{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:10:08Z","timestamp":1761718208237},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024561","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T17:53:08Z","timestamp":1330537988000},"page":"e24561","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polymorphisms in the Presumptive Promoter Region of the SLC2A9 Gene Are Associated with Gout in a Chinese Male Population"],"prefix":"10.1371","volume":"7","author":[{"given":"Changgui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peisu","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"ref1","first-page":"1859","article-title":"Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China.","volume":"35","author":"Z Miao","year":"2008","journal-title":"J Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7326\/0003-4819-143-7-200510040-00009","article-title":"Pathogenesis of gout.","volume":"143","author":"HK Choi","year":"2005","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/art.22466","article-title":"Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey.","volume":"57","author":"HK Choi","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/rheumatology\/ken305","article-title":"Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile.","volume":"47","author":"HK Choi","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1136\/ard.2006.055251","article-title":"EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).","volume":"65","author":"W Zhang","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/ar1909","article-title":"Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics.","volume":"8","author":"R Terkeltaub","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"ref7","first-page":"1647","article-title":"Clinical practice. Gout.","volume":"349","author":"RA Terkeltaub","year":"2003","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/rheumatology\/ken460","article-title":"Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout.","volume":"48","author":"N Dalbeth","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1371\/journal.pmed.0050197","article-title":"SLC2A9 is a high-capacity urate transporter in humans.","volume":"5","author":"MJ Caulfield","year":"2008","journal-title":"PLoS Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ng.106","article-title":"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.","volume":"40","author":"V Vitart","year":"2008","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng.107","article-title":"SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.","volume":"40","author":"A Doring","year":"2008","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"16229","DOI":"10.1074\/jbc.M312226200","article-title":"Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.","volume":"279","author":"R Augustin","year":"2004","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/joca.2002.0858","article-title":"Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.","volume":"11","author":"S Richardson","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2008.11.001","article-title":"Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia.","volume":"83","author":"H Matsuo","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1681\/ASN.2009040406","article-title":"Homozygous SLC2A9 mutations cause severe renal hypouricemia.","volume":"21","author":"D Dinour","journal-title":"J Am Soc Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/art.23752","article-title":"Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.","volume":"58","author":"PF McArdle","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1371\/journal.pgen.0030194","article-title":"The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.","volume":"3","author":"S Li","year":"2007","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajhg.2007.11.001","article-title":"Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.","volume":"82","author":"C Wallace","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.2337\/dc08-0349","article-title":"Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI.","volume":"31","author":"A Brandstatter","year":"2008","journal-title":"Diabetes Care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.","volume":"372","author":"A Dehghan","year":"2008","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3325\/cmj.2009.50.23","article-title":"Genome-wide association study of biochemical traits in Korcula Island, Croatia.","volume":"50","author":"T Zemunik","year":"2009","journal-title":"Croat Med J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000504","DOI":"10.1371\/journal.pgen.1000504","article-title":"Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.","volume":"5","author":"M Kolz","year":"2009","journal-title":"PLoS Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.atherosclerosis.2009.12.013","article-title":"Sex and age interaction with genetic association of atherogenic uric acid concentrations.","volume":"210","author":"A Brandstatter","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ejhg.2010.97","article-title":"Genome-wide scan identifies a quantitative trait locus at 4p15.3 for serum urate.","volume":"18","author":"N Cummings","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1948","DOI":"10.1371\/journal.pone.0001948","article-title":"Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.","volume":"3","author":"K Stark","year":"2008","journal-title":"PLoS One"},{"key":"ref26","first-page":"887","article-title":"Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders.","volume":"69","author":"HP Tu","journal-title":"Ann Rheum Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/art.24938","article-title":"Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Maori, Pacific Island, and Caucasian case-control sample sets.","volume":"60","author":"JE Hollis-Moffatt","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e7729","DOI":"10.1371\/journal.pone.0007729","article-title":"Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.","volume":"4","author":"K Stark","year":"2009","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3325\/cmj.2010.51.48","article-title":"Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.","volume":"51","author":"O Polasek","year":"2010","journal-title":"Croat Med J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/ard.2009.111096","article-title":"Association between GLUT9 and gout in Japanese men.","volume":"69","author":"W Urano","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","article-title":"Preliminary criteria for the classification of the acute arthritis of primary gout.","volume":"20","author":"SL Wallace","year":"1977","journal-title":"Arthritis Rheum"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps.","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/ard.2004.024091","article-title":"Gout epidemiology: results from the UK General Practice Research Database, 1990\u20131999.","volume":"64","author":"TR Mikuls","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"26834","DOI":"10.1074\/jbc.C800156200","article-title":"Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.","volume":"283","author":"N Anzai","year":"2008","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"F612","DOI":"10.1152\/ajprenal.00139.2009","article-title":"Mouse GLUT9: evidences for a urate uniporter.","volume":"297","author":"S Bibert","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref36","first-page":"2368","article-title":"Tophaceous gout: quantitative evaluation by direct physical measurement.","volume":"32","author":"HR Schumacher Jr","year":"2005","journal-title":"J Rheumatol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/cbir.2001.0850","article-title":"Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9.","volume":"26","author":"A Mobasheri","year":"2002","journal-title":"Cell Biol Int"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1042\/bj3500771","article-title":"Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.","volume":"350 Pt 3","author":"H Doege","year":"2000","journal-title":"Biochem J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T11:45:59Z","timestamp":1540295159000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024561"}},"subtitle":[],"editor":[{"given":"Adrian","family":"Vella","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024561","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}