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Zomot","year":"2007","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/jcc.20933","article-title":"The generalized Born\/volume integral implicit solvent model: estimation of the free energy of hydration using London dispersion instead of atomic surface area.","volume":"29","author":"P Labute","year":"2008","journal-title":"J Comput Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures.","volume":"26","author":"R Laskowski","year":"1993","journal-title":"Journal of Applied Crystallography"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1124\/jpet.106.106583","article-title":"Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro.","volume":"319","author":"BK 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Mignot","year":"1994","journal-title":"Sleep"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1001\/jama.2009.351","article-title":"Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.","volume":"301","author":"ND Volkow","year":"2009","journal-title":"JAMA"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1038\/npp.2010.94","article-title":"Modafinil blocks reinstatement of extinguished opiate-seeking in rats: mediation by a glutamate mechanism.","volume":"35","author":"P Tahsili-Fahadan","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00213-002-1080-8","article-title":"Study of the addictive potential of modafinil in naive and cocaine-experienced rats.","volume":"161","author":"V Deroche-Gamonet","year":"2002","journal-title":"Psychopharmacology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF02247379","article-title":"Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil.","volume":"126","author":"LH Gold","year":"1996","journal-title":"Psychopharmacology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.pbb.2010.03.006","article-title":"Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.","volume":"95","author":"NE Paterson","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"ref77","article-title":"Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.","author":"R Wuo-Silva","year":"2011","journal-title":"Addict 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inhibitors.","volume":"329","author":"T Hiranita","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1124\/jpet.109.154302","article-title":"Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity.","volume":"330","author":"G Tanda","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2010.08.051","article-title":"The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization.","volume":"648","author":"AM Batman","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/jpet.105.090829","article-title":"Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs.","volume":"315","author":"VC Campbell","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1124\/jpet.105.084541","article-title":"Place conditioning and locomotor effects of N-substituted, 4\u2032,4\u2018\u2019-difluorobenztropine analogs in rats.","volume":"313","author":"S-M Li","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1523\/JNEUROSCI.4778-04.2005","article-title":"Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine.","volume":"25","author":"RI Desai","year":"2005","journal-title":"J Neurosci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/jpet.105.091231","article-title":"Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs.","volume":"315","author":"RI Desai","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/syn.20021","article-title":"Covalent and noncovalent chemical modifications of arginine residues decrease dopamine transporter activity.","volume":"52","author":"TJ Volz","year":"2004","journal-title":"Synapse"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1749-6632.2009.05145.x","article-title":"Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.","volume":"1187","author":"DV Herin","year":"2010","journal-title":"Ann NY Acad 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