{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:27:08Z","timestamp":1791235628419,"version":"4.1.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0025261","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T21:05:48Z","timestamp":1317243948000},"page":"e25261","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Early Hypothalamic FTO Overexpression in Response to Maternal Obesity \u2013 Potential Contribution to Postweaning Hyperphagia"],"prefix":"10.1371","volume":"6","author":[{"given":"Vanni","family":"Caruso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret J.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(10)62037-5","article-title":"National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9\u00b71 million participants.","volume":"377","author":"MM Finucane","year":"2011","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(02)09678-2","article-title":"Childhood obesity: public-health crisis, common sense cure.","volume":"360","author":"CB Ebbeling","year":"2002","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/17477160600586747","article-title":"Worldwide trends in childhood overweight and obesity.","volume":"1","author":"Y Wang","year":"2006","journal-title":"Int J Pediatr Obes"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1038\/ijo.2009.16","article-title":"Genetics, physiology and perinatal influences in childhood obesity: view from the Chair.","volume":"33","author":"GA Mitchell","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"ref5","first-page":"952","article-title":"A global response to a global problem: the epidemic of overnutrition.","volume":"80","author":"M Chopra","year":"2002","journal-title":"Bull World Health Organ"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.nutr.012809.104747","article-title":"Physiological insights gained from gene expression analysis in obesity and diabetes.","volume":"30","author":"MP Keller","year":"2010","journal-title":"Annu Rev Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1038\/oby.2008.528","article-title":"Gene-environment interactions in the etiology of obesity: defining the fundamentals.","volume":"16","author":"C Bouchard","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.1095292","article-title":"Living with the past: evolution, development, and patterns of disease.","volume":"305","author":"PD Gluckman","year":"2004","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming.","volume":"85","author":"IC McMillen","year":"2005","journal-title":"Physiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1043-2760(02)00689-6","article-title":"Fetal programming of coronary heart disease.","volume":"13","author":"DJ Barker","year":"2002","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1586\/eem.09.45","article-title":"Early life influences on obesity risk \u2013 maternal overnutrition and programming of obesity.","volume":"4","author":"MJ Morris","year":"2009","journal-title":"Expert Opinion Endocrinology Metabolism"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ogc.2009.03.007","article-title":"Maternal and Child Obesity: The Causal Link.","volume":"36","author":"E Oken","year":"2009","journal-title":"Obstetrics and Gynecology Clinics of North America"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1210\/jc.2003-031046","article-title":"Obesity and pregnancy\u2013the propagation of a viscous cycle?","volume":"88","author":"PM Catalano","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng.325","article-title":"Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.","volume":"41","author":"X Yang","year":"2009","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.","volume":"316","author":"TM Frayling","year":"2007","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pgen.0030115","article-title":"Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits.","volume":"3","author":"A Scuteri","year":"2007","journal-title":"PLoS Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1471-2350-11-136","article-title":"Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children.","volume":"11","author":"H Fang","year":"2010","journal-title":"BMC Med Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1746","DOI":"10.1371\/journal.pone.0001746","article-title":"Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.","volume":"3","author":"SF Grant","year":"2008","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng2048","article-title":"Variation in FTO contributes to childhood obesity and severe adult obesity.","volume":"39","author":"C Dina","year":"2007","journal-title":"Nat Genet"},{"key":"ref20","article-title":"Association between the FTO gene and overweight in Japanese children and adolescents.","author":"M Okuda","year":"2011","journal-title":"Pediatr Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"E939","DOI":"10.1210\/jc.2010-2413","article-title":"Associations between a Single Nucleotide Polymorphism of the FTO Gene (rs9939609) and Obesity-Related Characteristics over Time during Puberty in a Dutch Children Cohort.","volume":"96","author":"F Rutters","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1210\/en.2007-1457","article-title":"The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain.","volume":"149","author":"R Fredriksson","year":"2008","journal-title":"Endocrinology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.1151710","article-title":"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.","volume":"318","author":"T Gerken","year":"2007","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMoa0803839","article-title":"An obesity-associated FTO gene variant and increased energy intake in children.","volume":"359","author":"JE Cecil","year":"2008","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/oby.2008.318","article-title":"Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure.","volume":"16","author":"JR Speakman","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ijo.2008.174","article-title":"The FTO gene and measured food intake in children.","volume":"33","author":"J Wardle","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e8771","DOI":"10.1371\/journal.pone.0008771","article-title":"Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.","volume":"5","author":"YC