{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:49:56Z","timestamp":1791078596009,"version":"4.1.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0022231","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T17:01:19Z","timestamp":1310662879000},"page":"e22231","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation"],"prefix":"10.1371","volume":"6","author":[{"given":"Tamara","family":"Seredenina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgun","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Luthi-Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington&apos;s disease chromosomes.","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.","volume":"90","author":"SW Davies","year":"1997","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.","volume":"277","author":"M DiFiglia","year":"1997","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pneurobio.2006.11.004","article-title":"Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington&apos;s disease.","volume":"83","author":"R Truant","year":"2007","journal-title":"Prog Neurobiol Nov;"},{"key":"ref5","first-page":"111","article-title":"Huntington\u2019s and other polyglutamine diseases: many effects of single gene mutations.","author":"R Luthi-Carter","year":"2007"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain.","volume":"11","author":"R Luthi-Carter","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","article-title":"Decreased expression of striatal signaling genes in a mouse model of Huntington&apos;s disease.","volume":"9","author":"R Luthi-Carter","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1471-4159.2005.03588.x","article-title":"Selective deficits in the expression of striatal-enriched mRNAs in Huntington&apos;s disease.","volume":"96","author":"PA Desplats","year":"2006","journal-title":"J Neurochem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","article-title":"Mutant huntingtin&apos;s effects on striatal gene expression in mice recapitulate changes observed in human Huntington&apos;s disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.","volume":"16","author":"A Kuhn","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington&apos;s disease brain.","volume":"15","author":"A Hodges","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1566-2772(03)00059-8","article-title":"Mechanisms of transcriptional dysregulation in Huntington&apos;s disease.","volume":"3","author":"R Luthi-Carter","year":"2003","journal-title":"Clinical neuroscience research"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","article-title":"Transcriptional abnormalities in Huntington disease.","volume":"19","author":"KL Sugars","year":"2003","journal-title":"Trends Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1093\/hmg\/ddq055","article-title":"CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington&apos;s disease.","volume":"19","author":"JR Crittenden","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1523\/JNEUROSCI.23-28-09418.2003","article-title":"Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington&apos;s disease mice.","volume":"23","author":"RJ Ferrante","year":"2003","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"15564","DOI":"10.1073\/pnas.0804249105","article-title":"The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington&apos;s disease transgenic mice.","volume":"105","author":"EA Thomas","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/hmg\/ddm064","article-title":"Modulation of nucleosome dynamics in Huntington&apos;s disease.","volume":"16","author":"EC Stack","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"34253","DOI":"10.1074\/jbc.274.48.34253","article-title":"G protein selectivity is a determinant of RGS2 function.","volume":"274","author":"SP Heximer","year":"1999","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.1523\/JNEUROSCI.18-18-07178.1998","article-title":"Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.","volume":"18","author":"T Ingi","year":"1998","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2006.07.012","article-title":"RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi\/o-mediated inhibition of presynaptic Ca2+ channels.","volume":"51","author":"J Han","year":"2006","journal-title":"Neuron"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"15842","DOI":"10.1074\/jbc.M210663200","article-title":"Identification of RGS2 and type V adenylyl cyclase interaction sites.","volume":"278","author":"S Salim","year":"2003","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/35059104","article-title":"RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.","volume":"409","author":"S Sinnarajah","year":"2001","journal-title":"Nature"},{"key":"ref22","first-page":"899","article-title":"RGS protein specificity towards Gq- and Gi\/o-mediated ERK 1\/2 and Akt activation, in vitro.","volume":"40","author":"T Anger","year":"2007","journal-title":"J Biochem Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1523\/JNEUROSCI.3044-08.2008","article-title":"Dysregulation of gene expression in primary neuron models of Huntington&apos;s disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.","volume":"28","author":"H Runne","year":"2008","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0301-0082(94)90037-X","article-title":"Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum.","volume":"44","author":"R Kotter","year":"1994","journal-title":"Prog Neurobiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1523\/JNEUROSCI.20-15-05630.2000","article-title":"The Dopamine\/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway.","volume":"20","author":"S Paul","year":"2000","journal-title":"J Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nn989","article-title":"NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling.","volume":"6","author":"S Paul","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-beta.","volume":"8","author":"EM Snyder","year":"2005","journal-title":"Nat Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(01)00140-1","article-title":"Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum.","volume":"94","author":"P Vargiu","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1242\/jcs.01660","article-title":"The