{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:52:13Z","timestamp":1791193933507,"version":"4.1.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0025138","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T21:14:38Z","timestamp":1316726078000},"page":"e25138","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Accelerated CCl4-Induced Liver Fibrosis in Hjv-\/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression"],"prefix":"10.1371","volume":"6","author":[{"given":"Giada","family":"Sebastiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Gkouvatsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Maffettone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Busatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Guido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Pantopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408360701713104","article-title":"Oxidative stress and iron homeostasis: mechanistic and health aspects.","volume":"45","author":"D Galaris","year":"2008","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMra031573","article-title":"Hereditary hemochromatosis - a new look at an old disease.","volume":"350","author":"A Pietrangelo","year":"2004","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrgastro.2009.201","article-title":"Genetic mechanisms and modifying factors in hereditary hemochromatosis.","volume":"7","author":"G Weiss","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.med.57.121304.131310","article-title":"Hemochromatosis: genetics and pathophysiology.","volume":"57","author":"E Beutler","year":"2006","journal-title":"Annu Rev Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nrm2295","article-title":"Regulation of iron acquisition and storage: consequences for iron-linked disorders.","volume":"9","author":"I De Domenico","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000243791","article-title":"The role of hepcidin in iron metabolism.","volume":"122","author":"E Nemeth","year":"2009","journal-title":"Acta Haematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","article-title":"Iron homeostasis.","volume":"69","author":"NC Andrews","year":"2007","journal-title":"Annu Rev Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.pathol.4.110807.092205","article-title":"Regulation of hepcidin and iron-overload disease.","volume":"4","author":"PL Lee","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.","volume":"13","author":"JN Feder","year":"1996","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng1274","article-title":"Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.","volume":"36","author":"G Papanikolaou","year":"2004","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.","volume":"38","author":"JL Babitt","year":"2006","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.gastro.2004.09.019","article-title":"Iron, hemochromatosis, and hepatocellular carcinoma.","volume":"127","author":"KV Kowdley","year":"2004","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1055\/s-2005-923315","article-title":"Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis.","volume":"25","author":"GA Ramm","year":"2005","journal-title":"Semin Liver Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jhep.2010.03.001","article-title":"EASL clinical practice guidelines for HFE hemochromatosis.","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.23333","article-title":"Hemochromatosis in Italy in the last 30 years: role of genetic and acquired factors.","volume":"51","author":"AL Fracanzani","year":"2010","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1055\/s-2005-923317","article-title":"Iron in nonhemochromatotic liver disorders.","volume":"25","author":"V Alla","year":"2005","journal-title":"Semin Liver Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.3748\/wjg.v13.i35.4673","article-title":"HFE gene in primary and secondary hepatic iron overload.","volume":"13","author":"G Sebastiani","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis.","volume":"134","author":"SL Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1053\/j.gastro.2004.08.028","article-title":"From quiescence to activation: Gene regulation in hepatic stellate cells.","volume":"127","author":"RA Rippe","year":"2004","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ.","volume":"117","author":"JP Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"ref21","first-page":"237","article-title":"Modeling liver fibrosis in rodents.","volume":"117","author":"C Constandinou","year":"2005","journal-title":"Methods Mol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2006-927387","article-title":"Mouse models of liver fibrosis.","volume":"45","author":"C Weiler-Normann","year":"2007","journal-title":"Z Gastroenterol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S1357-2725(02)00298-4","article-title":"Iron overload enhances the development of experimental liver cirrhosis in mice.","volume":"35","author":"B Arezzini","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/hep.1840210430","article-title":"Iron overload facilitates hepatic fibrosis in the rat alcohol\/low-dose carbon tetrachloride model.","volume":"21","author":"M Mackinnon","year":"1995","journal-title":"Hepatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1172\/JCI118077","article-title":"Experimental liver cirrhosis induced by alcohol and iron.","volume":"96","author":"H Tsukamoto","year":"1995","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2008.08.024","article-title":"Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis.","volume":"254","author":"GA Asare","year":"2008","journal-title":"Toxicology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0168-8278(99)80201-3","article-title":"Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation.","volume":"30","author":"GS Wang","year":"1999","journal-title":"J Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0168-8278(95)80222-3","article-title":"A long-term study of the interaction between iron and alcohol