{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:40:45Z","timestamp":1790419245067,"version":"4.1.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T00:00:00Z","timestamp":1317254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024917","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T21:38:34Z","timestamp":1317332314000},"page":"e24917","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1"],"prefix":"10.1371","volume":"6","author":[{"given":"Xiaohua","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid S.","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Nalepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Snider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Robling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Wade","family":"Clapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Guise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/(SICI)1098-2795(199701)46:1<75::AID-MRD12>3.0.CO;2-2","article-title":"Role of CSF-1 in bone and bone marrow development.","volume":"46","author":"MG Cecchini","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling.","volume":"11","author":"EF Eriksen","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nature02041","article-title":"Identification of the haematopoietic stem cell niche and control of the niche size.","volume":"425","author":"J Zhang","year":"2003","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nature04957","article-title":"The stem-cell niche as an entity of action.","volume":"441","author":"DT Scadden","year":"2006","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.2134734","article-title":"Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.","volume":"249","author":"MR Wallace","year":"1990","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1046\/j.1523-1747.2000.00994.x","article-title":"The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL\/6 mice.","volume":"114","author":"RP Atit","year":"2000","journal-title":"J Invest Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1523-1747.1999.00609.x","article-title":"The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts.","volume":"112","author":"RP Atit","year":"1999","journal-title":"J Invest Dermatol"},{"key":"ref8","first-page":"8573","article-title":"Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.","volume":"63","author":"ML Bajenaru","year":"2003","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(01)00245-8","article-title":"NF1 tumor suppressor gene function: narrowing the GAP.","volume":"104","author":"K Cichowski","year":"2001","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ng0996-110","article-title":"Identification of NF1 mutations in both alleles of a dermal neurofibroma.","volume":"14","author":"S Sawada","year":"1996","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/1098-2264(200008)28:4<425::AID-GCC8>3.0.CO;2-E","article-title":"Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1.","volume":"28","author":"SA Rasmussen","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2008.08.041","article-title":"Nf1-dependent tumors require a microenvironment containing Nf1+\/\u2212 and c-kit-dependent bone marrow.","volume":"135","author":"FC Yang","year":"2008","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/NEN.0b013e3182032d37","article-title":"Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth.","volume":"70","author":"GW Simmons","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/hmg\/ddm059","article-title":"Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth.","volume":"16","author":"GC Daginakatte","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.1068452","article-title":"Neurofibromas in NF1: Schwann cell origin and role of tumor environment.","volume":"296","author":"Y Zhu","year":"2002","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4049\/jimmunol.166.1.552","article-title":"The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.","volume":"166","author":"MN Ajuebor","year":"2001","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/hmg\/9.7.1059","article-title":"Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1.","volume":"9","author":"JL Rutkowski","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.191.1.181","article-title":"Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo.","volume":"191","author":"DA Ingram","year":"2000","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1172\/JCI19195","article-title":"Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+\/\u2212 mast cells.","volume":"112","author":"FC Yang","year":"2003","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1073\/pnas.0503224102","article-title":"The NF1 tumor suppressor critically regulates TSC2 and mTOR.","volume":"102","author":"CM Johannessen","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.prp.2006.03.006","article-title":"Vasculopathy in two cases of NF1-related congenital pseudarthrosis.","volume":"202","author":"T Kuorilehto","year":"2006","journal-title":"Pathol Res Pract"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1359\/JBMR.040130","article-title":"NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos.","volume":"19","author":"T Kuorilehto","year":"2004","journal-title":"J Bone Miner Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s00198-004-1801-4","article-title":"Decreased bone mineral density and content in neurofibromatosis type 1: lowest local values are located in the load-carrying parts of the body.","volume":"16","author":"T Kuorilehto","year":"2005","journal-title":"Osteoporos Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00198-005-1940-2","article-title":"Decreased bone mineral density in patients with neurofibromatosis 1.","volume":"16","author":"M Lammert","year":"2005","journal-title":"Osteoporos Int"},{"key":"ref25","first-page":"180","article-title":"[Imaging features of neurofibromatosis type 1].","volume":"32","author":"C Jacques","year":"2005","journal-title":"J Neuroradiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s001980170032","article-title":"Decreased bone mineral density in neurofibromatosis-1 patients with spinal deformities.","volume":"12","author":"T Illes","year":"2001","journal-title":"Osteoporos Int"},{"key":"ref27","first-page":"105","article-title":"[Difficult surgical management of facial neurofibromatosis type I or von Recklinghausen disease in children].","volume":"103","author":"Y Heuze","year":"2002","journal-title":"Rev Stomatol Chir Maxillofac"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jpeds.2006.10.048","article-title":"Bone mineral density in children and adolescents with neurofibromatosis type 1.","volume":"150","author":"DA Stevenson","year":"2007","journal-title":"J Pediatr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1086\/504441","article-title":"Double