{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:53:17Z","timestamp":1789480397476,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024544","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T06:11:48Z","timestamp":1316067108000},"page":"e24544","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Systemic Maternal Inflammation and Neonatal Hyperoxia Induces Remodeling and Left Ventricular Dysfunction in Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Markus","family":"Velten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk R.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Gorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren E.","family":"Wold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Lucchesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette K.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease.","volume":"2","author":"DJ Barker","year":"1989","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bmj.297.6641.134-b","article-title":"Low birth weight and hypertension.","volume":"297","author":"DJ Barker","year":"1988","journal-title":"BMJ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3L","DOI":"10.1016\/S0002-9149(02)02953-3","article-title":"Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study.","volume":"90","author":"GS Berenson","year":"2002","journal-title":"Am J Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/pdp.21.2.213.237","article-title":"Natural history and risk factors of atherosclerosis in children and youth: the PDAY study.","volume":"21","author":"AW Zieske","year":"2002","journal-title":"Pediatr Pathol Mol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/hc1102.106792","article-title":"Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray.","volume":"105","author":"C Napoli","year":"2002","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1096\/fj.02-0226rev","article-title":"The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis.","volume":"16","author":"W Palinski","year":"2002","journal-title":"FASEB J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCULATIONAHA.107.750133","article-title":"Impaired fetal growth, cardiovascular disease, and the need to move on.","volume":"117","author":"W Palinski","year":"2008","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3109\/14767058.2010.482618","article-title":"Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.","volume":"23","author":"R Romero","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1471-0528.2005.00827.x","article-title":"Periodontal disease and adverse pregnancy outcomes: a systematic review.","volume":"113","author":"X Xiong","year":"2006","journal-title":"BJOG"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14767050802531813","article-title":"Previous abortion and risk of pre-term birth: a population study.","volume":"22","author":"R Freak-Poli","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/14767050701516063","article-title":"Acute and chronic respiratory diseases in pregnancy: associations with spontaneous premature rupture of membranes.","volume":"20","author":"D Getahun","year":"2007","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth.","volume":"25","author":"R Romero","year":"2007","journal-title":"Semin Reprod Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery.","volume":"342","author":"RL Goldenberg","year":"2000","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12265-009-9108-7","article-title":"Influence of Maternal Dysmetabolic Conditions During Pregnancy on Cardiovascular Disease.","volume":"2","author":"W Palinski","year":"2009","journal-title":"J Cardiovasc Transl Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.earlhumdev.2011.01.043","article-title":"Early postnatal blood concentrations of inflammation-related proteins and microcephaly two years later in infants born before the 28th post-menstrual week.","volume":"87","author":"A Leviton","year":"2011","journal-title":"Early Hum Dev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/euhj.2000.2147","article-title":"Maternal hypercholesterolemia during pregnancy influences the later development of atherosclerosis: clinical and pathogenic implications.","volume":"22","author":"C Napoli","year":"2001","journal-title":"Eur Heart J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1152\/ajpregu.00435.2004","article-title":"Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms.","volume":"288","author":"S McMullen","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cvr\/cvn341","article-title":"Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood.","volume":"81","author":"CF Rueda-Clausen","year":"2009","journal-title":"Cardiovasc Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cardiores.2004.12.003","article-title":"Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart.","volume":"65","author":"CV Rohlicek","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref20","first-page":"R2022","article-title":"Cardiac beta-adrenergic receptor function in fetal sheep exposed to long-term high-altitude hypoxemia.","volume":"273","author":"VA Browne","year":"1997","journal-title":"Am J Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"R258","DOI":"10.1152\/ajpregu.00167.2009","article-title":"Chronic prenatal hypoxia sensitizes beta-adrenoceptors in the embryonic heart but causes postnatal desensitization.","volume":"297","author":"I Lindgren","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"H983","DOI":"10.1152\/ajpheart.00005.2003","article-title":"Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart.","volume":"285","author":"S Bae","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1161\/HYPERTENSIONAHA.108.116251","article-title":"Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood.","volume":"52","author":"C Yzydorczyk","year":"2008","journal-title":"Hypertension"},{"key":"ref24","article-title":"Myocardial Response in Preterm Fetal Sheep Exposed to Systemic Endotoxinaemia.","author":"M Seehase","year":"2011","journal-title":"Pediatr Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.bjp.0706129","article-title":"Prenatal cocaine exposure increases apoptosis of neonatal rat heart and heart susceptibility to ischemia-reperfusion injury in 1-month-old rat.","volume":"144","author":"S