{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:21:31Z","timestamp":1791300091147,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0027883","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T22:05:24Z","timestamp":1321913124000},"page":"e27883","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione"],"prefix":"10.1371","volume":"6","author":[{"given":"Akiko","family":"Miyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hamakubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"ref1","first-page":"1044","article-title":"Parkinson&apos;s disease. First of two parts.","volume":"339","author":"AE Lang","year":"1998","journal-title":"New Eng J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00005072-199603000-00001","article-title":"Neuropathology of Parkinson&apos;s disease.","volume":"55","author":"LS Forno","year":"1996","journal-title":"J Neuropath Exp Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson&apos;s disease.","volume":"24","author":"H Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/tx700210j","article-title":"Oxidative stress and neurotoxicity.","volume":"21","author":"LM Sayre","year":"2008","journal-title":"Chem Res Tox"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/0002-9343(91)90281-2","article-title":"Oxidative stress: from basic research to clinical application.","volume":"91","author":"H Sies","year":"1991","journal-title":"Am J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn983","article-title":"Pathogenesis of Parkinson&apos;s disease: dopamine, vesicles and alpha-synuclein.","volume":"3","author":"J Lotharius","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","article-title":"Oxidative stress in Parkinson&apos;s disease.","volume":"53","author":"P Jenner","year":"2003","journal-title":"Ann Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0304-3940(82)90390-1","article-title":"Parkinson&apos;s disease: a disorder due to nigral glutathione deficiency?","volume":"33","author":"TL Perry","year":"1982","journal-title":"Neurosci Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.","volume":"299","author":"V Bonifati","year":"2003","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.embor.7400074","article-title":"DJ-1 has a role in antioxidative stress to prevent cell death.","volume":"5","author":"T Taira","year":"2004","journal-title":"EMBO Rep"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"37556","DOI":"10.1074\/jbc.M101730200","article-title":"DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.","volume":"276","author":"K Takahashi","year":"2001","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbrc.2003.11.056","article-title":"Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.","volume":"312","author":"T Yokota","year":"2003","journal-title":"Biochem Biophys Res Comm"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature09536","article-title":"Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.","volume":"468","author":"JN Guzman","year":"2010","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbrc.2004.03.110","article-title":"Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells.","volume":"317","author":"T Kinumi","year":"2004","journal-title":"Biochem Biophys Res Comm"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/10715760100300831","article-title":"Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat.","volume":"35","author":"A Mitsumoto","year":"2001","journal-title":"Free Radic Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2009.08.074","article-title":"Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients.","volume":"465","author":"Y Saito","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neulet.2010.08.007","article-title":"Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.","volume":"483","author":"YO Akazawa","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson&apos;s disease.","volume":"65","author":"D Blum","year":"2001","journal-title":"Prog Neurobiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/S0021-9258(19)42751-8","article-title":"The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.","volume":"249","author":"G Cohen","year":"1974","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/jnr.20382","article-title":"<italic>p<\/italic>-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.","volume":"79","author":"Y Izumi","year":"2005","journal-title":"J Neurosci Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.freeradbiomed.2006.12.004","article-title":"Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action.","volume":"42","author":"Y Saito","year":"2007","journal-title":"Free Rad Biol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s11745-003-1151-4","article-title":"Electrophile tocopheryl quinones in apoptosis and mutagenesis: thermochemolysis of thiol adducts with proteins and in cells.","volume":"38","author":"DG Cornwell","year":"2003","journal-title":"Lipids"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1021\/jm00214a026","article-title":"Isolation and identificaton of an in vivo reaction product of 6-hydroxydopamine.","volume":"20","author":"YO Liang","year":"1977","journal-title":"J Med Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0028-3908(02)00108-9","article-title":"Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells.","volume":"43","author":"E Shimizu","year":"2002","journal-title":"Neuropharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1046\/j.1471-4159.2000.0741605.x","article-title":"Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson&apos;s disease.","volume":"74","author":"R Soto-Otero","year":"2000","journal-title":"J Neurochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/10715760600632552","article-title":"Turning point in apoptosis\/necrosis induced by hydrogen peroxide.","volume":"40","author":"Y Saito","year":"2006","journal-title":"Free Radic Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0891-5849(89)90054-3","article-title":"Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions.","volume":"6","author":"P Gee","year":"1989","journal-title":"Free Rad Biol Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1073\/pnas.0510962103","article-title":"Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress.","volume":"103","author":"X Wang","year":"2006","journal-title":"Proc Nat Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0009-2797(88)90052-X","article-title":"Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes.","volume":"65","author":"TW Gant","year":"1988","journal-title":"Chem Biol Interact"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0891-5849(99)00177-X","article-title":"Glutathione and its role in cellular functions.","volume":"27","author":"H Sies","year":"1999","journal-title":"Free Rad Biol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.bbagen.2009.04.007","article-title":"Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme.","volume":"1790","author":"S Toppo","year":"2009","journal-title":"Biochim biophys Acta"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione transferases.","volume":"45","author":"JD Hayes","year":"2005","journal-title":"Ann Rev Pharmacol Toxicol"},{"issue":"44","key":"ref33","doi-asserted-by":"crossref","first-page":"43508","DOI":"10.1074\/jbc.M307075200","article-title":"Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.","volume":"278","author":"S Khanna","year":"2003","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1111\/j.1471-4159.2009.06550.x","article-title":"Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.","volume":"112","author":"S Khanna","year":"2010","journal-title":"J Neurochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"43150","DOI":"10.1074\/jbc.M507124200","article-title":"DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.","volume":"280","author":"W Zhou","year":"2005","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1074\/jbc.M806599200","article-title":"Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.","volume":"284","author":"J Blackinton","year":"2009","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/ars.2010.3481","article-title":"The role of cysteine oxidation in DJ-1 function and dysfunction.","volume":"15","author":"MA Wilson","journal-title":"Antioxid Redox Signal"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"24666","DOI":"10.1074\/jbc.M111.236273","article-title":"24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis.","volume":"286","author":"K Yamanaka","year":"2011","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.freeradbiomed.2010.08.016","article-title":"Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function.","volume":"49","author":"Y Saito","year":"2010","journal-title":"Free Rad Biol Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/10715760903536349","article-title":"Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: alteration of 58-kDa glucose-regulated protein and C\/EBP homologous protein.","volume":"44","author":"YO Akazawa","year":"2010","journal-title":"Free Radic Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides.","volume":"233","author":"PS Wolf","year":"1994","journal-title":"Methods Enzymol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"Determination of glutathione and glutathione disulfide in biological samples.","volume":"233","author":"ME Anderson","year":"1985","journal-title":"Methods Enzymol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0027883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T15:00:47Z","timestamp":1639753247000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0027883"}},"subtitle":[],"editor":[{"given":"Ashley I.","family":"Bush","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0027883","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}