{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:32:27Z","timestamp":1789021947681,"version":"build-2803163510"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T00:00:00Z","timestamp":1313971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0022447","type":"journal-article","created":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T19:15:28Z","timestamp":1314040528000},"page":"e22447","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":57,"title":["Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI"],"prefix":"10.1371","volume":"6","author":[{"given":"Efrat","family":"Eliyahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Wolfson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward H.","family":"Schuchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogera M.","family":"Simonaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,8,22]]},"reference":[{"key":"ref1","first-page":"3421","article-title":"The Mucopolysaccharidoses.","author":"EF Neufeld","year":"2001"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1017\/S1462399408000550","article-title":"The mucopolysaccharidoses: a success of molecular medicine.","volume":"10","author":"LA Clarke","year":"2008","journal-title":"Expert Rev Mol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00431-007-0635-4","article-title":"Mucopolysaccharidosis type II (Hunter syndrome): a clinical review and recommendations for treatment in the era of enzyme replacement therapy.","volume":"167","author":"JE Wraith","year":"2008","journal-title":"Eur J Pediatr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/01913121003648485","article-title":"Ultrastructural analysis of dermal fibroblasts in mucopolysaccharidosis type I: Effects of enzyme replacement therapy and hematopoietic cell transplantation.","volume":"34","author":"J Cox-Brinkman","year":"2010","journal-title":"Ultrastruct Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/glycob\/cwq088","article-title":"Effect of 6 years of enzyme replacement therapy on plasma and urine glycosaminoglycans in attenuated MPS I patients.","volume":"20","author":"GV Coppa","year":"2010","journal-title":"Glycobiology"},{"key":"ref6","article-title":"Treatment of mucopolysaccharidosis type II (Hunter syndrome) with idursulfase: the relevance of clinical trial end points.","author":"E Glamuzina","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"ref7","first-page":"89","article-title":"Enzyme replacement therapy for mucopolysaccharidosis VI: Growth and pubertal development in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase.","volume":"3","author":"C Decker","year":"2010","journal-title":"J Pediatr Rehabil Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1172-5-5","article-title":"Mucopolysaccharidosis VI.","volume":"12","author":"V Valayannopoulos","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1399-0004.2009.01324.x","article-title":"Enzyme replacement therapy for mucopolysaccharidosis VI from 8 weeks of age\u2013a sibling control study.","volume":"77","author":"JJ McGill","year":"2010","journal-title":"Clin Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/hum.2009.189","article-title":"Different serum enzyme levels are required to rescue the various systemic features of the mucopolysaccharidoses.","volume":"21","author":"G Cotugno","year":"2010","journal-title":"Hum Gene Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ymgme.2008.07.003","article-title":"Radiographic evaluation of bones and joints in mucopolysaccharidosis I and VII dogs after neonatal gene therapy.","volume":"95","author":"RS Herati","year":"2008","journal-title":"Mol Genet Metab"},{"key":"ref12","article-title":"Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein.","author":"JZ Lu","year":"2011","journal-title":"Biotechnol Bioeng"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mt.2010.249","article-title":"Minicircle DNA-based Gene Therapy Coupled With Immune Modulation Permits Long-term Expression of \u03b1-L-Iduronidase in Mice With Mucopolysaccharidosis Type I.","volume":"19","author":"MJ Osborn","year":"2011","journal-title":"Mol Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1097\/00007890-199705270-00003","article-title":"Bone marrow transplantation in newborn rats with mucopolysaccharidosis type VI: biochemical, pathological, and clinical findings.","volume":"63","author":"CM Simonaro","year":"1997","journal-title":"Transplantation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/labinvest.3780345","article-title":"Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses.","volume":"81","author":"CM Simonaro","year":"2001","journal-title":"Lab Investi"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1203\/01.PDR.0000156510.96253.5A","article-title":"Joint and bone disease in mucopolysaccharidosis VI and VII: Identification of new therapeutic targets and biomarkers using animal models.","volume":"57","author":"CM Simonaro","year":"2005","journal-title":"Pediatr Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2353\/ajpath.2008.070564","article-title":"Mechanism of glycosaminoglycan-mediated bone &amp; joint disease: Implications for the mucopolysaccharidoses &amp; other connective tissue diseases.","volume":"172","author":"CM Simonaro","year":"2008","journal-title":"Amer J Path"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1073\/pnas.0912937107","article-title":"Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses.","volume":"107","author":"CM Simonaro","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/s10165-004-0275-8","article-title":"Efficacy and safety of the anti-TNF biologic agents.","volume":"14","author":"AL Weaver","year":"2004","journal-title":"Mod Rheumatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1172\/JCI116268","article-title":"Arylsulfatase B-deficient mucopolysaccharidosis in rats.","volume":"91","author":"M Yoshida","year":"1993","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1006\/geno.1995.9962","article-title":"Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation.","volume":"29","author":"T Kunieda","year":"1995","journal-title":"Genomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/hum.2009.189","article-title":"Different serum enzyme levels are required to rescue the various systemic features of the mucopolysaccharidoses.","volume":"21","author":"G Cotugno","year":"2010","journal-title":"Hum Gene Ther"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00005792-198807000-00002","article-title":"Respiratory complications of mucopolysaccharide storage disorders.","volume":"67","author":"GL Semenza","year":"1988","journal-title":"Medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbrc.2010.11.038","article-title":"Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death.","volume":"17","author":"KA Becker","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ymgme.2009.03.005","article-title":"Mechanism of shortened bones in mucopolysaccharidosis VII.","volume":"97","author":"JA Metcalf","year":"2009","journal-title":"Mol Genet Metab"},{"key":"ref26","first-page":"58","article-title":"Enzyme replacement therapy in mucopolysaccharidosis type I. Treatment of mucopolysaccharidosis type II (Hunter syndrome) with idursulfase: the relevance of clinical trial end points.","volume":"94","author":"E Miebach","year":"2005","journal-title":"Acta Paediatr Suppl"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ymgme.2007.04.009","article-title":"Long-term intra-articular administration of recombinant human N-acetylgalactosamine 4-sulfatase in feline mucopolysaccharidosis VI.","volume":"91","author":"D Auclair","year":"2007","journal-title":"Mol Gen Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/art.30136","article-title":"Body mass index and clinical response to infliximab in rheumatoid arthritis.","volume":"63","author":"R Klaasen","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta15100","article-title":"Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis: a systematic review and economic evaluation.","volume":"15","author":"M Rodgers","year":"2011","journal-title":"Health Technol Assess"},{"key":"ref30","article-title":"Infliximab Therapy Inhibits Inflammation-Induced Angiogenesis in the Mucosa of Patients With Crohn&apos;s Disease.","author":"S Rutella","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00296-009-1292-x","article-title":"Anti-TNF therapies: a comprehensive analysis of adverse effects associated with immunosuppression.","volume":"31","author":"V Connor","year":"2011","journal-title":"Rheumatol Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/archotol.130.2.233","article-title":"Airway management in mucopolysaccharide storage disorders.","volume":"130","author":"SY Shinhar","year":"2004","journal-title":"Arch Otolaryngol Head Neck Surg"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0022447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T07:20:54Z","timestamp":1560496854000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0022447"}},"subtitle":[],"editor":[{"given":"Markus M.","family":"Heimesaat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,8,22]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,8,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0022447","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,22]]}}}