{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:52:37Z","timestamp":1793170357225,"version":"4.5.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0022948","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T17:02:42Z","timestamp":1312218162000},"page":"e22948","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association between HLA Class I and Class II Alleles and the Outcome of West Nile Virus Infection: An Exploratory Study"],"prefix":"10.1371","volume":"6","author":[{"given":"Marion C.","family":"Lanteri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna","family":"Kaidarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Cate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Custer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Agapova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline P.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bielawny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Plummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie H.","family":"Tobler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Loeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0140-6736(01)05480-0","article-title":"Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey.","volume":"358","author":"F Mostashari","year":"2001","journal-title":"Lancet"},{"key":"ref2","article-title":"West Nile virus activity - Human disease cases reported 2005\u20132010.","author":"CfD Control","year":"2010"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.antiviral.2009.05.006","article-title":"Progress on the development of therapeutics against West Nile virus.","volume":"83","author":"MS Diamond","year":"2009","journal-title":"Antiviral Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.2741\/3432","article-title":"The host immunologic response to West Nile encephalitis virus.","volume":"14","author":"MS Diamond","year":"2009","journal-title":"Front Biosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.","volume":"10","author":"T Wang","year":"2004","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1128\/JVI.01122-06","article-title":"Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion.","volume":"80","author":"MA Samuel","year":"2006","journal-title":"J Virol"},{"key":"ref7","first-page":"3266","article-title":"Tregs control the development of symptomatic West Nile virus infection in humans and mice.","volume":"119","author":"MC Lanteri","year":"2009","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/j.1600-6143.2004.00592.x","article-title":"A seroprevalence study of west nile virus infection in solid organ transplant recipients.","volume":"4","author":"D Kumar","year":"2004","journal-title":"Am J Transplant"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3201\/eid1312.061265","article-title":"Risk factors forWest Nile virus neuroinvasive disease, California, 2005.","volume":"13","author":"CM Jean","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20051970","article-title":"CCR5 deficiency increases risk of symptomatic West Nile virus infection.","volume":"203","author":"WG Glass","year":"2006","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1128\/JVI.00489-06","article-title":"PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.","volume":"80","author":"MA Samuel","year":"2006","journal-title":"J Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1128\/JVI.80.6.2987-2999.2006","article-title":"RNase L plays a role in the antiviral response to West Nile virus.","volume":"80","author":"SV Scherbik","year":"2006","journal-title":"J Virol"},{"key":"ref13","article-title":"Cellular and molecular Immunology. 5th ed","year":"2005"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1046\/j.0960-7420.2001.00284.x","article-title":"The HLA Dictionary 2001: a summary of HLA-A, -B, -C, -DRB1\/3\/4\/5 and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR and -DQ antigens.","volume":"28","author":"GM Schreuder","year":"2001","journal-title":"Eur J Immunogenet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3324\/haematol.2010.030924","article-title":"The impact of human leucocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.","volume":"96","author":"C Bade-Doeding","year":"2010","journal-title":"Haematologica"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/CVI.00302-10","article-title":"HLA-A*3001 and A*3002 show distinct peptide binding patterns of the Mycobacterium tuberculosis protein TB10.4: consequences for immune recognition.","volume":"18","author":"R Axelsson-Robertson","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1399-0039.2010.01547.x","article-title":"Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters the POmega peptide motif.","volume":"76","author":"NE Elamin","year":"2010","journal-title":"Tissue Antigens"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2105-11-568","article-title":"Peptide binding predictions for HLA DR, DP and DQ molecules.","volume":"11","author":"P Wang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature08944","article-title":"The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.","volume":"464","author":"J Huang","year":"2010","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3201\/eid0505.990508","article-title":"Influence of host genetics on the severity of coccidioidomycosis.","volume":"5","author":"L Louie","year":"1999","journal-title":"Emerg Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/hep.21889","article-title":"Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection.","volume":"46","author":"P