Ras superfamily at a glance.","volume":"118","author":"K Wennerberg","year":"2005","journal-title":"J Cell Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1128\/MCB.24.13.5788-5796.2004","article-title":"Rhes is involved in striatal function.","volume":"24","author":"D Spano","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2007.10.007","article-title":"The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons.","volume":"37","author":"F Errico","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1073\/pnas.120166397","article-title":"Severe deficiencies in dopamine signaling in presymptomatic Huntington&apos;s disease mice.","volume":"97","author":"JA Bibb","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0169-328X(02)00216-4","article-title":"Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington&apos;s disease.","volume":"102","author":"BS Spektor","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"21248","DOI":"10.1074\/jbc.M312407200","article-title":"RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq\/11alpha signaling.","volume":"279","author":"LS Bernstein","year":"2004","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1006\/bbrc.1994.1836","article-title":"Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in neonatal mammalian brain.","volume":"201","author":"R Joseph","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-3806(02)00348-6","article-title":"The fetal and neonatal brain protein neuronatin protects PC12 cells against certain types of toxic insult.","volume":"136","author":"S Zheng","year":"2002","journal-title":"Brain Res Dev Brain Res"},{"key":"ref37","article-title":"Diminished hippocalcin expression in huntington&apos;s disease (HD) brain does not account for increased striatal neuron vulnerability as assessed in primary neuron models of HD","author":"N Rudinskiy","year":"2009"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1126\/science.1172871","article-title":"Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.","volume":"324","author":"S Subramaniam","year":"2009","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nature09564","article-title":"CRTC3 links catecholamine signalling to energy balance.","volume":"468","author":"Y Song","year":"2010","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.1056784","article-title":"Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.","volume":"291","author":"FC Nucifora Jr","year":"2001","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1074\/jbc.M310226200","article-title":"Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington&apos;s disease that contributes to polyglutamine pathogenesis.","volume":"279","author":"KL Sugars","year":"2004","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/hmg\/ddi443","article-title":"Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1\/2 protects against mutant huntingtin-associated toxicity.","volume":"15","author":"BL Apostol","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/hmg\/ddq460","article-title":"ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington&apos;s disease.","volume":"20","author":"P Maher","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/hmg\/10.17.1829","article-title":"Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington&apos;s disease.","volume":"10","author":"A Wyttenbach","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jnr.10272","article-title":"Striatal neurochemical changes in transgenic models of Huntington&apos;s disease.","volume":"68","author":"MA Ariano","year":"2002","journal-title":"J Neurosci Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/hmg\/ddg046","article-title":"Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington&apos;s disease knock-in mice.","volume":"12","author":"S Gines","year":"2003","journal-title":"Human Molecular Genetics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1523\/JNEUROSCI.3493-03.2004","article-title":"CRE-mediated transcription is increased in Huntington&apos;s disease transgenic mice.","volume":"24","author":"K Obrietan","year":"2004","journal-title":"J Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1111\/j.1432-1033.2004.04133.x","article-title":"Role of extracellular signal regulated kinases 1 and 2 in neuronal survival.","volume":"271","author":"M Hetman","year":"2004","journal-title":"Eur J Biochem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1111\/j.1432-1033.2004.04132.x","article-title":"Oxidative neuronal injury. The dark side of ERK1\/2.","volume":"271","author":"CT Chu","year":"2004","journal-title":"Eur J Biochem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1006\/mcne.2002.1152","article-title":"Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6\/2 Huntington&apos;s disease transgenic mice.","volume":"20","author":"JC Lievens","year":"2002","journal-title":"Mol Cell Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1096\/fj.07-9814","article-title":"Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.","volume":"22","author":"E Roze","year":"2008","journal-title":"FASEB J"},{"key":"ref52","first-page":"495","article-title":"RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival.","volume":"15","author":"M Inoue-Mochita","year":"2009","journal-title":"Mol Vis"},{"key":"ref53","first-page":"1259","article-title":"Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.","volume":"111","author":"SP Heximer","year":"2003","journal-title":"J Clin Invest"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/hmg\/ddi014","article-title":"Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington&apos;s disease: neuronal selectivity and potential neuroprotective role of HAP1.","volume":"14","author":"B Zucker","year":"2005","journal-title":"Hum Mol Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0022231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T20:21:24Z","timestamp":1560370884000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0022231"}},"subtitle":[],"editor":[{"given":"Xiao-Jiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0022231","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13393988.14762099","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}