{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:14:17Z","timestamp":1790252057824,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T00:00:00Z","timestamp":1314662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024185","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T20:53:17Z","timestamp":1314737597000},"page":"e24185","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Repeated Assessment of Exploration and Novelty Seeking in the Human Behavioral Pattern Monitor in Bipolar Disorder Patients and Healthy Individuals"],"prefix":"10.1371","volume":"6","author":[{"given":"Arpi","family":"Minassian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brook L.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared W.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Masten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,8,30]]},"reference":[{"key":"ref1","first-page":"203","article-title":"Multivariate and nonlinear approaches to characterizing drug effects on the locomotor and investigatory behavior of rats.","volume":"124","author":"MA Geyer","year":"1992","journal-title":"NIDA Res Monogr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-4328(05)80262-1","article-title":"Three independent factors characterize spontaneous rat motor activity.","volume":"53","author":"MP Paulus","year":"1993","journal-title":"Behav Brain Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neubiorev.2005.08.003","article-title":"Rituals, stereotypy and compulsive behavior in animals and humans.","volume":"30","author":"D Eilam","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/15622970701416539","article-title":"Turning order into chaos through repetition and addition of elementary acts in obsessive-compulsive disorder (OCD).","volume":"10","author":"R Zor","year":"2009","journal-title":"World J Biol Psychiatry"},{"key":"ref5","first-page":"239","article-title":"Objective measures of activity and attention in the differential diagnosis of psychiatric disorders of childhood.","volume":"6","author":"GL Faedda","year":"2005","journal-title":"Essent Psychopharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0006-3223(00)01008-8","article-title":"Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism.","volume":"49","author":"K Pierce","year":"2001","journal-title":"Biological Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/archgenpsychiatry.2009.58","article-title":"A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men.","volume":"66","author":"W Perry","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neubiorev.2007.05.009","article-title":"A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor.","volume":"31","author":"JW Young","year":"2007","journal-title":"Neurosci Biobehav Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(86)90266-2","article-title":"Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses.","volume":"25","author":"MA Geyer","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jad.2009.04.018","article-title":"The quantitative assessment of motor activity in mania and schizophrenia.","volume":"120","author":"A Minassian","year":"2010","journal-title":"J Affect Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.psychres.2010.04.032","article-title":"Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm.","volume":"178","author":"W Perry","year":"2010","journal-title":"Psychiatry Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-1781(95)02684-O","article-title":"A comparison of Tridimensional Personality Questionnaire dimensions in bipolar disorder and unipolar depression.","volume":"58","author":"LT Young","year":"1995","journal-title":"Psychiatry Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: Reliability, validity and sensitivity.","volume":"133","author":"RC Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"ref14","article-title":"The LifeShirt System\u2122.","author":"Vivometrics","year":"2002"},{"key":"ref15","article-title":"Top Scan Version 1.0.","author":"CleverSystems","year":"1999"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1073\/pnas.87.2.723","article-title":"Application of entropy measures derived from the ergodic theory of dynamical systems to rat locomotor behavior.","volume":"87","author":"MP Paulus","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-3565(24)29362-9","article-title":"Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice.","volume":"298","author":"RJ Ralph","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02244547","article-title":"A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants.","volume":"104","author":"MP Paulus","year":"1991","journal-title":"Psychopharmacology (Berl)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/archgenpsychiatry.2009.58","article-title":"A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men.","volume":"66","author":"W Perry","year":"2009","journal-title":"Archives of General Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0165-0327(01)00441-4","article-title":"Toward a refined phenomenology of mania: combining clinician-assessment and self-report in the French EPIMAN study.","volume":"67","author":"HS Akiskal","year":"2001","journal-title":"Journal of Affective Disorders"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0165-0327(02)00322-1","article-title":"Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania.","volume":"73","author":"J Angst","year":"2003","journal-title":"Journal of Affective Disorders"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000096513","article-title":"Is overactivity the core feature of hypomania in bipolar II disorder?","volume":"40","author":"F Benazzi","year":"2007","journal-title":"Psychopathology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neubiorev.2010.04.002","article-title":"Cross-species assessments of motor and exploratory behavior related to bipolar disorder.","volume":"34","author":"BL Henry","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1176\/appi.ajp.159.6.1011","article-title":"Olanzapine versus divalproex in the treatment of acute mania.","volume":"159","author":"M Tohen","year":"2002","journal-title":"American Journal of Psychiatry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1034\/j.1399-5618.1999.010207.x","article-title":"Myers Briggs Type Indicator and Tridimensional Personality Questionnaire differences between bipolar patients and unipolar depressed patients.","volume":"1","author":"DS Janowsky","year":"1999","journal-title":"Bipolar Disord"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.neuropsychologia.2009.01.015","article-title":"The novelty exploration bonus and its attentional modulation.","volume":"47","author":"RM Krebs","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.1998.80.1.1","article-title":"Predictive reward signal of dopamine neurons.","volume":"80","author":"W Schultz","year":"1998","journal-title":"J Neurophysiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuron.2006.06.021","article-title":"Absolute coding of stimulus novelty in the human substantia nigra\/VTA.","volume":"51","author":"N Bunzeck","year":"2006","journal-title":"Neuron"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nn.2228","article-title":"Connectivity-based segregation of the human striatum predicts personality characteristics.","volume":"12","author":"MX Cohen","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11055-007-0058-8","article-title":"Relationship between dopamine system genes and extraversion and novelty seeking.","volume":"37","author":"VE Golimbet","year":"2007","journal-title":"Neurosci Behav Physiol"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2011.45","article-title":"Dopamine Transporter Gene Variant Affecting Expression in Human Brain is Associated with Bipolar Disorder.","author":"JK Pinsonneault","year":"2011"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0028-3908(74)90107-5","article-title":"The effect of amantadine, L-dopa, (plus)-amphetamine and apomorphine on the acquisition of the conditioned avoidance response.","volume":"13","author":"JA Davies","year":"1974","journal-title":"Neuropharmacology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yebeh.2007.09.023","article-title":"Effect of the new antiepileptic drug retigabine in a rodent model of mania.","volume":"12","author":"D Dencker","year":"2008","journal-title":"Epilepsy Behav"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(00)00318-1","article-title":"Differential sensitivity to lithium's reversal of amphetamine-induced open-field activity in two inbred strains of mice.","volume":"118","author":"TJ Gould","year":"2001","journal-title":"Behav Brain Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02815161","article-title":"Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression.","volume":"31","author":"R Li","year":"1997","journal-title":"Mol Chem Neuropathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0278-5846(90)90023-A","article-title":"Effects of lithium on an amphetamine animal model of bipolar disorder.","volume":"14","author":"P Cappeliez","year":"1990","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF00433745","article-title":"Effects of lithium on behaviour induced by phencyclidine and amphetamine in rats.","volume":"78","author":"RG Fessler","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"key":"ref38","article-title":"Predictive animal models of mania, hits, misses, and future directions.","author":"JW Young","year":"2011"},{"key":"ref39","first-page":"48","article-title":"Variational and probabilistic aspects of exploratory behavior in space: four stimulant styles.","volume":"18","author":"MA Geyer","year":"1982","journal-title":"Psychopharmacology Bulletin"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T12:24:51Z","timestamp":1741523091000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024185"}},"subtitle":[],"editor":[{"given":"James G.","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,8,30]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,8,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024185","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,30]]}}}