Tung","year":"2010","journal-title":"PLoS ONE"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1210\/en.2008-0582","article-title":"Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism.","volume":"149","author":"H Chen","year":"2008","journal-title":"Endocrinology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e6259","DOI":"10.1371\/journal.pone.0006259","article-title":"Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment.","volume":"4","author":"H Chen","year":"2009","journal-title":"PLoS ONE"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbrc.2010.08.133","article-title":"Relationship between blood glucose levels and hepatic Fto mRNA expression in mice.","volume":"400","author":"NJ Poritsanos","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/ng.713","article-title":"Overexpression of Fto leads to increased food intake and results in obesity.","volume":"42","author":"C Church","journal-title":"Nat Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e20158","DOI":"10.1371\/journal.pone.0020158","article-title":"Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly.","volume":"6","author":"JA Jacobsson","year":"2011","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/hmg\/ddp504","article-title":"Life course variations in the associations between FTO and MC4R gene variants and body size.","volume":"19","author":"R Hardy","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2337\/db10-1340","article-title":"FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life.","volume":"60","author":"JK Hertel","year":"2011","journal-title":"Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.2337\/db07-1466","article-title":"Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.","volume":"57","author":"RM Freathy","year":"2008","journal-title":"Diabetes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2350-9-59","article-title":"Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.","volume":"9","author":"DK Sanghera","year":"2008","journal-title":"BMC Med Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ijo.2008.213","article-title":"Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth.","volume":"33","author":"MJ Morris","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11695-008-9727-0","article-title":"The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients.","volume":"19","author":"C Zabena","year":"2009","journal-title":"Obes Surg"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2337\/db10-0281","article-title":"FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.","volume":"60","author":"A Bravard","year":"2011","journal-title":"Diabetes"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1471-0528.2006.00989.x","article-title":"The short- and long-term implications of maternal obesity on the mother and her offspring.","volume":"113","author":"PM Catalano","year":"2006","journal-title":"BJOG"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1210\/en.2009-1192","article-title":"A maternal \u201cjunk food&quot; diet in pregnancy and lactation promotes nonalcoholic Fatty liver disease in rat offspring.","volume":"151","author":"SA Bayol","year":"2010","journal-title":"Endocrinology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jhep.2009.12.042","article-title":"Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice.","volume":"52","author":"JA Oben","journal-title":"Journal of Hepatology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/hep.23205","article-title":"Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression.","volume":"50","author":"KD Bruce","year":"2009","journal-title":"Hepatology"},{"key":"ref45","first-page":"323","article-title":"Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.","volume":"119","author":"CE McCurdy","year":"2009","journal-title":"J Clin Invest"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0092-8674(05)80095-9","article-title":"SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.","volume":"75","author":"C Yokoyama","year":"1993","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1128\/MCB.13.8.4753","article-title":"ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.","volume":"13","author":"P Tontonoz","year":"1993","journal-title":"Mol Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"30339","DOI":"10.1074\/jbc.270.51.30339","article-title":"Hormonal and nutritional control of the fatty acid synthase promoter in transgenic mice.","volume":"270","author":"M Soncini","year":"1995","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0079-6603(08)60896-X","article-title":"Regulation of fat synthesis and adipose differentiation.","volume":"60","author":"HS Sul","year":"1998","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cbpb.2007.01.007","article-title":"Chicken liver and muscle carnitine palmitoyltransferase 1: nutritional regulation of messengers.","volume":"147","author":"S Skiba-Cassy","year":"2007","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.nut.2004.08.015","article-title":"Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats.","volume":"21","author":"MH Ryu","year":"2005","journal-title":"Nutrition"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1096\/fj.00-0717fje","article-title":"Hepatic mRNAs up-regulated by starvation: an expression profile determined by suppression subtractive hybridization.","volume":"15","author":"J Zhang","year":"2001","journal-title":"FASEB J"},{"issue":"Pt 2","key":"ref53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1042\/bj3000583","article-title":"Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat.","volume":"300","author":"S Thumelin","year":"1994","journal-title":"Biochem J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0025261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T17:42:56Z","timestamp":1560706976000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0025261"}},"subtitle":[],"editor":[{"given":"Rocio I.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,28]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0025261","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,28]]}}}