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Hu","year":"2009","journal-title":"Biochemical Journal"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1073\/pnas.1103029108","article-title":"TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.","volume":"108","author":"FG Revel","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1110\/ps.0305603","article-title":"Construction of a sequence motif characteristic of aminergic G protein-coupled receptors.","volume":"12","author":"ES Huang","year":"2003","journal-title":"Protein Sci"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.chembiol.2008.03.004","article-title":"Toward deciphering the code to aminergic G protein-coupled receptor drug design.","volume":"15","author":"ES Tan","year":"2008","journal-title":"Chem 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Commun"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tips.2010.08.006","article-title":"The minor binding pocket: a major player in 7TM receptor activation.","volume":"31","author":"MM Rosenkilde","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/07435808409035410","article-title":"Molecular structure and biochemical activity of 3,5,3\u2032-triiodothyronamine.","volume":"10","author":"V Cody","year":"1984","journal-title":"Endocr Res"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1055\/s-2007-1018803","article-title":"Triiodothyronamine--a beta-adrenergic metabolite of triiodothyronine?","volume":"15","author":"T Meyer","year":"1983","journal-title":"Horm Metab Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1021\/jm0505718","article-title":"Trace Amine-Associated Receptor Agonists: Synthesis and Evaluation of Thyronamines and Related Analogues.","volume":"49","author":"ME Hart","year":"2006","journal-title":"Journal of Medicinal Chemistry"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1016\/j.bmcl.2009.08.058","article-title":"Amiodarone and its putative metabolites fail to activate wild type hTAAR1.","volume":"19","author":"AH Lewin","year":"2009","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1016\/j.bmcl.2008.08.013","article-title":"Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites.","volume":"18","author":"AN Snead","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"ref88","article-title":"Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773).","author":"H Stalder","year":"2011"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1021\/jm0700417","article-title":"Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.","volume":"50","author":"ES Tan","year":"2007","journal-title":"J Med Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1021\/cb800304d","article-title":"The Molecular Basis of Species-Specific Ligand Activation of Trace Amine-Associated Receptor 1 (TAAR1).","volume":"4","author":"ES Tan","year":"2009","journal-title":"ACS Chemical Biology"}],"container-title":["PLoS 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