{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:26:26Z","timestamp":1793219186912,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T00:00:00Z","timestamp":1319673600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0025637","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T20:42:28Z","timestamp":1319748148000},"page":"e25637","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":369,"title":["The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis"],"prefix":"10.1371","volume":"6","author":[{"given":"Sabrina","family":"Cipriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mencarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Distrutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Renga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Baldelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annibale","family":"Donini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fiorucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.plipres.2009.11.001","article-title":"Bile acid-activated receptors in the treatment of dyslipidemia and related disorders.","volume":"49","author":"S Fiorucci","year":"2010","journal-title":"Prog Lipid Res"},{"key":"ref2","first-page":"579","article-title":"Counter-regulatory role of bile acid activated receptors in immunity and inflammation.","volume":"10","author":"S Fiorucci","year":"2010","journal-title":"Curr Mol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0006-291X(02)02550-0","article-title":"Identification of membrane-type receptor for bile acids (M-BAR).","volume":"298","author":"T Maruyama","year":"2002","journal-title":"Biochem Bophys Res Commun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids.","volume":"278","author":"Y Kawamata","year":"2003","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.","volume":"439","author":"M Watanabe","year":"2006","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1365-2982.2010.01487.x","article-title":"Expression and function of the bile acid receptor GP-BAR1 (TGR5) in the murine enteric nervous system.","volume":"22","author":"DP Poole","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbrc.2005.01.139","article-title":"Bile acids promote glucagon like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.","volume":"329","author":"S Katsuma","year":"2005","journal-title":"Biochem Biophis Res Comm"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbrc.2008.04.171","article-title":"Expression and function of the bile acid receptor TGR5 in Kupffer cells.","volume":"372","author":"V Keitel","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/BJ20060537","article-title":"Targeted deletion of GP-BAR1 protects mice from cholesterol gallstone formation.","volume":"398","author":"G Vassileva","year":"2006","journal-title":"Biochem J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"R1013","DOI":"10.1152\/ajpregu.2001.281.3.R1013","article-title":"Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice.","volume":"281","author":"Q Wang","year":"2001","journal-title":"J Physiol Regl Integr Comp Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1074-7613(02)00476-4","article-title":"Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.","volume":"17","author":"S Fiorucci","year":"2002","journal-title":"Immunity"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1053\/j.gastro.2005.01.051","article-title":"Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis.","volume":"128","author":"L Santucci","year":"2005","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.4049\/jimmunol.0803978","article-title":"The bile acid receptor FXR is a modulator of intestinal innate immunity.","volume":"183","author":"P Vavassori","year":"2009","journal-title":"J Immunol"},{"key":"ref14","first-page":"1","article-title":"Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.","volume":"20105","author":"JR Hov","year":"2010","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2007.06.130","article-title":"Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea.","volume":"362","author":"H Sato","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.","volume":"30","author":"GM Morris","year":"2009","journal-title":"Journal of Computational Chemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/jm7015864","article-title":"Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.","volume":"51","author":"H Sato","year":"2008","journal-title":"J Med Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1021\/jm070633p","article-title":"Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6, 23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.","volume":"50","author":"R Pellicciari","year":"2007","journal-title":"J Med Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","article-title":"Comparative protein structure modeling of genes and genomes.","volume":"29","author":"MA Marti-Renom","year":"2000","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints.","volume":"234","author":"A Sali","year":"1993","journal-title":"J Mol Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1006\/jmbi.1993.1351","article-title":"Main-chain bond lengths and bond angles in protein structures.","volume":"231","author":"RA Laskowski","year":"1993","journal-title":"J Mol Biol"},{"key":"ref22","first-page":"1646","article-title":"Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.","volume":"8","author":"DJ Drucker","year":"1994","journal-title":"Mol Endocrinol"},{"key":"ref23","first-page":"G906","article-title":"Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation.","volume":"294","author":"F Raimondi","year":"2008","journal-title":"Am J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/01635580701649644","article-title":"Effect of colonic bacterial metabolites on Caco-2 cell paracellular permeability in vitro.","volume":"60","author":"R Hughes","year":"2008","journal-title":"Nutr Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tips.2009.08.001","article-title":"Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders.","volume":"30","author":"S Fiorucci","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000111031","article-title":"Drug safety in Crohn&apos;s disease therapy.","volume":"76","author":"P Juillerat","year":"2007","journal-title":"Digestion"},{"key":"ref27","article-title":"Molecular mechanisms underlying bile acid stimulated glucagon-like peptide-1 secretion.","author":"HE Parker","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.","volume":"23","author":"A Mantovani","year":"2003","journal-title":"TRENDS Immunology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/ajg.2011.72","article-title":"Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis.","volume":"106","author":"KJ Khan","year":"2011","journal-title":"Am J Gastroenterol"}],"updated-by":[{"DOI":"10.1371\/annotation\/55febddb-0209-4a48-9c14-23df882126a2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0025637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T18:43:41Z","timestamp":1560883421000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0025637"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,10,27]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2011,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0025637","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/55febddb-0209-4a48-9c14-23df882126a2","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,27]]}}}