{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:41:58Z","timestamp":1780411318351,"version":"3.54.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024599","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T20:53:54Z","timestamp":1314996834000},"page":"e24599","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Expression of Prion Protein in Mouse Erythroid Progenitors and Differentiating Murine Erythroleukemia Cells"],"prefix":"10.1371","volume":"6","author":[{"given":"Martin","family":"Panigaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Glier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Wildova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Holada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1152\/physrev.00007.2007","article-title":"Physiology of the prion protein.","volume":"88","author":"R Linden","year":"2008","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jnr.10864","article-title":"Neuroprotective functions of prion protein.","volume":"75","author":"X Roucou","year":"2004","journal-title":"J Neurosci Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e6115","DOI":"10.1371\/journal.pone.0006115","article-title":"Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.","volume":"4","author":"A Singh","year":"2009","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.brainresrev.2009.06.002","article-title":"New insights into cellular prion protein (PrPc) functions: the \u201cying and yang\u201d of a relevant protein.","volume":"61","author":"O Nicolas","year":"2009","journal-title":"Brain Res Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/85515","article-title":"A novel erythroid-specific marker of transmissible spongiform encephalopathies.","volume":"7","author":"G Miele","year":"2001","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbrc.2007.10.015","article-title":"Differential expression of erythroid genes in prion disease.","volume":"364","author":"AR Brown","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bcmd.2007.09.009","article-title":"Reduced erythroid cell and erythropoietin production in response to acute anemia in prion protein-deficient (Prnp-\/-) mice.","volume":"40","author":"JH Zivny","year":"2008","journal-title":"Blood Cells Mol Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1073\/pnas.0510577103","article-title":"Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.","volume":"103","author":"CC Zhang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1182\/blood.V91.5.1556","article-title":"Prion protein expression in human leukocyte differentiation.","volume":"91","author":"VC Dodelet","year":"1998","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0301-472X(02)01011-1","article-title":"CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc).","volume":"31","author":"AM Risitano","year":"2003","journal-title":"Exp Hematol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1365-2141.2000.02158.x","article-title":"Different levels of prion protein (PrPc) expression on hamster, mouse and human blood cells.","volume":"110","author":"K Holada","year":"2000","journal-title":"Br J Haematol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/j.1537-2995.2010.02924.x","article-title":"Underestimation of the expression of cellular prion protein on human red blood cells.","volume":"51","author":"M Panigaj","year":"2010","journal-title":"Transfusion"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1289\/ehp.8980181","article-title":"Induced differentiation of erythroleukemia cells by hexamethylene bisacetamide: a model for cytodifferentiation of transformed cells.","volume":"80","author":"PA Marks","year":"1989","journal-title":"Environ Health Perspect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1006\/excr.2001.5151","article-title":"Transcriptional activation of prion protein gene in growth-arrested and differentiated mouse erythroleukemia and human neoplastic cells.","volume":"264","author":"DD Gougoumas","year":"2001","journal-title":"Exp Cell Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/j.1537-2995.2007.01451.x","article-title":"Divergent expression of cellular prion protein on blood cells of human and nonhuman primates.","volume":"47","author":"K Holada","year":"2007","journal-title":"Transfusion"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1182\/blood-2007-04-085183","article-title":"Normal prion protein trafficking in cultured human erythroblasts.","volume":"110","author":"RE Griffiths","year":"2007","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0301-472X(01)00616-6","article-title":"Structural characterization of erythroid and megakaryocytic differentiation in Friend erythroleukemia cells.","volume":"29","author":"T Hyman","year":"2001","journal-title":"Exp Hematol"},{"key":"ref18","first-page":"440","article-title":"Effect of hexamethylene bisacetamide on the commitment to differentiation of murine erythroleukemia cells.","volume":"37","author":"E Fibach","year":"1977","journal-title":"Cancer Res"},{"key":"ref19","first-page":"159","article-title":"Upstream AUGs modulate prion protein translation in vitro.","volume":"46","author":"B Schroder","year":"2002","journal-title":"Acta Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0306-4522(01)00603-0","article-title":"A marked disparity between the expression of prion protein and its message by neurones of the CNS.","volume":"111","author":"MJ Ford","year":"2002","journal-title":"Neuroscience"},{"key":"ref21","first-page":"75","article-title":"Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL.","volume":"56","author":"Y Otsuka","year":"2008","journal-title":"Jpn J Vet Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2009-0332","article-title":"Minireview: Nuclear receptors, hematopoiesis, and stem cells.","volume":"24","author":"JP Chute","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1073\/pnas.82.15.5020","article-title":"Gene expression during terminal differentiation: dexamethasone suppression of inducer-mediated alpha 1- and beta maj-globin gene expression.","volume":"82","author":"T Kaneda","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.4161\/cbt.6.9.4765","article-title":"Cell cycle arrest by glucocorticoids may protect normal tissue and solid tumors from cancer therapy.","volume":"6","author":"J Mattern","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"ref25","first-page":"513","article-title":"Effect of dexamethasone on hexamethylene bisacetamide-induced Friend cell erythrodifferentiation.","volume":"42","author":"HB Osborne","year":"1982","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0006-291X(03)00805-2","article-title":"Efficient and specific down-regulation of prion protein expression by RNAi.","volume":"305","author":"G Tilly","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1172\/JCI29236","article-title":"Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice.","volume":"116","author":"A Pfeifer","year":"2006","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e4468","DOI":"10.1371\/journal.pone.0004468","article-title":"Prion protein modulates cellular iron uptake: a novel function with implications for prion disease pathogenesis.","volume":"4","author":"A Singh","year":"2009","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e16804","DOI":"10.1371\/journal.pone.0016804","article-title":"Decreased CSF Transferrin in sCJD: A Potential Pre-Mortem Diagnostic Test for Prion Disorders.","volume":"6","author":"A Singh","year":"2011","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1128\/MCB.8.2.884","article-title":"Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation.","volume":"8","author":"MF Clarke","year":"1988","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/sj.onc.1205003","article-title":"A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state.","volume":"21","author":"J Chen","year":"2002","journal-title":"Oncogene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00109-004-0605-5","article-title":"Cellular prion protein neuroprotective function: implications in prion diseases.","volume":"83","author":"X Roucou","year":"2005","journal-title":"J Mol Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jcp.20969","article-title":"Activation of Prn-p gene and stable transfection of Prn-p cDNA in leukemia MEL and neuroblastoma N2a cells increased production of PrP(C) but not prevented DNA fragmentation initiated by serum deprivation.","volume":"211","author":"DD Gougoumas","year":"2007","journal-title":"J Cell Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-3-11","article-title":"Prion protein lacks robust cytoprotective activity in cultured cells.","volume":"3","author":"HM Christensen","year":"2008","journal-title":"Mol Neurodegener"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1093\/emboj\/20.21.5863","article-title":"The 37-kDa\/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein.","volume":"20","author":"S Gauczynski","year":"2001","journal-title":"EMBO J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0169-328X(99)00334-4","article-title":"Cellular prion protein binds laminin and mediates neuritogenesis.","volume":"76","author":"E Graner","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1182\/blood-2005-11-4458","article-title":"Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.","volume":"108","author":"Y Liu","year":"2006","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nmeth923","article-title":"Lessons from Nature: microRNA-based shRNA libraries.","volume":"3","author":"K Chang","year":"2006","journal-title":"Nat Methods"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.exphem.2006.10.007","article-title":"Proteomic analysis of erythroid differentiation induced by hexamethylene bisacetamide in murine erythroleukemia cells.","volume":"35","author":"J Petrak","year":"2007","journal-title":"Exp Hematol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T03:18:32Z","timestamp":1592882312000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024599"}},"subtitle":[],"editor":[{"given":"Jiyan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,2]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024599","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,2]]}}}