Hraber","year":"2007","journal-title":"Hepatology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ng.348","article-title":"A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.","volume":"41","author":"Y Kamatani","year":"2009","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/00002030-200406180-00006","article-title":"Maternal versus paternal inheritance of HLA class I alleles among HIV-infected children: consequences for clinical disease progression.","volume":"18","author":"L Kuhn","year":"2004","journal-title":"Aids"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/hep.21049","article-title":"Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.","volume":"43","author":"C Neumann-Haefelin","year":"2006","journal-title":"Hepatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/QAD.0b013e32831db247","article-title":"Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection.","volume":"23","author":"D van Manen","year":"2009","journal-title":"Aids"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013029","article-title":"Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population.","volume":"5","author":"R Appanna","year":"2010","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.actatropica.2009.07.025","article-title":"HLA class I and II polymorphisms in Mexican Mestizo patients with dengue fever.","volume":"112","author":"JA Falcon-Lezama","year":"2009","journal-title":"Acta Trop"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0198-8859(02)00682-1","article-title":"HLA-DR antigen frequencies in Mexican patients with dengue virus infection: HLA-DR4 as a possible genetic resistance factor for dengue hemorrhagic fever.","volume":"63","author":"C LaFleur","year":"2002","journal-title":"Hum Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.1371\/journal.pntd.0000304","article-title":"Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome.","volume":"2","author":"TP Nguyen","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1590\/S0074-02762004000600003","article-title":"Association of human leukocyte antigen DQ1 and dengue fever in a white Southern Brazilian population.","volume":"99","author":"JR Polizel","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.humimm.2007.03.001","article-title":"HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection.","volume":"68","author":"B Sierra","year":"2007","journal-title":"Hum Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1034\/j.1399-0039.2002.600405.x","article-title":"HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais.","volume":"60","author":"HA Stephens","year":"2002","journal-title":"Tissue Antigens"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.4049\/jimmunol.168.11.5959","article-title":"T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity.","volume":"168","author":"I Zivna","year":"2002","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0198-8859(01)00298-1","article-title":"Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations.","volume":"62","author":"K Cao","year":"2001","journal-title":"Hum Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e15343","DOI":"10.1371\/journal.pone.0015343","article-title":"Surface phenotype and functionality of WNV specific T cells differ with age and disease severity.","volume":"5","author":"P Piazza","year":"2010","journal-title":"PLoS One"},{"key":"ref36","article-title":"Anthropology: The dbMHC database for DNA and clinical data related to the human Major Histocompatibility Complex."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1749-6632.2001.tb02692.x","article-title":"The ecology of West Nile virus in South Africa and the occurrence of outbreaks in humans.","volume":"951","author":"PG Jupp","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"ref38","first-page":"42","article-title":"West nile virus: characteristics of an african virus adapting to the third millennium world.","volume":"4","author":"M Monini","year":"2010","journal-title":"Open Virol J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1365-3156.2004.01253.x","article-title":"Outbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002.","volume":"9","author":"E Depoortere","year":"2004","journal-title":"Trop Med Int Health"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3201\/eid0505.990506","article-title":"West Nile fever\u2013a reemerging mosquito-borne viral disease in Europe.","volume":"5","author":"Z Hubalek","year":"1999","journal-title":"Emerg Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.2807\/ese.14.31.19289-en","article-title":"West Nile virus infection in Veneto region, Italy, 2008\u20132009.","volume":"14","author":"L Barzon","year":"2009","journal-title":"Euro Surveill"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1749-6632.2001.tb02688.x","article-title":"Epidemic West Nile encephalitis in Romania: waiting for history to repeat itself.","volume":"951","author":"GL Campbell","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3201\/eid0701.010118","article-title":"Outbreak of West Nile virus infection, Volgograd Region, Russia, 1999.","volume":"7","author":"AE Platonov","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3201\/eid0704.017414","article-title":"Clinical characteristics of the West Nile fever outbreak, Israel, 2000.","volume":"7","author":"MY Chowers","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.med.57.121304.131418","article-title":"West Nile virus: epidemiology and clinical features of an emerging epidemic in the United States.","volume":"57","author":"EB Hayes","year":"2006","journal-title":"Annu Rev