inactivation of NF1 in tibial pseudarthrosis.","volume":"79","author":"DA Stevenson","year":"2006","journal-title":"Am J Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1002\/ajmg.a.31368","article-title":"The new bone biology: pathologic, molecular, and clinical correlates.","volume":"140","author":"MM Cohen Jr","year":"2006","journal-title":"Am J Med Genet A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1172\/JCI29092","article-title":"Hyperactivation of p21 and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.","volume":"116","author":"FC Yang","year":"2006","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/hmg\/ddm032","article-title":"Multiple roles for neurofibromin in skeletal development and growth.","volume":"16","author":"M Kolanczyk","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cmet.2006.10.010","article-title":"ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.","volume":"4","author":"F Elefteriou","year":"2006","journal-title":"Cell Metab"},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.42","article-title":"Local low dose lovastatin delivery improves the bone healing defect caused by Nf1 loss-of-function in osteoblasts.","author":"W Wang","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/dvdy.10453","article-title":"Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction.","volume":"229","author":"A Kruzynska-Frejtag","year":"2004","journal-title":"Dev Dyn"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"19700","DOI":"10.1074\/jbc.M601856200","article-title":"Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.","volume":"281","author":"W Yan","year":"2006","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ydbio.2007.04.041","article-title":"Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer.","volume":"307","author":"A Lindsley","year":"2007","journal-title":"Dev Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1172\/JCI40295","article-title":"Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.","volume":"120","author":"N Takeda","year":"2010","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.1128\/MCB.25.24.11131-11144.2005","article-title":"periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype.","volume":"25","author":"H Rios","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref40","article-title":"Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model.","author":"W Zhang","year":"2011","journal-title":"Bone"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1210\/en.2004-1259","article-title":"Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth.","volume":"146","author":"SJ Warden","year":"2005","journal-title":"Endocrinology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/(SICI)1096-8628(19990611)84:5<413::AID-AJMG5>3.0.CO;2-1","article-title":"Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1.","volume":"84","author":"DA Stevenson","year":"1999","journal-title":"Am J Med Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/dvdy.10100","article-title":"Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast.","volume":"224","author":"R Dacquin","year":"2002","journal-title":"Dev Dyn"},{"key":"ref44","first-page":"608","article-title":"Osseous manifestations of neurofibromatosis (Recklinghausen&apos;s disease).","volume":"32","author":"P Marques","year":"1951","journal-title":"J Radiol Electrol Arch Electr Medicale"},{"key":"ref45","first-page":"393","article-title":"[Osseous manifestations of Recklinghausen&apos;s disease. The role of vertebral scalloping].","volume":"2","author":"A Sbihi","year":"1980","journal-title":"Maroc Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01241398-198601000-00015","article-title":"Osseous manifestations of neurofibromatosis in childhood.","volume":"6","author":"AH Crawford Jr","year":"1986","journal-title":"J Pediatr Orthop"},{"key":"ref47","first-page":"29","article-title":"Pitfalls of spinal deformities associated with neurofibromatosis in children.","author":"AH Crawford","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"ref48","article-title":"Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning.","author":"X Yu","year":"2005","journal-title":"Bone"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/hmg\/ddl208","article-title":"Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem\/progenitor cells.","volume":"15","author":"X Wu","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng0794-353","article-title":"Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.","volume":"7","author":"T Jacks","year":"1994","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ccr.2008.01.003","article-title":"The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.","volume":"13","author":"NM Joseph","year":"2008","journal-title":"Cancer Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1387\/ijdb.041816fl","article-title":"Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues.","volume":"48","author":"F Liu","year":"2004","journal-title":"Int J Dev Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1128\/MCB.00920-08","article-title":"The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.","volume":"28","author":"V Munugalavadla","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e2942","DOI":"10.1371\/journal.pone.0002942","article-title":"Control of bone mass and remodeling by PTH receptor signaling in osteocytes.","volume":"3","author":"CA O'Brien","year":"2008","journal-title":"PLoS ONE"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jor.1100020115","article-title":"Production of a standard closed fracture in laboratory animal bone.","volume":"2","author":"F Bonnarens","year":"1984","journal-title":"J Orthop Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jor.21078","article-title":"Modulation of Wnt signaling influences fracture repair.","volume":"28","author":"DE Komatsu","journal-title":"J Orthop Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bone.2008.11.007","article-title":"Recombinant human parathyroid hormone (PTH 1\u201334) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing.","volume":"44","author":"SJ Warden","year":"2009","journal-title":"Bone"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(97)00313-X","article-title":"\u2018Green mice\u2019 as a source of ubiquitous green cells.","volume":"407","author":"M Okabe","year":"1997","journal-title":"FEBS Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T07:03:42Z","timestamp":1593068622000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024917"}},"subtitle":[],"editor":[{"given":"Pranela","family":"Rameshwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,29]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024917","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,29]]}}}