{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:02:09Z","timestamp":1790521329802,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0027799","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T22:06:10Z","timestamp":1321913170000},"page":"e27799","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Generation of Immortal Cell Lines from the Adult Pituitary: Role of cAMP on Differentiation of SOX2-Expressing Progenitor Cells to Mature Gonadotropes"],"prefix":"10.1371","volume":"6","author":[{"given":"Ginah L.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep S.","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Koletar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise D.","family":"Belsham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2004.07.018","article-title":"Pituitary cell lines and their endocrine applications.","volume":"228","author":"GT Ooi","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1210\/en.2003-0946","article-title":"Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders.","volume":"145","author":"DD Belsham","year":"2004","journal-title":"Endocrinology"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1096\/fj.09-133454","article-title":"Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons.","author":"DD Belsham","year":"2009"},{"key":"ref4","first-page":"6","article-title":"Neuroendocrine gene regulation in hypothalamic cell lines.","volume":"3","author":"SS Dhillon","year":"2010","journal-title":"Open Neuroendocrin J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yfrne.2009.03.005","article-title":"Hypothalamic cell lines to investigate neuroendocrine control mechanisms.","volume":"30","author":"CM Mayer","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000100278","article-title":"Stem cells in the postnatal pituitary?","volume":"85","author":"H Vankelecom","year":"2007","journal-title":"Neuroendocrinology"},{"key":"ref7","article-title":"Stem cells in the pituitary gland: A burgeoning field.","author":"H Vankelecom","year":"2009"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1073\/pnas.0707886105","article-title":"SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.","volume":"105","author":"T Fauquier","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.cellbio.042308.113256","article-title":"Signaling in adult neurogenesis.","volume":"25","author":"H Suh","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/187152708783885174","article-title":"The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors.","volume":"7","author":"SD Skaper","year":"2008","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref11","article-title":"Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity.","author":"KK Cowansage","year":"2009"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1471-4159.2007.05018.x","article-title":"PACAP-38 induces neuronal differentiation of human SH-SY5Y neuroblastoma cells via cAMP-mediated activation of ERK and p38 MAP kinases.","volume":"104","author":"TK Monaghan","year":"2008","journal-title":"J Neurochem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1128\/MCB.02193-07","article-title":"Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation.","volume":"28","author":"GX Shi","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1124\/mol.107.044792","article-title":"A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells.","volume":"73","author":"A Ravni","year":"2008","journal-title":"Mol Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jneumeth.2009.11.004","article-title":"Differentiation of mouse Neuro 2A cells into dopamine neurons.","volume":"186","author":"RG Tremblay","year":"2010","journal-title":"J Neurosci Methods"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1089\/scd.2008.0412","article-title":"Neural stem\/progenitor cells differentiate in vitro to neurons by the combined action of dibutyryl cAMP and interferon-gamma.","volume":"18","author":"T Zahir","year":"2009","journal-title":"Stem Cells Dev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e4815","DOI":"10.1371\/journal.pone.0004815","article-title":"A GRFa2\/Prop1\/stem (GPS) cell niche in the pituitary.","volume":"4","author":"M Garcia-Lavandeira","year":"2009","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/j.1471-4159.1993.tb13404.x","article-title":"Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation.","volume":"60","author":"MK Howard","year":"1993","journal-title":"J Neurochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10571-008-9338-2","article-title":"Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation.","volume":"29","author":"S Obayashi","year":"2009","journal-title":"Cell Mol Neurobiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/elps.200600833","article-title":"Proteins involved in neuronal differentiation of neuroblastoma cell line N1E-115.","volume":"28","author":"JE Oh","year":"2007","journal-title":"Electrophoresis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5414\/NPP28309","article-title":"Evidence for a progenitor cell population in the human pituitary.","volume":"28","author":"S Weiss","year":"2009","journal-title":"Clin Neuropathol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/mcne.1996.0595","article-title":"The adult rat hippocampus contains primordial neural stem cells.","volume":"8","author":"TD Palmer","year":"1997","journal-title":"Mol Cell Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"16659","DOI":"10.1073\/pnas.0407643101","article-title":"Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells.","volume":"101","author":"J Hsieh","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","first-page":"439","article-title":"Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line.","volume":"10","author":"JL Turgeon","year":"1996","journal-title":"Mol Endocrinol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1242\/dev.122.10.3319","article-title":"Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice.","volume":"122","author":"ET