{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:20:41Z","timestamp":1791418841908,"version":"4.3.3"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0025174","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T17:26:13Z","timestamp":1316453173000},"page":"e25174","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Aebp2 as an Epigenetic Regulator for Neural Crest Cells"],"prefix":"10.1371","volume":"6","author":[{"given":"Hana","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keunsoo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad B.","family":"Ekram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Young","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joomyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1093\/nar\/gkp149","article-title":"AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.","volume":"37","author":"H Kim","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14678","DOI":"10.1074\/jbc.274.21.14678","article-title":"Cloning and characterizing of a novel zinc finger transcriptional repressor.","volume":"274","author":"GP He","year":"1999","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2004.06.020","article-title":"Suz12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.","volume":"15","author":"R Cao","year":"2004","journal-title":"Mol Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.cell.2009.12.002","article-title":"Jarid2\/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.","volume":"139","author":"JC Peng","year":"2009","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.cell.2009.12.003","article-title":"Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.","volume":"139","author":"X Shen","year":"2009","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1101\/gad.1886410","article-title":"Jarid2 and PRC2, partners in regulating gene expression.","volume":"24","author":"G Li","year":"2010","journal-title":"Genes Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature08788","article-title":"JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.","volume":"464","author":"D Pasini","year":"2010","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1163045","article-title":"Polycomb proteins targeted by a short repeat RNA to the mouse\u00d7chromosome.","volume":"322","author":"J Zhao","year":"2008","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1242\/dev.033902","article-title":"Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice.","volume":"136","author":"B Schuettengruber","year":"2009","journal-title":"Development"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09784","article-title":"The Polycomb complex PRC2 and its mark in life.","volume":"469","author":"R Margueron","year":"2011","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1242\/dev.128.3.321","article-title":"<italic>Jing<\/italic>: a downstream target of <italic>slbo<\/italic> required for developmental control of border cell migration.","volume":"128","author":"Y Liu","year":"2001","journal-title":"Development"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/dvg.20436","article-title":"Evolution of the neural crest viewed from a gene regulatory perspective.","volume":"46","author":"T Sauka-Spengler","year":"2008","journal-title":"Genesis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrm2428","article-title":"A gene regulatory network orchestrates neural crest formation.","volume":"9","author":"T Sauka-Spengler","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1101\/sqb.2003.68.373","article-title":"Genomic variation in multigenic traits: Hirschsprung disease.","volume":"68","author":"AS McCallion","year":"2003","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review.","volume":"45","author":"J Amiel","year":"2008","journal-title":"J Med Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00383-009-2402-2","article-title":"Genetic basis of Hirschsprung&apos;s disease.","volume":"25","author":"PKH Tam","year":"2009","journal-title":"Pediatr Surg Int"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1034\/j.1600-0749.2003.00066.x","article-title":"Mouse models for four types of Waardenburg Syndrome.","volume":"16","author":"M Tachibana","year":"2003","journal-title":"Pigment Cell Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-0749.2004.00147.x","article-title":"Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders.","volume":"17","author":"LL Baxter","year":"2004","journal-title":"Pigment Cell Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/humu.21211","article-title":"Review and update of mutations causing Waardenburg syndrome.","volume":"31","author":"V Pingault","year":"2010","journal-title":"Hum Mutat"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0896-6273(00)80541-3","article-title":"GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.","volume":"21","author":"H Enomoto","year":"1998","journal-title":"Neuron"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ng998","article-title":"Genome-wide association study and mouse identify interaction between RET and EDNRB pathways in Hirschsprung disease.","volume":"32","author":"MM Carrasquillo","year":"2002","journal-title":"Nat Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1242\/dev.121.2.273","article-title":"The eed mutation disrupts anterior mesoderm production in mice.","volume":"121","author":"C Faust","year":"1995","journal-title":"Development"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/MCB.21.13.4330-4336.2001","article-title":"The polycomb-group gene Ezh2 is required for early mouse development.","volume":"21","author":"D O'Carroll","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1038\/sj.emboj.7600402","article-title":"Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.","volume":"23","author":"D Pasini","year":"2004","journal-title":"EMBO J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(92)90393-Q","article-title":"Isolation of a stem cell for neurons and glia from the mammalian neural crest.","volume":"71","author":"DL Stemple","year":"1992","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature04733","article-title":"Polycomb complexes repress developmental regulators in murine embryonic stem cells.","volume":"441","author":"LA Boyer","year":"2006","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cell.2006.02.043","article-title":"Control of developmental regulators by polycomb in human embryonic stem cells.","volume":"125","author":"TI Lee","year":"2006","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.cell.2008.04.043","article-title":"Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.","volume":"133","author":"X Chen","year":"2008","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.cell.2008.01.015","article-title":"Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.","volume":"132","author":"R Jaenisch","year":"2008","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/hmg\/ddi163","article-title":"Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease.","volume":"14","author":"SE Owens","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility.","volume":"8","author":"RL Jirtle","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/hdy.2010.2","article-title":"Environmental epigenetics.","volume":"105","author":"V Bollati","year":"2010","journal-title":"Heredity"},{"key":"ref33","first-page":"373","article-title":"Staining for \u03b2-galactosidase (lacZ) activity.","author":"B Hogan","year":"1994"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/hmg\/ddg028","article-title":"Methylation-sensitive binding of transcription factor YY1 to an insulator sequence within the paternally expressed imprinted gene, Peg3.","volume":"12","author":"J Kim","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abio.1999.4085","article-title":"Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro.","volume":"270","author":"J Winer","year":"1999","journal-title":"Anal Biochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0025174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T11:40:52Z","timestamp":1638704452000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0025174"}},"subtitle":[],"editor":[{"given":"Giacomo","family":"Cavalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,19]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0025174","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,19]]}}}