume":"24","author":"A Jin","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2007.07.007","article-title":"Balanced production of ribosomal proteins.","volume":"401","author":"RP Perry","year":"2007","journal-title":"Gene"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccr.2009.09.024","article-title":"Signaling to p53: Ribosomal Proteins Find Their Way.","volume":"16","author":"YP Zhang","year":"2009","journal-title":"Cancer Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1128\/MCB.01307-06","article-title":"Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.","volume":"27","author":"MS Lindstrom","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ccr.2010.08.007","article-title":"An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.","volume":"18","author":"E Macias","year":"2010","journal-title":"Cancer Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ncb1225","article-title":"c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.","volume":"7","author":"A Arabi","year":"2005","journal-title":"Nature Cell Biology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"295-U109","DOI":"10.1038\/ncb1223","article-title":"Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.","volume":"7","author":"SS Grewal","year":"2005","journal-title":"Nature Cell Biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/emboj\/20.6.1383","article-title":"N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis.","volume":"20","author":"K Boon","year":"2001","journal-title":"Embo Journal"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1073\/pnas.97.7.3260","article-title":"Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.","volume":"97","author":"HA Coller","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref16","first-page":"5922","article-title":"Identification of c-Myc responsive genes using rat cDNA microarray.","volume":"60","author":"QM Guo","year":"2000","journal-title":"Cancer Research"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1073\/pnas.082005599","article-title":"Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes.","volume":"99","author":"A Menssen","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nature01327","article-title":"Direct activation of RNA polymerase III transcription by c-Myc.","volume":"421","author":"N Gomez-Roman","year":"2003","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1101\/gad.13.20.2658","article-title":"Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.","volume":"13","author":"CM Eischen","year":"1999","journal-title":"Genes & Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.95.14.8292","article-title":"Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.","volume":"95","author":"T Kamijo","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0092-8674(00)81401-4","article-title":"ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.","volume":"92","author":"YP Zhang","year":"1998","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0092-8674(00)81400-2","article-title":"The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2&apos;s inhibition of p53.","volume":"92","author":"J Pomerantz","year":"1998","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1093\/emboj\/17.17.5001","article-title":"The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.","volume":"17","author":"FJ Stott","year":"1998","journal-title":"Embo Journal"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/25867","article-title":"p14ARF links the tumour suppressors RB and p53.","volume":"395","author":"S Bates","year":"1998","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)80452-3","article-title":"Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.","volume":"91","author":"T Kamijo","year":"1997","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1073\/pnas.091100298","article-title":"Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation.","volume":"98","author":"AW Lin","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1128\/MCB.22.1.370-377.2002","article-title":"p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo.","volume":"22","author":"D Tolbert","year":"2002","journal-title":"Molecular and Cellular Biology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/embo-reports\/kve020","article-title":"p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes.","volume":"2","author":"E Roper","year":"2001","journal-title":"EMBO Rep"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.yexcr.2006.01.027","article-title":"Involvement of the transcriptional factor E2F1 in the regulation of the rRNA promoter.","volume":"312","author":"O Ayrault","year":"2006","journal-title":"Experimental Cell Research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1101\/gad.1228804","article-title":"A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size.","volume":"18","author":"P Jorgensen","year":"2004","journal-title":"Genes Dev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1128\/MCB.24.1.200-216.2004","article-title":"mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1\/eukaryotic translation initiation factor 4E.","volume":"24","author":"DC Fingar","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"10243","DOI":"10.1158\/0008-5472.CAN-05-1579","article-title":"Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model.","volume":"65","author":"R Hill","year":"2005","journal-title":"Cancer Res"},{"key":"ref33","first-page":"81","article-title":"pRB, p107 and the regulation of the E2F transcription factor.","volume":"Sci","author":"N Dyson","year":"1994","journal-title":"J Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1158\/0008-5472.CAN-06-0486","article-title":"Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.","volume":"66","author":"ZX Zhou","year":"2006","journal-title":"Cancer Research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2005.09.030","article-title":"Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.","volume":"123","author":"R Hill","year":"2005","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/25870","article-title":"p19ARF links the tumour suppressor p53 to Ras.","volume":"395","author":"I Palmero","year":"1998","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1101\/gad.12.15.2424","article-title":"Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.","volume":"12","author":"F Zindy","year":"1998","journal-title":"Genes Dev"},{"key":"ref38","first-page":"3369","article-title":"P53 Is Mutated in a Subset of Advanced-Stage Prostate Cancers.","volume":"53","author":"R Bookstein","year":"1993","journal-title":"Cancer Research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0022-5347(01)67065-4","article-title":"Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer.","volume":"154","author":"HB Heidenberg","year":"1995","journal-title":"J Urol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc969","article-title":"Targeting ras signalling pathways in cancer therapy.","volume":"3","author":"J Downward","year":"2003","journal-title":"Nature Reviews Cancer"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","article-title":"Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.","volume":"23","author":"DC Fingar","year":"2004","journal-title":"Oncogene"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"162s","DOI":"10.1111\/1523-1747.ep12540999","article-title":"Transformation of epidermal cells in culture.","volume":"81","author":"SH Yuspa","year":"1983","journal-title":"J Invest Dermatol"},{"key":"ref43","first-page":"435","article-title":"In vivo behavior of murine epidermal cell lines derived from initiated and noninitiated skin.","volume":"48","author":"CJ Conti","year":"1988","journal-title":"Cancer Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1593\/neo.92030","article-title":"Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.","volume":"12","author":"DE Bassi","year":"2010","journal-title":"Neoplasia"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The C-Myc Oncogene Driven by Immunoglobulin Enhancers Induces Lymphoid Malignancy in Transgenic Mice.","volume":"318","author":"JM Adams","year":"1985","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis.","volume":"126","author":"K Bensaad","year":"2006","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1128\/MCB.01284-09","article-title":"Mitochondrial HEP27 Is a c-Myb Target Gene That Inhibits Mdm2 and Stabilizes p53.","volume":"30","author":"C Deisenroth","year":"2010","journal-title":"Molecular and Cellular Biology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0021625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T20:57:30Z","timestamp":1540241850000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0021625"}},"subtitle":[],"editor":[{"given":"Gen Sheng","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,29]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0021625","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,29]]}}}