Alarid","year":"1996","journal-title":"Development"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1210\/endo.137.7.8770922","article-title":"The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion.","volume":"137","author":"P Thomas","year":"1996","journal-title":"Endocrinology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1210\/mend-4-4-597","article-title":"Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice.","volume":"4","author":"JJ Windle","year":"1990","journal-title":"Mol Endocrinol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1210\/endo.142.6.8185","article-title":"Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model.","volume":"142","author":"F Pernasetti","year":"2001","journal-title":"Endocrinology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1073\/pnas.48.7.1184","article-title":"Hormone-producing cultures of adrenal and pituitary tumor origin.","volume":"48","author":"V Buonassisi","year":"1962","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3181\/00379727-84-20607","article-title":"ACTH secreting transplantable pituitary tumors.","volume":"84","author":"J Furth","year":"1953","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/endo-113-5-1587","article-title":"Mouse pituitary tumor line secreting only the a-subunit of the glycoprotein hormones: development from a thyrotropic tumor.","volume":"113","author":"EC Ridgway","year":"1983","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1530\/acta.0.1060459","article-title":"A new clonal strain of rat pituitary tumour cells: a model for non-regulated secretion of prolactin.","volume":"106","author":"MJ Reymond","year":"1984","journal-title":"Acta Endocrinologica"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1210\/endo-123-5-2341","article-title":"Characterization of the MMQ cell, a prolactin-secreting clonal cell line that is responsive to dopamine.","volume":"123","author":"AM Judd","year":"1988","journal-title":"Endocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.47.1.61","article-title":"Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells.","volume":"47","author":"AHJ Tashjian","year":"1970","journal-title":"J Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.bi.65.070196.003401","article-title":"Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells.","volume":"65","author":"A Jacobson","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.100883","article-title":"Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone.","volume":"202","author":"PE Belchetz","year":"1978","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1210\/edrv-11-1-177","article-title":"Molecular biology of the pituitary gonadotropins.","volume":"11","author":"SD Gharib","year":"1990","journal-title":"Endocrine Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2826.2005.01353.x","article-title":"Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes.","volume":"17","author":"JP Hapgood","year":"2005","journal-title":"J Neuroendocrinol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/endo.138.3.4968","article-title":"Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro.","volume":"138","author":"UB Kaiser","year":"1997","journal-title":"Endocrinology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/mend-4-4-557","article-title":"Divergent responses of gonadotropin subunit messenger RNAs to continuous <italic>versus<\/italic> pulsatile gonadotropin-releasing hormone <italic>in vitro<\/italic>.","volume":"4","author":"J Weiss","year":"1990","journal-title":"Mol Endo"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000094310","article-title":"Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and hormone resistance syndromes.","volume":"35","author":"J Drouin","year":"2006","journal-title":"Front Horm Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1399-0004.2007.00877.x","article-title":"Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.","volume":"72","author":"J Drouin","year":"2007","journal-title":"Clin Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1073\/pnas.0801644105","article-title":"Genetic approaches identify adult pituitary stem cells.","volume":"105","author":"AS Gleiberman","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1210\/en.2005-0185","article-title":"The adult pituitary contains a cell population displaying stem\/progenitor cell and early embryonic characteristics.","volume":"146","author":"J Chen","year":"2005","journal-title":"Endocrinology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1210\/en.2004-1209","article-title":"Nestin-immunoreactive cells in rat pituitary are neither hormonal nor typical folliculo-stellate cells.","volume":"146","author":"O Krylyshkina","year":"2005","journal-title":"Endocrinology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.yexcr.2005.04.023","article-title":"Identification and enrichment of colony-forming cells from the adult murine pituitary.","volume":"308","author":"DA Lepore","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1634\/stemcells.2006-0085","article-title":"A role for angiotensin-converting enzyme in the characterization, enrichment, and proliferation potential of adult murine pituitary colony-forming cells.","volume":"24","author":"DA Lepore","year":"2006","journal-title":"Stem Cells"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1634\/stemcells.2007-0012","article-title":"Survival and differentiation of pituitary colony-forming cells in vivo.","volume":"25","author":"DA Lepore","year":"2007","journal-title":"Stem Cells"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/stem.51","article-title":"Pituitary progenitor cells tracked down by side population dissection.","volume":"27","author":"J Chen","year":"2009","journal-title":"Stem Cells"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0027799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T23:02:27Z","timestamp":1713135747000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0027799"}},"subtitle":[],"editor":[{"given":"Manuel","family":"Tena-Sempere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0027799","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}