{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:10:13Z","timestamp":1768317013406,"version":"3.49.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T00:00:00Z","timestamp":1317340800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024379","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T20:44:07Z","timestamp":1317415447000},"page":"e24379","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Targeting KSHV\/HHV-8 Latency with COX-2 Selective Inhibitor Nimesulide: A Potential Chemotherapeutic Modality for Primary Effusion Lymphoma"],"prefix":"10.1371","volume":"6","author":[{"given":"Arun","family":"George Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Sharma-Walia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bala","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1182\/blood-2008-09-180315","article-title":"HIV-associated lymphomas and gamma-herpesviruses.","volume":"113","author":"A Carbone","year":"2009","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.pathol.1.110304.100133","article-title":"KSHV infection and the pathogenesis of Kaposi&apos;s sarcoma.","volume":"1","author":"D Ganem","year":"2006","journal-title":"Annu Rev Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/01.cco.0000172823.01190.6c","article-title":"Targeting human herpesvirus-8 for treatment of Kaposi&apos;s sarcoma and primary effusion lymphoma.","volume":"17","author":"CM Klass","year":"2005","journal-title":"Curr Opin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1172\/JCI200523334","article-title":"Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes.","volume":"115","author":"F Curreli","year":"2005","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/sj.leu.2403460","article-title":"Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas.","volume":"18","author":"J An","year":"2004","journal-title":"Leukemia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1038\/sj.onc.1204895","article-title":"Induction of a TRAIL-mediated suicide program by interferon alpha in primary effusion lymphoma.","volume":"20","author":"NL Toomey","year":"2001","journal-title":"Oncogene"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1182\/blood-2006-06-028092","article-title":"Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling.","volume":"109","author":"SH Sin","year":"2007","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI30945","article-title":"Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.","volume":"117","author":"G Sarek","year":"2007","journal-title":"J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00002030-200101260-00023","article-title":"Long-term remission of an AIDS-related primary effusion lymphoma with antiviral therapy.","volume":"15","author":"L Hocqueloux","year":"2001","journal-title":"Aids"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/sj.leu.2403646","article-title":"Treatment of herpesvirus associated primary effusion lymphoma with intracavity cidofovir.","volume":"19","author":"M Luppi","year":"2005","journal-title":"Leukemia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/annonc\/mdl139","article-title":"A non-chemotherapy treatment of a primary effusion lymphoma: durable remission after intracavitary cidofovir in HIV negative PEL refractory to chemotherapy.","volume":"17","author":"TR Halfdanarson","year":"2006","journal-title":"Ann Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1182\/blood-2009-10-251082","article-title":"Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K\/Akt\/mTOR-addicted lymphomas.","volume":"115","author":"AP Bhatt","year":"2010","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2004.047100","article-title":"Prostaglandins and cancer.","volume":"55","author":"D Wang","year":"2006","journal-title":"Gut"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1470-2045(09)70035-X","article-title":"Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement.","volume":"10","author":"J Cuzick","year":"2009","journal-title":"Lancet Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.bjp.0704365","article-title":"COX-2 and cancer: a new approach to an old problem.","volume":"134","author":"YS Bakhle","year":"2001","journal-title":"Br J Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/sj.bjc.6604010","article-title":"Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1.","volume":"97","author":"DJ de Groot","year":"2007","journal-title":"Br J Cancer"},{"key":"ref17","first-page":"717","article-title":"Chemopreventive response of diclofenac, a non-steroidal anti-inflammatory drug in experimental carcinogenesis.","volume":"24","author":"M Kaur Saini","year":"2009","journal-title":"Nutr Hosp"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/07357900801992913","article-title":"NS-398 induces apoptosis in human esophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2.","volume":"27","author":"JF Liu","year":"2009","journal-title":"Cancer Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2174\/187152006776930855","article-title":"The use of nimesulide and its analogues in cancer chemoprevention.","volume":"6","author":"JF Renard","year":"2006","journal-title":"Anticancer Agents Med Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.ejca.2005.04.013","article-title":"Cyclooxygenase-2: how good is it as a target for cancer chemoprevention?","volume":"41","author":"MA Hull","year":"2005","journal-title":"Eur J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10495-007-0148-7","article-title":"Celecoxib disrupts the canonical apoptotic network in HTLV-I cells through activation of Bax and inhibition of PKB\/Akt.","volume":"13","author":"U Sinha-Datta","year":"2008","journal-title":"Apoptosis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2004.06.014","article-title":"Cyclooxygenases in cancer: progress and perspective.","volume":"215","author":"S Zha","year":"2004","journal-title":"Cancer Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1182\/blood-2004-11-4201","article-title":"Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome.","volume":"105","author":"M Ladetto","year":"2005","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.2174\/138161208785294654","article-title":"Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise.","volume":"14","author":"MP Bernard","year":"2008","journal-title":"Curr Pharm Des"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1158\/0008-5472.CAN-03-2767","article-title":"Host gene induction and transcriptional reprogramming in Kaposi&apos;s sarcoma-associated herpesvirus (KSHV\/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection.","volume":"64","author":"PP Naranatt","year":"2004","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1158\/0008-5472.CAN-09-3934","article-title":"Piracy