Med"},{"key":"ref46","first-page":"7","article-title":"U.S. diversity in more than Black and White.","volume":"27","author":"K Pollard","year":"1999","journal-title":"Popul Today"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/eji.200737196","article-title":"Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection.","volume":"37","author":"JD Brien","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1086\/586898","article-title":"Comprehensive analysis of west nile virus-specific T cell responses in humans.","volume":"197","author":"MC Lanteri","year":"2008","journal-title":"J Infect Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1128\/JVI.77.24.13323-13334.2003","article-title":"CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis.","volume":"77","author":"Y Wang","year":"2003","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.molmed.2009.04.001","article-title":"Multiple sclerosis - a response-to-damage model.","volume":"15","author":"BA t Hart","year":"2009","journal-title":"Trends Mol Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1590\/S0004-282X1996000300013","article-title":"[Genetic aspects in multiple sclerosis. II: HLA system].","volume":"54","author":"PA De Rezende","year":"1996","journal-title":"Arq Neuropsiquiatr"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jneuroim.2010.07.006","article-title":"Two HLA class I genes independently associated with multiple sclerosis.","volume":"226","author":"J Link","year":"2010","journal-title":"J Neuroimmunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1212\/WNL.0b013e3181ed9c9c","article-title":"HLA B*44: protective effects in MS susceptibility and MRI outcome measures.","volume":"75","author":"BC Healy","year":"2010","journal-title":"Neurology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1016\/j.vaccine.2007.07.062","article-title":"Using pCIN-mIL-4 DNA vector to express mRNA and protein and to improve herpes simplex virus-induced Behcet's disease symptoms in mice.","volume":"25","author":"SI Lee","year":"2007","journal-title":"Vaccine"},{"key":"ref55","first-page":"121","article-title":"[Serologic and molecular HLA typing in patients from Andalucia with Behcet's disease. Genetic and clinical correlations].","volume":"106","author":"MJ Castillo Palma","year":"1996","journal-title":"Med Clin (Barc)"},{"key":"ref56","first-page":"366","article-title":"[Type I herpes virus, HLA phenotype and Behcet disease].","volume":"98","author":"J Sanchez Roman","year":"1992","journal-title":"Med Clin (Barc)"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/CND.0b013e318209ef9a","article-title":"Posterior reversible encephalopathy syndrome resulting from guillain-barre-like syndrome secondary to west nile virus infection.","volume":"12","author":"A Abraham","year":"2011","journal-title":"J Clin Neuromuscul Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01376517-198302000-00007","article-title":"Guillain-Barre syndrome: disease process.","volume":"15","author":"M Prydun","year":"1983","journal-title":"J Neurosurg Nurs"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0165-5728(98)00072-1","article-title":"Guillain-Barre and Fisher's syndromes subsequent to Campylobacter jejuni enteritis are associated with HLA-B54 and Cw1 independent of anti-ganglioside antibodies.","volume":"88","author":"M Koga","year":"1998","journal-title":"J Neuroimmunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1212\/WNL.51.2.379","article-title":"HLA and T-cell receptor gene polymorphisms in Guillain-Barre syndrome.","volume":"51","author":"JJ Ma","year":"1998","journal-title":"Neurology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1086\/513786","article-title":"Differential distribution of HLA alleles in two forms of Guillain-Barre syndrome.","volume":"176","author":"DS Monos","year":"1997","journal-title":"J Infect Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1574-695X.2006.00058.x","article-title":"Dengue and dengue haemorrhagic fever: implications of host genetics.","volume":"47","author":"U Chaturvedi","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1537-2995.2008.01952.x","article-title":"Associations between WNV infection and symptoms reported by blood donors identified through nucleic acid test screening.","volume":"49","author":"B Custer","year":"2009","journal-title":"Transfusion"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0198-8859(01)00339-1","article-title":"Two-step high resolution sequence-based HLA-DRB typing of exon 2 DNA with taxonomy-based sequence analysis allele assignment.","volume":"62","author":"M Luo","year":"2001","journal-title":"Hum Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1034\/j.1399-0039.1999.540108.x","article-title":"High-resolution sequence typing of HLA-DQA1 and -DQB1 exon 2 DNA with taxonomy-based sequence analysis (TBSA) allele assignment.","volume":"54","author":"M Luo","year":"1999","journal-title":"Tissue Antigens"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1469-1809.1955.tb01348.x","article-title":"On estimating the relation between blood group and disease.","volume":"19","author":"B Woolf","year":"1955","journal-title":"Ann Hum Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0022948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T12:53:26Z","timestamp":1560430406000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0022948"}},"subtitle":[],"editor":[{"given":"Tian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,8,1]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0022948","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,1]]}}}