{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:02:17Z","timestamp":1791291737450,"version":"4.1.0"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T00:00:00Z","timestamp":1311292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0022391","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T18:59:25Z","timestamp":1311361165000},"page":"e22391","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":72,"title":["Comparative Analysis of mRNA Isoform Expression in Cardiac Hypertrophy and Development Reveals Multiple Post-Transcriptional Regulatory Modules"],"prefix":"10.1371","volume":"6","author":[{"given":"Ji Yeon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Vatner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sadoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nm0504-467","article-title":"A decade of discoveries in cardiac biology.","volume":"10","author":"EN Olson","year":"2004","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1172\/JCI28884","article-title":"Cardiac hypertrophy: stressing out the heart.","volume":"116","author":"JC Tardiff","year":"2006","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity.","volume":"358","author":"JA Hill","year":"2008","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1152\/physiolgenomics.00318.2005","article-title":"Transcriptional alterations in the left ventricle of three hypertensive rat models.","volume":"27","author":"C Cerutti","year":"2006","journal-title":"Physiol Genomics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/CIRCGENETICS.108.806935","article-title":"Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy.","volume":"2","author":"SP Sheehy","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physiolgenomics.00040.2004","article-title":"Microarray analysis of gene expression after transverse aortic constriction in mice.","volume":"19","author":"M Zhao","year":"2004","journal-title":"Physiol Genomics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10741-007-9034-1","article-title":"Return to the fetal gene program protects the stressed heart: a strong hypothesis.","volume":"12","author":"M Rajabi","year":"2007","journal-title":"Heart Fail Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.biocel.2008.02.020","article-title":"Molecular regulation of cardiac hypertrophy.","volume":"40","author":"SP Barry","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcdb.2006.11.012","article-title":"Re-employment of developmental transcription factors in adult heart disease.","volume":"18","author":"T Oka","year":"2007","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.RES.0000072977.86706.23","article-title":"Roles of cardiac transcription factors in cardiac hypertrophy.","volume":"92","author":"H Akazawa","year":"2003","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy.","volume":"13","author":"A Care","year":"2007","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","article-title":"MicroRNAs play an essential role in the development of cardiac hypertrophy.","volume":"100","author":"D Sayed","year":"2007","journal-title":"Circ Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA.","volume":"316","author":"E van Rooij","year":"2007","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function.","volume":"116","author":"DP Bartel","year":"2004","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels.","volume":"466","author":"H Guo","year":"2010","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.108.192872","article-title":"MicroRNA regulation of cardiovascular development.","volume":"104","author":"KR Cordes","year":"2009","journal-title":"Circ Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/CIRCRESAHA.109.200451","article-title":"Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.","volume":"105","author":"PK Rao","year":"2009","journal-title":"Circ Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCULATIONAHA.109.889048","article-title":"MicroRNAs add a new dimension to cardiovascular disease.","volume":"121","author":"EM Small","year":"2010","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/CIRCULATIONAHA.108.813576","article-title":"Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support.","volume":"119","author":"SJ Matkovich","year":"2009","journal-title":"Circulation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes.","volume":"456","author":"ET Wang","year":"2008","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing.","volume":"40","author":"Q Pan","year":"2008","journal-title":"Nat Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/cvr\/cvq023","article-title":"Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy.","volume":"86","author":"T Yamazaki","year":"2010","journal-title":"Cardiovasc Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cardiores.2005.06.024","article-title":"Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles.","volume":"68","author":"P Liao","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.RES.0000115522.52554.86","article-title":"Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium.","volume":"94","author":"S Lahmers","year":"2004","journal-title":"Circ Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"20333","DOI":"10.1073\/pnas.0809045105","article-title":"A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.","volume":"105","author":"A Kalsotra","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e1000553","DOI":"10.1371\/journal.pcbi.1000553","article-title":"Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors.","volume":"5","author":"N Salomonis","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCGENETICS.109.904698","article-title":"Heart failure-associated changes in RNA splicing of sarcomere genes.","volume":"3","author":"SW Kong","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/sj.emboj.7600054","article-title":"Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.","volume":"23","author":"JH Ding","year":"2004","journal-title":"Embo J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2004.11.036","article-title":"ASF\/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.","volume":"120","author":"X Xu","year":"2005","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1128\/MCB.25.14.6267-6278.2005","article-title":"Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy.","volume":"25","author":"AN Ladd","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.devcel.2009.02.009","article-title":"SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart.","volume":"16","author":"Y Feng","year":"2009","journal-title":"Developmental Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/nar\/gki158","article-title":"A large-scale analysis of mRNA polyadenylation of human and mouse genes.","volume":"33","author":"B Tian","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2005-6-12-r100","article-title":"Biased alternative polyadenylation in human tissues.","volume":"6","author":"H Zhang","year":"2005","journal-title":"Genome Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1073\/pnas.0900028106","article-title":"Progressive lengthening of 3\u2032 untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development.","volume":"106","author":"Z Ji","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1155390","article-title":"Proliferating cells express mRNAs with shortened 3\u2032 untranslated regions and fewer microRNA target sites.","volume":"320","author":"R Sandberg","year":"2008","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2009.06.016","article-title":"Widespread shortening of 3\u2032UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells.","volume":"138","author":"C Mayr","year":"2009","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e8419","DOI":"10.1371\/journal.pone.0008419","article-title":"Reprogramming of 3\u2032 untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types.","volume":"4","author":"Z Ji","year":"2009","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"192 e191","DOI":"10.1016\/j.cell.2008.03.010","article-title":"SnapShot: The splicing regulatory machinery.","volume":"133","author":"M Gabut","year":"2008","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1097-2765(03)00270-3","article-title":"Pre-mRNA splicing: awash in a sea of proteins.","volume":"12","author":"MS Jurica","year":"2003","journal-title":"Mol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00018-009-0120-5","article-title":"Fox-1 family of RNA-binding proteins.","volume":"66","author":"H Kuroyanagi","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1074\/jbc.M901026200","article-title":"Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A\/C)-rich regions in pre-mRNA.","volume":"284","author":"B Heinrich","year":"2009","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.molcel.2009.12.003","article-title":"Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.","volume":"36","author":"Y Xue","year":"2009","journal-title":"Mol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1128\/MCB.25.22.10005-10016.2005","article-title":"Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.","volume":"25","author":"JG Underwood","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/emboj\/cdg089","article-title":"A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.","volume":"22","author":"Y Jin","year":"2003","journal-title":"Embo Journal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nsmb.1545","article-title":"An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells.","volume":"16","author":"GW Yeo","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1182\/blood-2007-01-068940","article-title":"Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.","volume":"111","author":"G Yang","year":"2008","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"H2071","DOI":"10.1152\/ajpheart.01156.2009","article-title":"Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.","volume":"298","author":"X Wu","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cardiores.2005.12.015","article-title":"Integrin signalling: the tug-of-war in heart hypertrophy.","volume":"70","author":"M Brancaccio","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1101\/gad.1837009","article-title":"An inducible change in Fox-1\/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons.","volume":"23","author":"JA Lee","year":"2009","journal-title":"Genes Dev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/BST0350919","article-title":"Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility.","volume":"35","author":"EE Strehler","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"30070","DOI":"10.1074\/jbc.M706273200","article-title":"T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs.","volume":"282","author":"S Yamasaki","year":"2007","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.biochi.2005.10.011","article-title":"Mammalian CELF\/Bruno-like RNA-binding proteins: molecular characteristics and biological functions.","volume":"88","author":"C Barreau","year":"2006","journal-title":"Biochimie"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrm2780","article-title":"Building ubiquitin chains: E2 enzymes at work.","volume":"10","author":"Y Ye","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nrm1988","article-title":"The anaphase promoting complex\/cyclosome: a machine designed to destroy.","volume":"7","author":"JM Peters","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/ncb1109-1275","article-title":"Cyclin-dependent kinases: a family portrait.","volume":"11","author":"M Malumbres","year":"2009","journal-title":"Nat Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs.","volume":"19","author":"RC Friedman","year":"2009","journal-title":"Genome Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1440-1681.2002.03655.x","article-title":"Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart.","volume":"29","author":"JJ Lehman","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.yjmcc.2009.08.024","article-title":"The extracellular matrix: at the center of it all.","volume":"48","author":"SL Bowers","year":"2010","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1152\/physrev.00032.2006","article-title":"Cardiac myocyte cell cycle control in development, disease, and regeneration.","volume":"87","author":"P Ahuja","year":"2007","journal-title":"Physiol Rev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","article-title":"Return to the fetal gene program: a suggested metabolic link to gene expression in the heart.","volume":"1188","author":"H Taegtmeyer","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1093\/nar\/gkp508","article-title":"Overestimation of alternative splicing caused by variable probe characteristics in exon arrays.","volume":"37","author":"D Gaidatzis","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nsmb1155","article-title":"RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.","volume":"13","author":"M de la Mata","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nsmb1030","article-title":"The human SWI\/SNF subunit Brm is a regulator of alternative splicing.","volume":"13","author":"E Batsche","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm778","article-title":"Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.","volume":"8","author":"M Sano","year":"2002","journal-title":"Nat Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1093\/nar\/gkm485","article-title":"A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing.","volume":"35","author":"D Das","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/emboj\/cdg089","article-title":"A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.","volume":"22","author":"Y Jin","year":"2003","journal-title":"Embo J"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/cb800138w","article-title":"Alternative polyadenylation: a twist on mRNA 3\u2032 end formation.","volume":"3","author":"CS Lutz","year":"2008","journal-title":"ACS Chem Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.yexcr.2010.02.040","article-title":"Heterogeneity in mammalian RNA 3\u2032 end formation.","volume":"316","author":"JR Neilson","year":"2010","journal-title":"Exp Cell Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/nar\/gkp1176","article-title":"Molecular mechanisms of eukaryotic pre-mRNA 3\u2032 end processing regulation.","volume":"38","author":"S Millevoi","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0092-8674(00)82000-0","article-title":"The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation.","volume":"87","author":"Y Takagaki","year":"1996","journal-title":"Cell"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.107.160614","article-title":"Inhibition of glycogen synthase kinase 3beta during heart failure is protective.","volume":"101","author":"S Hirotani","year":"2007","journal-title":"Circ Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkl870","article-title":"PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes.","volume":"35","author":"JY Lee","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1101\/gad.1703108","article-title":"Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2.","volume":"22","author":"C Zhang","year":"2008","journal-title":"Genes Dev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0022391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:12:45Z","timestamp":1589029965000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0022391"}},"subtitle":[],"editor":[{"given":"Gangjian","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,22]]},"references-count":74,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0022391","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,22]]}}}