of prostaglandin E2\/EP receptor-mediated signaling by Kaposi&apos;s sarcoma-associated herpes virus (HHV-8) for latency gene expression: strategy of a successful pathogen.","volume":"70","author":"A George Paul","year":"2010","journal-title":"Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1128\/JVI.02333-06","article-title":"Kaposi&apos;s sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression.","volume":"81","author":"S Sadagopan","year":"2007","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1000777","DOI":"10.1371\/journal.ppat.1000777","article-title":"Kaposi&apos;s sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion.","volume":"6","author":"N Sharma-Walia","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1128\/JVI.00231-06","article-title":"Cyclooxygenase 2 induced by Kaposi&apos;s sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression.","volume":"80","author":"N Sharma-Walia","year":"2006","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3748\/wjg.v9.i5.915","article-title":"Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line.","volume":"9","author":"JY Li","year":"2003","journal-title":"World J Gastroenterol"},{"key":"ref31","first-page":"431","article-title":"Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.","volume":"48","author":"R Davis","year":"1994","journal-title":"Drugs"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1158\/1535-7163.MCT-07-0108","article-title":"Development of a fluorescence-based assay to screen antiviral drugs against Kaposi&apos;s sarcoma associated herpesvirus.","volume":"6","author":"TK Nun","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1128\/JVI.01321-09","article-title":"Distinct p53, p53:LANA, and LANA complexes in Kaposi&apos;s Sarcoma\u2013associated Herpesvirus Lymphomas.","volume":"84","author":"W Chen","year":"2010","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1016\/j.bmcl.2009.09.109","article-title":"Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.","volume":"19","author":"B Su","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2009.07.004","article-title":"Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.","volume":"289","author":"KW Wen","year":"2010","journal-title":"Cancer Lett"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nm829","article-title":"A novel viral mechanism for dysregulation of beta-catenin in Kaposi&apos;s sarcoma-associated herpesvirus latency.","volume":"9","author":"M Fujimuro","year":"2003","journal-title":"Nat Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.1116221","article-title":"Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.","volume":"310","author":"MD Castellone","year":"2005","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/70995","article-title":"Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.","volume":"5","author":"MK Jones","year":"1999","journal-title":"Nat Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000050622","article-title":"Effects of vascular endothelial growth factor and E-selectin on angiogenesis in the murine metastatic RCT sarcoma.","volume":"22","author":"M Aoki","year":"2001","journal-title":"Tumour Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1182\/blood-2002-10-3090","article-title":"Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts.","volume":"101","author":"U Klein","year":"2003","journal-title":"Blood"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1073\/pnas.1630810100","article-title":"Kaposi&apos;s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile.","volume":"100","author":"RG Jenner","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0145-2126(03)00183-8","article-title":"Increased cyclooxygenase-2 (COX-2): a potential role in the pathogenesis of lymphoma.","volume":"28","author":"T Wun","year":"2004","journal-title":"Leuk Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4161\/cbt.4.5.1699","article-title":"Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt&apos;s lymphoma in vitro and in vivo.","volume":"4","author":"A Kardosh","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0609.2005.00498.x","article-title":"Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt&apos;s lymphoma cells.","volume":"75","author":"M Kobayashi","year":"2005","journal-title":"Eur J Haematol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1182\/blood-2002-07-2072","article-title":"The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.","volume":"101","author":"Q Sun","year":"2003","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.embor.7400580","article-title":"The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling.","volume":"7","author":"I Guasparri","year":"2006","journal-title":"EMBO Rep"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/47266","article-title":"p53 inhibition by the LANA protein of KSHV protects against cell death.","volume":"402","author":"J Friborg Jr","year":"1999","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/nm0901-1041","article-title":"NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42\/Rac-dependent endothelial-cell spreading, migration and angiogenesis.","volume":"7","author":"O Dormond","year":"2001","journal-title":"Nat Med"},{"key":"ref49","first-page":"pe18","article-title":"Syndecans shed their reputation as inert molecules.","volume":"2","author":"MD Bass","year":"2009","journal-title":"Sci Signal"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2009.09.005","article-title":"The yin and yang of vitamin D receptor (VDR) signaling in neoplastic progression: operational networks and tissue-specific growth control.","volume":"79","author":"FC Campbell","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-008-0303-9","article-title":"Aquaporins\u2013new players in cancer biology.","volume":"86","author":"AS Verkman","year":"2008","journal-title":"J Mol Med"},{"key":"ref52","first-page":"3178","article-title":"Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts.","volume":"7","author":"RD Blumenthal","year":"2001","journal-title":"Clin Cancer Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3322\/canjclin.51.1.15","article-title":"Cancer statistics, 2001.","volume":"51","author":"RT Greenlee","year":"2001","journal-title":"CA Cancer J Clin"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T20:53:40Z","timestamp":1560718420000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024379"}},"subtitle":[],"editor":[{"given":"Elankumaran","family":"Subbiah","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,30]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024379","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,30]]}}}