{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:05Z","timestamp":1790517425023,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0027895","type":"journal-article","created":{"date-parts":[[2011,11,19]],"date-time":"2011-11-19T00:53:09Z","timestamp":1321663989000},"page":"e27895","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["Emergence and Transmission Pathways of Rapidly Evolving Evolutionary Branch C4a Strains of Human Enterovirus 71 in the Central Plain of China"],"prefix":"10.1371","volume":"6","author":[{"given":"Yong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanshen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingle","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiu","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,18]]},"reference":[{"key":"ref1","first-page":"757","article-title":"Family Picornaviridae.","author":"G Stanway","year":"2005"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1099\/vir.0.80475-0","article-title":"Enteroviruses 76, 89, 90 and 91 represent a novel group within the species Human enterovirus A. J Gen Virol","volume":"86","author":"MS Oberste","year":"2005","journal-title":"J Gen Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1099\/vir.0.79789-0","article-title":"Complete genome sequences of all members of the species Human enterovirus A. J Gen Virol","volume":"85","author":"MS Oberste","year":"2004","journal-title":"J Gen Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1743-422X-7-300","article-title":"Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008.","volume":"7","author":"Z Zhu","year":"2010","journal-title":"Virol J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JCM.43.8.3835-3839.2005","article-title":"Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China.","volume":"43","author":"L Li","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/00006454-199912000-00013","article-title":"Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998.","volume":"18","author":"LY Chang","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1651-2227.2003.tb02478.x","article-title":"Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases.","volume":"92","author":"CY Chong","year":"2003","journal-title":"Acta Paediatr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1086\/318454","article-title":"Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia.","volume":"32","author":"P McMinn","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.micinf.2010.03.006","article-title":"Neural pathogenesis of enterovirus 71 infection.","volume":"12","author":"KF Weng","year":"2010","journal-title":"Microbes Infect"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/520149","article-title":"Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications.","volume":"29","author":"SM Wang","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1016\/j.ijid.2010.07.006","article-title":"The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains.","volume":"14","author":"Y Wu","year":"2010","journal-title":"Int J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1128\/JCM.02369-09","article-title":"Clinical and etiological characteristics of enterovirus 71-related diseases during a recent 2-year period in Korea.","volume":"48","author":"WS Ryu","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1086\/511073","article-title":"Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study.","volume":"44","author":"MH Ooi","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/01.inf.0000227959.89339.c3","article-title":"Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003.","volume":"25","author":"M Hosoya","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005.","volume":"13","author":"PV Tu","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","article-title":"An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China.","volume":"44","author":"Y Zhang","year":"2009","journal-title":"J Clin Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1743-422X-7-94","article-title":"An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China.","volume":"7","author":"Y Zhang","year":"2010","journal-title":"Virol J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1097\/INF.0b013e3181e52945","article-title":"An investigation of epidemic enterovirus 71 infection in Taiwan, 2008: clinical, virologic, and serologic features.","volume":"29","author":"MS Lee","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.","volume":"341","author":"M Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998.","volume":"73","author":"BA Brown","year":"1999","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1442-200x.2004.01868.x","article-title":"Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region.","volume":"46","author":"H Shimizu","year":"2004","journal-title":"Pediatr Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/JCM.00563-09","article-title":"Enterovirus 71 outbreak in the People's Republic of China in 2008.","volume":"47","author":"F Yang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"ref23","first-page":"121","article-title":"Antigenic structure of picornaviruses.","volume":"161","author":"PD Minor","year":"1990","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","article-title":"Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification.","volume":"73","author":"MS Oberste","year":"1999","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcv.2011.03.006","article-title":"An automated genotyping tool for enteroviruses and noroviruses.","volume":"51","author":"A Kroneman","year":"2011","journal-title":"J Clin Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00705-003-0133-6","article-title":"Genetic analysis of the VP1 region of human enterovirus 71 strains isolated in Korea during 2000.","volume":"148","author":"YM Jee","year":"2003","journal-title":"Arch Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/JCM.02338-09","article-title":"Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China.","volume":"48","author":"Y Zhang","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.virusres.2008.07.015","article-title":"The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007.","volume":"137","author":"YP Huang","year":"2008","journal-title":"Virus Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.meegid.2009.05.010","article-title":"Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences.","volume":"10","author":"YF Chan","year":"2010","journal-title":"Infect Genet Evol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00705-010-0722-0","article-title":"Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71.","volume":"155","author":"CC Yip","year":"2010","journal-title":"Arch Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JCM.40.1.10-15.2002","article-title":"Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000.","volume":"40","author":"JR Wang","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jmv.20534","article-title":"Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71.","volume":"78","author":"KH Lin","year":"2006","journal-title":"J Med Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/00365548.2010.545995","article-title":"Molecular epidemiology of the 2005 enterovirus 71 outbreak in central Taiwan.","volume":"43","author":"YC Lan","year":"2011","journal-title":"Scand J Infect Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1743-422X-4-14","article-title":"Molecular epidemiology of measles viruses in China, 1995-2003.","volume":"4","author":"Y Zhang","year":"2007","journal-title":"Virol J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1128\/JCM.02055-09","article-title":"Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic.","volume":"48","author":"Z Zhu","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/rmv.538","article-title":"Genetic evolution of enterovirus 71: epidemiological and pathological implications.","volume":"17","author":"JM Bible","year":"2007","journal-title":"Rev Med Virol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1128\/JVI.01019-09","article-title":"Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene.","volume":"84","author":"KK Tee","year":"2010","journal-title":"J Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/biol.1993.1096","article-title":"Genetic basis of attenuation of the Sabin oral poliovirus vaccines.","volume":"21","author":"PD Minor","year":"1993","journal-title":"Biologicals"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1099\/vir.0.014258-0","article-title":"Characterization of a rare natural intertypic type 2\/type 3 penta-recombinant vaccine-derived poliovirus isolated from a child with acute flaccid paralysis.","volume":"91","author":"Y Zhang","year":"2010","journal-title":"J Gen Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/bib\/bbn017","article-title":"MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences.","volume":"9","author":"S Kumar","year":"2008","journal-title":"Brief Bioinform"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/JVI.73.1.152-160.1999","article-title":"Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination.","volume":"73","author":"KS Lole","year":"1999","journal-title":"J Virol"},{"key":"ref43","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT.","volume":"41","author":"TA Hall","year":"1999","journal-title":"Nucl Acids Symp"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2105-8-63","article-title":"Phylo-mLogo: an interactive and hierarchical multiple-logo visualization tool for alignment of many sequences.","volume":"8","author":"AC Shih","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"ref45","first-page":"543","article-title":"SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny.","volume":"12","author":"N Galtier","year":"1996","journal-title":"Comput Appl Biosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1471-2148-7-214","article-title":"BEAST: Bayesian evolutionary analysis by sampling trees.","volume":"7","author":"AJ Drummond","year":"2007","journal-title":"BMC Evol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1128\/JVI.77.15.8366-8377.2003","article-title":"Circulation of endemic type 2 vaccine-derived poliovirus in Egypt from 1983 to 1993.","volume":"77","author":"CF Yang","year":"2003","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0168-1702(92)90124-R","article-title":"Genotype-specific in vitro amplification of sequences of the wild type 3 polioviruses from Mexico and Guatemala.","volume":"24","author":"CF Yang","year":"1992","journal-title":"Virus Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0027895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T04:26:36Z","timestamp":1639715196000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0027895"}},"subtitle":[],"editor":[{"given":"Dong-Yan","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,18]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0027895","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,18]]}}}