{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:15:12Z","timestamp":1781795712471,"version":"3.54.5"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0022246","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T21:02:21Z","timestamp":1310677341000},"page":"e22246","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Osmosensitivity of Transient Receptor Potential Vanilloid 1 Is Synergistically Enhanced by Distinct Activating Stimuli Such as Temperature and Protons"],"prefix":"10.1371","volume":"6","author":[{"given":"Eri","family":"Nishihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi Y.","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.ph.39.030177.001153","article-title":"Regulation of body fluids.","volume":"39","author":"B Andersson","year":"1977","journal-title":"Annu Rev Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1152\/physrev.1978.58.3.582","article-title":"Regulation of water intake.","volume":"58","author":"B Andersson","year":"1978","journal-title":"Physiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/bmj.307.6899.305","article-title":"Management of hyponatraemia.","volume":"307","author":"AI Arieff","year":"1993","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1113\/jphysiol.1996.sp021305","article-title":"Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits.","volume":"492","author":"JC Ayus","year":"1996","journal-title":"J Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1385\/NCC:6:1:67","article-title":"H<sub>2<\/sub>O coma.","volume":"6","author":"D Stiefel","year":"2007","journal-title":"Neurocritical Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2400","article-title":"Central mechanisms of osmosensation and systemic osmoregulation.","volume":"9","author":"CW Bourque","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nn1614","article-title":"An N-terminal variant of Trpv1 channel is required for osmosensor transduction.","volume":"9","author":"R Sharif Naeini","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9069","DOI":"10.1523\/JNEUROSCI.0877-06.2006","article-title":"Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality.","volume":"26","author":"S Ciura","year":"2006","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"R1285","DOI":"10.1152\/ajpregu.00003.2008","article-title":"Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia.","volume":"294","author":"AC Taylor","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","article-title":"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertevrate osmoreceptor.","volume":"103","author":"W Liedtke","year":"2000","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35036318","article-title":"OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.","volume":"2","author":"R Strotmann","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(00)02212-2","article-title":"Trp12, a novel Trp related protein form kidney.","volume":"485","author":"U Wissenbach","year":"2000","journal-title":"FEBS Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13698","DOI":"10.1073\/pnas.1735416100","article-title":"Abnormal osmotic regulation in <italic>trpv4<sup>-\/-<\/sup><\/italic> mice.","volume":"100","author":"W Liedtke","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"C96","DOI":"10.1152\/ajpcell.00559.2002","article-title":"Impaired osmotic sensation in mice lacking TRPV4.","volume":"285","author":"A Mizuno","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway.","volume":"389","author":"MJ Caterina","year":"1997","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/S0021-9258(18)52309-7","article-title":"Effect of temperature on receptor-activated changes in [Ca<sup>2+<\/sup>]<italic><sub>i<\/sub><\/italic> and their determination using fluorescent probes.","volume":"266","author":"TJ Shuttleworth","year":"1991","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.68.1.425","article-title":"Cellular and molecular biology of the aquaporin water channels.","volume":"68","author":"M Borgnia","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1073\/pnas.91.14.6269","article-title":"Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the vasolateral membrane of kidney collecting duct cells.","volume":"91","author":"K Ishibashi","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.91.26.13052","article-title":"Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance.","volume":"91","author":"JS Jung","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physrev.00024.2001","article-title":"Aquaporins in the kidney: from molecules to medicine.","volume":"82","author":"S Nielsen","year":"2002","journal-title":"Physiol Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","article-title":"The cloned capsaicin receptor integrates multiple pain-producing stimuli.","volume":"21","author":"M Tominaga","year":"1998","journal-title":"Neuron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15485","DOI":"10.1074\/jbc.M600549200","article-title":"A role for AQP5 in activation of TRPV4 by hypotonicity.","volume":"281","author":"X Liu","year":"2006","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1074\/jbc.274.10.6330","article-title":"Cloning of a stretch-inhibitable nonselective cation channel.","volume":"274","author":"M Suzuki","year":"1999","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/geno.2001.6582","article-title":"The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants.","volume":"76","author":"Q Xue","year":"2001","journal-title":"Genomics"},{"key":"ref25","first-page":"2000","article-title":"Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons.","volume":"97","author":"L Liu","year":"2007","journal-title":"J Neurophysiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0014-2999(01)01123-2","article-title":"Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide.","volume":"423","author":"J Sprague","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0896-6273(00)80034-3","article-title":"Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons.","volume":"16","author":"SHR Oliet","year":"1996","journal-title":"Neuron"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/j.1460-9568.2006.04670.x","article-title":"Calcium permeability and flux through osmosensory transduction channels of isolated rat supraoptic nucleus neurons.","volume":"23","author":"Z Zhang","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ecl.2006.09.006","article-title":"Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state.","volume":"35","author":"AE Kitabchi","year":"2006","journal-title":"Endocrinol Metab Clin N Am"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/path.1700720203","article-title":"The mediation of altered capillary permeability in acute inflammation.","volume":"72","author":"WG Spector","year":"1956","journal-title":"J Pathol Bacteriol"},{"key":"ref31","first-page":"227","article-title":"Chemical and osmolar changes of interstitial fluid in acute inflammatory states.","volume":"21","author":"C Vakili","year":"1970","journal-title":"Surg Forum"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0006-8993(00)02138-7","article-title":"The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in fogs.","volume":"862","author":"DT Hamamoto","year":"2000","journal-title":"Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1523\/JNEUROSCI.22-15-06408.2002","article-title":"Heat-evoked activation of the ion channel, TRPV4.","volume":"22","author":"AD G\u00fcler","year":"2002","journal-title":"J Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0022246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T02:19:15Z","timestamp":1638065955000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0022246"}},"subtitle":[],"editor":[{"given":"Steven","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0022246","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}