{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:29Z","timestamp":1787021849564,"version":"build-2736575974"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0021950","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T16:57:18Z","timestamp":1310662638000},"page":"e21950","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genomic Expression Libraries for the Identification of Cross-Reactive Orthopoxvirus Antigens"],"prefix":"10.1371","volume":"6","author":[{"given":"Lilija","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hapke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Nitsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"ref1","first-page":"2946","article-title":"Poxviruses.","author":"IK Damon","year":"2006"},{"key":"ref2","first-page":"2905","article-title":"Poxviridae: The Viruses and Their Replication.","author":"B Moss","year":"2006"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1128\/JVI.80.5.2127-2140.2006","article-title":"Vaccinia virus proteome: identification of proteins in vaccinia virus intracellular mature virion particles.","volume":"80","author":"CS Chung","year":"2006","journal-title":"J Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vetmic.2009.08.026","article-title":"Zoonotic poxviruses.","volume":"140","author":"S Essbauer","year":"2010","journal-title":"Vet Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.4161\/hv.10295","article-title":"Smallpox vaccines: New formulations and revised strategies for vaccination.","volume":"5","author":"N Paran","year":"2009","journal-title":"Hum Vaccin"},{"key":"ref6","article-title":"The Orthopoxviruses","author":"F Fenner","year":"1989"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(06)68143-9","article-title":"Smallpox.","volume":"367","author":"ZS Moore","year":"2006","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/375824","article-title":"Smallpox vaccination: a review, part I. Background, vaccination technique, normal vaccination and revaccination, and expected normal reactions.","volume":"37","author":"VA Fulginiti","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1086\/375825","article-title":"Smallpox vaccination: a review, part II. Adverse events.","volume":"37","author":"VA Fulginiti","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.coi.2009.04.004","article-title":"The immunology of smallpox vaccines.","volume":"21","author":"RB Kennedy","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","article-title":"Poxvirus genomes: a phylogenetic analysis.","volume":"85","author":"C Gubser","year":"2004","journal-title":"J Gen Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3201\/eid0812.020089","article-title":"Rat-to-human transmission of Cowpox infection.","volume":"8","author":"TF Wolfs","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"ref13","first-page":"329","article-title":"Cowpox virus infection in pet rat owners: not always immediately recognized.","volume":"106","author":"C Becker","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3201\/eid0911.020814","article-title":"Cowpox with severe generalized eruption, Finland.","volume":"9","author":"PM Pelkonen","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0140-6736(90)92387-W","article-title":"Fatal cowpox-like virus infection transmitted by cat.","volume":"336","author":"AM Eis-Hubinger","year":"1990","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0190-9622(00)90265-2","article-title":"Cowpox virus infection in an 11-year-old girl.","volume":"42","author":"R Wienecke","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/QCO.0b013e3282f44c74","article-title":"Cowpox virus infection: an emerging health threat.","volume":"21","author":"RM Vorou","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"ref18","first-page":"E070419","article-title":"Sporadic human cases of cowpox in Germany.","volume":"12","author":"A Nitsche","year":"2007","journal-title":"Euro Surveill"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.vaccine.2005.11.022","article-title":"Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine.","volume":"24","author":"J Vollmar","year":"2006","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0022-2143(03)00143-4","article-title":"Smallpox vaccines: current and future.","volume":"142","author":"R Bonilla-Guerrero","year":"2003","journal-title":"J Lab Clin Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.virol.2007.09.029","article-title":"Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens.","volume":"371","author":"P Sakhatskyy","year":"2008","journal-title":"Virology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2005.09.056","article-title":"Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host.","volume":"345","author":"M Fang","year":"2006","journal-title":"Virology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1016\/j.vaccine.2005.08.010","article-title":"Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy.","volume":"24","author":"M Otero","year":"2006","journal-title":"Vaccine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.vaccine.2006.10.009","article-title":"A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost.","volume":"25","author":"Y Xiao","year":"2007","journal-title":"Vaccine"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"D73","DOI":"10.1016\/j.vaccine.2009.07.103","article-title":"Smallpox vaccines for biodefense.","volume":"27","author":"RB Kennedy","year":"2009","journal-title":"Vaccine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1017\/S0022172400028291","article-title":"The neutralization of pox viruses. II. Relationships between vaccinia, rabbitpox, cowpox and ectromelia.","volume":"66","author":"TA McNeill","year":"1968","journal-title":"J Hyg (Lond)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/S0022172400022403","article-title":"A comparison of the antigens present on the surface of virus released artificially from chick cells infected with vaccinia virus, and cowpox virus and its white pock mutant.","volume":"70","author":"D Baxby","year":"1972","journal-title":"J Hyg (Lond)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01309377","article-title":"Cross-reactivity between cowpox and vaccinia viruses with monoclonal antibodies. Brief report.","volume":"82","author":"N Kitamoto","year":"1984","journal-title":"Arch Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1006\/viro.1994.1240","article-title":"Epitope detection in the envelope of intracellular naked orthopox viruses and identification of encoding genes.","volume":"200","author":"CP Czerny","year":"1994","journal-title":"Virology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1473-3099(10)70054-2","article-title":"Human cowpox in a veterinary student.","volume":"10","author":"M Glatz","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e6883","DOI":"10.1371\/journal.pone.0006883","article-title":"Cowpox virus outbreak in banded mongooses (Mungos mungo) and jaguarundis (Herpailurus yagouaroundi) with a time-delayed infection to humans.","volume":"4","author":"A Kurth","year":"2009","journal-title":"PLoS ONE"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3201\/eid1505.090159","article-title":"Cowpox virus transmission from pet rats to humans, Germany.","volume":"15","author":"H Campe","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.vaccine.2008.12.035","article-title":"The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays.","volume":"27","author":"JS Duke-Cohan","year":"2009","journal-title":"Vaccine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1073\/pnas.0408782102","article-title":"Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery.","volume":"102","author":"DH Davies","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0378-1119(82)90007-5","article-title":"Representation of DNA sequences in recombinant DNA libraries prepared by restriction enzyme partial digestion.","volume":"19","author":"B Seed","year":"1982","journal-title":"Gene"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1128\/JVI.61.12.3910-3919.1987","article-title":"Structural and functional studies of a 39,000-Mr immunodominant protein of vaccinia virus.","volume":"61","author":"JS Maa","year":"1987","journal-title":"J Virol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.vaccine.2007.11.045","article-title":"Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: intra-nasal vaccination.","volume":"26","author":"S Vijaysri","year":"2008","journal-title":"Vaccine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1128\/JVI.75.2.850-856.2001","article-title":"Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model.","volume":"75","author":"TA Brandt","year":"2001","journal-title":"J Virol"},{"key":"ref39","article-title":"The Role of vaccinia virus genes E3L and K3L and the host genes PKR and RNaseL during intratracheal infection of C57BL\/6 mice.","author":"AD Rice","year":"2010","journal-title":"J Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/pmic.200600926","article-title":"Proteome-wide analysis of the serological response to vaccinia and smallpox.","volume":"7","author":"DH Davies","year":"2007","journal-title":"Proteomics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/eji.200535538","article-title":"Rapid molecular dissection of viral and bacterial immunomes.","volume":"36","author":"U Sahin","year":"2006","journal-title":"Eur J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"D854","DOI":"10.1093\/nar\/gkp1004","article-title":"The immune epitope database 2.0.","volume":"38","author":"R Vita","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.0105-2896.2006.00392.x","article-title":"Immunity and immunological memory following smallpox vaccination.","volume":"211","author":"IJ Amanna","year":"2006","journal-title":"Immunol Rev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2008.04.003","article-title":"Heterogeneity in the A33 protein impacts the cross-protective efficacy of a candidate smallpox DNA vaccine.","volume":"377","author":"JW Golden","year":"2008","journal-title":"Virology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1128\/JVI.00374-07","article-title":"Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6.","volume":"81","author":"L daz-Carroll","year":"2007","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1128\/JVI.77.13.7590-7600.2003","article-title":"Poxvirus orthologous clusters: toward defining the minimum essential poxvirus genome.","volume":"77","author":"C Upton","year":"2003","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3201\/eid1404.070817","article-title":"Rat-to-Elephant-to-Human Transmission of Cowpox Virus.","volume":"14","author":"A Kurth","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1354\/vp.43-2-212","article-title":"Fatal poxvirus outbreak in a colony of New World monkeys.","volume":"43","author":"K Matz-Rensing","year":"2006","journal-title":"Vet Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e10412","DOI":"10.1371\/journal.pone.0010412","article-title":"A novel highly reproducible and lethal nonhuman primate model for orthopox virus infection.","volume":"5","author":"M Kramski","year":"2010","journal-title":"PLoS One"},{"key":"ref50","first-page":"119","article-title":"Orthopoxvirus Diagnostics.","author":"H Meyer","year":"2004"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mcp.2009.10.008","article-title":"Multicolour, multiplex real-time PCR assay for the detection of human-pathogenic poxviruses.","volume":"24","author":"K Schroeder","year":"2009","journal-title":"Mol Cell Probes"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/clinchem\/45.11.1932","article-title":"Different real-time PCR formats compared for the quantitative detection of human cytomegalovirus DNA.","volume":"45","author":"A Nitsche","year":"1999","journal-title":"Clin Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0021950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T05:20:13Z","timestamp":1592716813000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0021950"}},"subtitle":[],"editor":[{"given":"Stephen Mark","family":"Tompkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0021950","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}