{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:37:57Z","timestamp":1790865477934,"version":"4.1.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T00:00:00Z","timestamp":1310083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0022133","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T21:12:42Z","timestamp":1310159562000},"page":"e22133","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["Sexually Dimorphic Serotonergic Dysfunction in a Mouse Model of Huntington's Disease and Depression"],"prefix":"10.1371","volume":"6","author":[{"given":"Thibault","family":"Renoir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Zajac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence Y.","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Leang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Chevarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Lanfumey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.biopsych.2006.11.034","article-title":"Psychiatric symptoms in Huntington&apos;s disease before diagnosis: the predict-HD study.","volume":"62","author":"K Duff","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/jnnp.2006.103309","article-title":"Psychiatric disorders in preclinical Huntington&apos;s disease.","volume":"78","author":"CL Julien","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1001\/archneur.64.1.116","article-title":"Specific psychiatric manifestations among preclinical Huntington disease mutation carriers.","volume":"64","author":"J Marshall","year":"2007","journal-title":"Arch Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1176\/jnp.17.4.496","article-title":"Depression and stages of Huntington&apos;s disease.","volume":"17","author":"JS Paulsen","year":"2005","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0896-6273(00)00112-4","article-title":"Major depressive disorder.","volume":"28","author":"M Fava","year":"2000","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.comppsych.2007.06.012","article-title":"Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression study.","volume":"49","author":"SM Marcus","year":"2008","journal-title":"Compr Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/sj.mp.4001920","article-title":"Serotonergic vulnerability and depression: assumptions, experimental evidence and implications.","volume":"12","author":"LA Jans","year":"2007","journal-title":"Mol Psychiatry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10519-007-9172-1","article-title":"Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR).","volume":"38","author":"BH Brummett","year":"2008","journal-title":"Behav Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/sj.mp.4001555","article-title":"Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden.","volume":"10","author":"HJ Grabe","year":"2005","journal-title":"Mol Psychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jpsychores.2005.06.068","article-title":"Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety.","volume":"60","author":"T Mizuno","year":"2006","journal-title":"J Psychosom Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S1461145705005936","article-title":"Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene.","volume":"9","author":"RL Sjoberg","year":"2006","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsycho.2009.12.010","article-title":"Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults.","volume":"83","author":"D Armbruster","year":"2010","journal-title":"Biol Psychol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1471-4159.2009.06462.x","article-title":"Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences.","volume":"112","author":"DB Goswami","year":"2010","journal-title":"J Neurochem"},{"key":"ref14","first-page":"252","article-title":"The therapeutic role of 5-HT1A and 5-HT2A receptors in depression.","volume":"29","author":"P Celada","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.nucmedbio.2007.06.008","article-title":"Serotonin-1A receptor imaging in recurrent depression: replication and literature review.","volume":"34","author":"WC Drevets","year":"2007","journal-title":"Nucl Med Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00213-002-1379-5","article-title":"5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study.","volume":"167","author":"C Messa","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archpsyc.57.2.174","article-title":"Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.","volume":"57","author":"PA Sargent","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1523\/JNEUROSCI.18-18-07394.1998","article-title":"Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity.","volume":"18","author":"CA Stockmeier","year":"1998","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1001\/archpsyc.57.9.850","article-title":"Brain serotonin2 receptors in major depression: a positron emission tomography study.","volume":"57","author":"LN Yatham","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1017\/S1461145708009012","article-title":"Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder.","volume":"12","author":"B Szewczyk","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.1471-4159.2007.05201.x","article-title":"Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline.","volume":"105","author":"DV Rossi","year":"2008","journal-title":"J Neurochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1073\/pnas.1034823100","article-title":"Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression.","volume":"100","author":"M El Yacoubi","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/1025389031000111311","article-title":"Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models.","volume":"6","author":"DH Overstreet","year":"2003","journal-title":"Stress"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuron.2009.12.003","article-title":"5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants.","volume":"65","author":"JW Richardson-Jones","year":"2010","journal-title":"Neuron"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1034\/j.1601-183X.2002.10305.x","article-title":"Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge.","volume":"1","author":"MM van Gaalen","year":"2002","journal-title":"Genes Brain Behav"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1471-4159.2005.03169.x","article-title":"Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington&apos;s disease mutation.","volume":"94","author":"A Bauer","year":"2005","journal-title":"J Neurochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/hmg\/ddn385","article-title":"Altered serotonin receptor expression is associated with depression-related behavior in the R6\/1 transgenic mouse model of Huntington&apos;s disease.","volume":"18","author":"TY Pang","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1046\/j.1471-4159.2002.01084.x","article-title":"Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington&apos;s disease.","volume":"82","author":"IG Yohrling","year":"2002","journal-title":"J Neurochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/brain\/awp006","article-title":"Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.","volume":"132","author":"MA Pouladi","year":"2009","journal-title":"Brain"},{"key":"ref30","article-title":"Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington&apos;s disease mice.","author":"MS Zajac","year":"2009","journal-title":"Hippocampus"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.nbd.2007.11.006","article-title":"Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington&apos;s disease transgenic mice.","volume":"29","author":"J Nithianantharajah","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington&apos;s disease transgenic mice.","volume":"141","author":"TY Pang","year":"2006","journal-title":"Neuroscience"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/026988110201600201","article-title":"Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine.","volume":"16","author":"A Harkin","year":"2002","journal-title":"J Psychopharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2005.03.017","article-title":"Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test.","volume":"29","author":"SC Dulawa","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1476-5381.1991.tb12342.x","article-title":"Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia.","volume":"103","author":"DJ Bill","year":"1991","journal-title":"Br J Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbr.2005.09.020","article-title":"Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT.","volume":"167","author":"B Bert","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2004.01.031","article-title":"8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents.","volume":"487","author":"PB Hedlund","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0091-3057(01)00599-8","article-title":"Intra- and interstrain differences in models of \u201cbehavioral despair\u201d.","volume":"70","author":"F Bai","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1017\/S1461145708009048","article-title":"Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice.","volume":"11","author":"T Renoir","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref40","article-title":"Sex Differences in Animal Models of Depression and Antidepressant Response.","author":"C Dalla","year":"2009","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/npp.2008.217","article-title":"TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes.","volume":"34","author":"Y Sun","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1093\/hmg\/ddn159","article-title":"Sex differences in a transgenic rat model of Huntington&apos;s disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males.","volume":"17","author":"FJ Bode","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbr.2006.12.004","article-title":"Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington&apos;s disease.","volume":"178","author":"JL Dorner","year":"2007","journal-title":"Behav Brain Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e9077","DOI":"10.1371\/journal.pone.0009077","article-title":"Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington&apos;s disease.","volume":"5","author":"NI Wood","year":"2010","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1176\/appi.ajp.157.9.1445","article-title":"Gender differences in treatment response to sertraline versus imipramine in chronic depression.","volume":"157","author":"SG Kornstein","year":"2000","journal-title":"Am J Psychiatry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s002130100836","article-title":"Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?","volume":"159","author":"CE Renard","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"ref47","first-page":"493","article-title":"Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats.","volume":"58","author":"Z Rogoz","year":"2006","journal-title":"Pharmacol Rep"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2010.01.022","article-title":"The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior.","volume":"209","author":"G Sarkisyan","year":"2010","journal-title":"Behav Brain Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/026988110201600205","article-title":"Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex.","volume":"16","author":"LA Dawson","year":"2002","journal-title":"J Psychopharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1046\/j.1460-9568.2003.02960.x","article-title":"Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter.","volume":"18","author":"S Bouali","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1523\/JNEUROSCI.20-21-07888.2000","article-title":"Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences.","volume":"20","author":"Q Li","year":"2000","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-2999(92)90317-W","article-title":"Sex difference for tolerance of 5-HT1A receptor-mediated temperature and corticosterone responses in mice.","volume":"219","author":"Y Nakano","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1046\/j.1471-4159.1999.721773.x","article-title":"Brain neurotransmitter deficits in mice transgenic for the Huntington&apos;s disease mutation.","volume":"72","author":"GP Reynolds","year":"1999","journal-title":"J Neurochem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1020262205227","article-title":"Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists.","volume":"32","author":"DH Overstreet","year":"2002","journal-title":"Behav Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0006-3223(03)00696-6","article-title":"Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice.","volume":"54","author":"A Lira","year":"2003","journal-title":"Biol Psychiatry"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuroscience.2007.12.032","article-title":"A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders.","volume":"152","author":"JD Olivier","year":"2008","journal-title":"Neuroscience"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0006-8993(97)00119-4","article-title":"Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression.","volume":"756","author":"GG Kinney","year":"1997","journal-title":"Brain Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.neuroimage.2008.05.009","article-title":"Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study.","volume":"42","author":"BN Frey","year":"2008","journal-title":"Neuroimage"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1038\/npp.2009.54","article-title":"Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality.","volume":"34","author":"JM Miller","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.mp.4001401","article-title":"Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.","volume":"9","author":"Z Bhagwagar","year":"2004","journal-title":"Mol Psychiatry"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1358\/dnp.2007.20.10.1181354","article-title":"5-HT7 receptor antagonists as a new class of antidepressants.","volume":"20","author":"O Mnie-Filali","year":"2007","journal-title":"Drug News Perspect"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pscychresns.2010.05.005","article-title":"Gender differences in alpha-[(11)C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: a positron emission tomography study.","volume":"183","author":"BN Frey","year":"2010","journal-title":"Psychiatry Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0169-328X(03)00337-1","article-title":"Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance.","volume":"118","author":"P Preece","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1073\/pnas.94.10.5308","article-title":"Differences between males and females in rates of serotonin synthesis in human brain.","volume":"94","author":"S Nishizawa","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.psyneuen.2009.03.014","article-title":"Sex differences in hormonal responses to a social stressor in chronic major depression.","volume":"34","author":"KK Chopra","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/hmg\/ddl094","article-title":"Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6\/2 transgenic mouse model of Huntington&apos;s disease.","volume":"15","author":"M Bjorkqvist","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainresbull.2007.12.007","article-title":"Increased thirst and drinking in Huntington&apos;s disease and the R6\/2 mouse.","volume":"76","author":"NI Wood","year":"2008","journal-title":"Brain Res Bull"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1111\/j.1471-4159.2007.04961.x","article-title":"CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A\/C receptors.","volume":"103","author":"S Mato","year":"2007","journal-title":"J Neurochem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00213-003-1498-7","article-title":"Long-lasting effects of chronic stress on DOI-induced hyperthermia in male rats.","volume":"169","author":"L Matuszewich","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuropharm.2007.12.001","article-title":"Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.","volume":"54","author":"KA Jennings","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0022133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:12:45Z","timestamp":1589019165000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0022133"}},"subtitle":[],"editor":[{"given":"Kenji","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,8]]},"references-count":71,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0022133","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,8]]}}}