in an animal model of iron overload.","volume":"22","author":"J Olynyk","year":"1995","journal-title":"J Hepatol"},{"key":"ref29","first-page":"217","article-title":"A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload.","volume":"69","author":"P Carthew","year":"1993","journal-title":"Lab Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1172\/JCI117861","article-title":"Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents.","volume":"95","author":"A Pietrangelo","year":"1995","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1172\/JCI25049","article-title":"A mouse model of juvenile hemochromatosis.","volume":"115","author":"FW Huang","year":"2005","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1172\/JCI25683","article-title":"Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.","volume":"115","author":"V Niederkofler","year":"2005","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","article-title":"Anemia of chronic disease.","volume":"352","author":"G Weiss","year":"2005","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1365-2362.2002.0320s1050.x","article-title":"Nature of nontransferrin-bound iron.","volume":"32","author":"RC Hider","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1182\/blood-2004-06-2422","article-title":"Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin.","volume":"104","author":"J Krijt","year":"2004","journal-title":"Blood"},{"key":"ref36","first-page":"555","article-title":"Pathology of dietary carbonyl iron overload in rats.","volume":"57","author":"CH Park","year":"1987","journal-title":"Lab Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0741-8329(03)00100-9","article-title":"Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease.","volume":"30","author":"S Xiong","year":"2003","journal-title":"Alcohol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"17646","DOI":"10.1074\/jbc.M210905200","article-title":"Signaling role of intracellular iron in NF-kappaB activation.","volume":"278","author":"S Xiong","year":"2003","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbagen.2008.08.006","article-title":"Iron metabolism in the anemia of chronic disease.","volume":"1790","author":"G Weiss","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1053\/jhep.2003.50196","article-title":"Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis.","volume":"37","author":"E Ueberham","year":"2003","journal-title":"Hepatology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1172\/JCI42011","article-title":"Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.","volume":"120","author":"I De Domenico","year":"2010","journal-title":"J Clin Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/hep.22716","article-title":"Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta\/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells.","volume":"49","author":"RG Ruddell","year":"2009","journal-title":"Hepatology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1073\/pnas.0409808102","article-title":"Regulation of hepcidin transcription by interleukin-1 and interleukin-6.","volume":"102","author":"P Lee","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/hep.510260311","article-title":"Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis.","volume":"26","author":"K Houglum","year":"1997","journal-title":"Hepatology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0168-8278(97)80424-2","article-title":"Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy.","volume":"26","author":"GA Ramm","year":"1997","journal-title":"J Hepatol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI114934","article-title":"Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload.","volume":"86","author":"K Houglum","year":"1990","journal-title":"J Clin Invest"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/0016-5085(94)90237-2","article-title":"Excess iron into hepatocytes is required for activation of collagen type I gene during experimental siderosis.","volume":"107","author":"R Gualdi","year":"1994","journal-title":"Gastroenterology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/hep.1840190325","article-title":"Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis.","volume":"19","author":"A Pietrangelo","year":"1994","journal-title":"Hepatology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/hep.1840110513","article-title":"Liver gene expression during chronic dietary iron overload in rats.","volume":"11","author":"A Pietrangelo","year":"1990","journal-title":"Hepatology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2362.2002.01026.x","article-title":"Long-term sequelae of HFE deletion in C57BL\/6 x 129\/O1a mice, an animal model for hereditary haemochromatosis.","volume":"32","author":"A Lebeau","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ab.2004.03.049","article-title":"Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells.","volume":"331","author":"J Riemer","year":"2004","journal-title":"Anal Biochem"},{"key":"ref52","first-page":"650","article-title":"Hepatic injury due to drugs, chemicals and toxins.","author":"JH Lewis","year":"2006"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2893.2005.00662.x","article-title":"Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C.","volume":"13","author":"G Sebastiani","year":"2006","journal-title":"J Viral Hepat"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e10163","DOI":"10.1371\/journal.pone.0010163","article-title":"Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.","volume":"5","author":"C Maffettone","year":"2010","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0025138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T23:01:04Z","timestamp":1540335664000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0025138"}},"subtitle":[],"editor":[{"given":"Young Nyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,22]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0025138","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,22]]}}}