Bae","year":"2005","journal-title":"Br J Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/jn\/128.10.1589","article-title":"Soy protein, isoflavones and cardiovascular disease risk.","volume":"128","author":"AH Lichtenstein","year":"1998","journal-title":"J Nutr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2007-994739","article-title":"Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies.","volume":"10","author":"JC Veille","year":"1993","journal-title":"Am J Perinatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1203\/01.PDR.0000061564.86797.78","article-title":"Cardiac hypertrophy and altered hemodynamic adaptation in growth-restricted preterm infants.","volume":"53","author":"JA Leipala","year":"2003","journal-title":"Pediatr Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1469-0705.2002.00734.x","article-title":"Cardiac ventricular performance in the appropriate- for-gestational age and small-for-gestational age fetus: relation to regional cardiac non-uniformity and peripheral resistance.","volume":"20","author":"P Tsyvian","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/toxsci\/kfi302","article-title":"Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy.","volume":"88","author":"EA Thackaberry","year":"2005","journal-title":"Toxicol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"R360","DOI":"10.1152\/ajpregu.00178.2004","article-title":"Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats.","volume":"288","author":"SJ Williams","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1071-5576(00)00066-6","article-title":"Chronic hypoxia and developmental regulation of cytochrome c expression in rats.","volume":"7","author":"D Xiao","year":"2000","journal-title":"J Soc Gynecol Investig"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1152\/japplphysiol.00951.2007","article-title":"Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats.","volume":"104","author":"MP Bal","year":"2008","journal-title":"J Appl Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-3782(97)00122-9","article-title":"Abnormal left ventricular diastolic filling patterns in small-for-gestational-age infants.","volume":"51","author":"K Harada","year":"1998","journal-title":"Early Hum Dev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1071-5576(02)00180-6","article-title":"Effects of long-term hypoxia and development on cardiac contractile proteins in fetal and adult sheep.","volume":"9","author":"M Kamitomo","year":"2002","journal-title":"J Soc Gynecol Investig"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1161\/CIRCULATIONAHA.110.937995","article-title":"Fetal growth restriction results in remodeled and less efficient hearts in children.","volume":"121","author":"F Crispi","year":"2010","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/01.CIR.0000038110.69369.4C","article-title":"CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction.","volume":"106","author":"P Knuefermann","year":"2002","journal-title":"Circulation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/01.shk.0000196498.57306.a6","article-title":"Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia.","volume":"25","author":"G Baumgarten","year":"2006","journal-title":"Shock"},{"key":"ref39","article-title":"Maternal inflammation, growth retardation, and preterm birth: Insights into adult cardiovascular disease.","author":"LK Rogers","year":"2011","journal-title":"Life Sciences"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10741-008-9125-7","article-title":"Cardiac hypertrophy and thyroid hormone signaling.","volume":"15","author":"W Dillmann","year":"2010","journal-title":"Heart Fail Rev"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1006\/jmcc.1996.0300","article-title":"Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency.","volume":"29","author":"K Yoshimine","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00123828","article-title":"Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro.","volume":"15","author":"DE Harris","year":"1994","journal-title":"J Muscle Res Cell Motil"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/01.RES.0000022879.57270.11","article-title":"Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments.","volume":"90","author":"TJ Herron","year":"2002","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0022-2828(89)90805-5","article-title":"Alpha-myosin heavy chain cDNA structure and gene expression in adult, fetal, and premature baboon myocardium.","volume":"21","author":"JE Hixson","year":"1989","journal-title":"J Mol Cell Cardiol"},{"key":"ref45","article-title":"Inhibition of NADPH oxidase up-regulates connexin 43 and ameliorates electrical remodeling in rabbits with heart failure.","author":"Y Liu","year":"2010","journal-title":"Biomed Pharmacother"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/CIRCRESAHA.108.182147","article-title":"Ultrastructure and regulation of lateralized connexin43 in the failing heart.","volume":"106","author":"GG Hesketh","year":"2010","journal-title":"Circ Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1476-5381.2009.00372.x","article-title":"Stimulation of cardiac beta-adrenoceptors targets connexin 43.","volume":"158","author":"K Boengler","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.","volume":"107","author":"M Zhang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1073\/pnas.091415198","article-title":"A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.","volume":"98","author":"FJ Giordano","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","article-title":"Significant QT interval prolongation and long QT in young adult ex-preterm newborns with extremely low birth weight.","author":"PP Bassareo","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.yjmcc.2005.03.014","article-title":"Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats.","volume":"39","author":"LE Wold","year":"2005","journal-title":"J Mol Cell Cardiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:06:27Z","timestamp":1589043987000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024544"}},"subtitle":[],"editor":[{"given":"Amit","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,14]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024544","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,14]]}}}