{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:44:25Z","timestamp":1790318665680,"version":"4.1.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0027913","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T04:39:33Z","timestamp":1322714373000},"page":"e27913","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":65,"title":["Wheeze in Preschool Age Is Associated with Pulmonary Bacterial Infection and Resolves after Antibiotic Therapy"],"prefix":"10.1371","volume":"6","author":[{"given":"Nicolaus","family":"Schwerk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisharah","family":"Soudah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,29]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates.","volume":"332","author":"FD Martinez","year":"1995","journal-title":"N Engl J Med"},{"issue":"5","key":"ref2","first-page":"843","article-title":"Multicentre Allergy Study Group. Transient early wheeze is not associated with impaired lung function in 7-yr-old children.","volume":"21","author":"S Lau","year":"2003","journal-title":"Eur Respir J"},{"issue":"9537","key":"ref3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0140-6736(06)69286-6","article-title":"Wahn U. Multicentre Allergy Study (MAS) group. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study.","volume":"368","author":"S Illi","year":"2006","journal-title":"Lancet"},{"issue":"15","key":"ref4","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJMoa052632","article-title":"Childhood asthma after bacterial colonization of the airway in neonates.","volume":"357","author":"H Bisgaard","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"e8578","DOI":"10.1371\/journal.pone.0008578","article-title":"Disordered microbial communities in asthmatic airways.","volume":"5","author":"M Hilty","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1398-9995.2007.01586.x","article-title":"European Pediatric Asthma Group. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report.","volume":"63","author":"LB Bacharier","year":"2008","journal-title":"Allergy"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/ajrccm.160.1.9808096","article-title":"Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients.","volume":"160","author":"MS Muhlebach","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"ref8","article-title":"Atlas der BAL","author":"U Costabel","year":"1997"},{"issue":"9111","key":"ref9","first-page":"1225","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee.","volume":"351","year":"1998","journal-title":"Lancet"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ppul.20227","article-title":"Skin-prick testing as a diagnostic aid for childhood asthma.","volume":"39","author":"I Chan EY Dundas","year":"2005","journal-title":"Pediatr Pulmonol"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1183\/09031936.00002108","article-title":"Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach.","volume":"32","author":"PL Brand","year":"2008","journal-title":"Eur Respir J"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s00247-001-0654-7","article-title":"What can we learn from chest radiographs in hypoxemic asthmatics?","volume":"32","author":"SL Tsai","year":"2002","journal-title":"Pediatr Radiol"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1378\/chest.07-2779","article-title":"Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology.","volume":"134","author":"RS Aysola","year":"2008","journal-title":"Chest"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2214\/ajr.179.5.1791245","article-title":"Thoracic CT in pediatric patients with difficult-to-treat asthma.","volume":"179","author":"V Marchac","year":"2002","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/thx.2006.058933","article-title":"Outcomes in children treated for persistent bacterial bronchitis.","volume":"62","author":"D Donnelly","year":"2007","journal-title":"Thorax"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1183\/09031936.00.15121700","article-title":"Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society.","volume":"15","author":"J de Blic","year":"2000","journal-title":"Eur Respir J"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1378\/chest.122.3.791","article-title":"Bronchoalveolar cells in children &lt;3 years old with severe recurrent wheezing.","volume":"122","author":"M Le Bourgeois","year":"2002","journal-title":"Chest"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1086\/392498","article-title":"Mycoplasma pneumoniae and asthma in children.","volume":"38","author":"S Biscardi","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijantimicag.2006.11.029","article-title":"The role of antibiotics in asthma.","volume":"29","author":"F Blasi","year":"2007","journal-title":"Int J Antimicrob Agents"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/ppul.10266","article-title":"Differential cytology of bronchoalveolar lavage fluid in asthmatic children.","volume":"35","author":"N Najafi","year":"2003","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1183\/09031936.06.00030605","article-title":"Investigation of young children with severe recurrent wheeze: any clinical benefit?","volume":"27","author":"S Saglani","year":"2006","journal-title":"Eur Respir J"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5694\/j.1326-5377.2010.tb03504.x","article-title":"CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian cough guidelines summary statement.","volume":"192","author":"PG Gion","year":"2010","journal-title":"Med J Aust"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004822.pub2","article-title":"Antibiotics for prolonged moist cough in children.","volume":"19","author":"JM Marchant","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"c4978","DOI":"10.1136\/bmj.c4978","article-title":"Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.","volume":"341","author":"H Bisgaard","year":"2010","journal-title":"BMJ"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0027913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T17:18:13Z","timestamp":1741972693000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0027913"}},"subtitle":[],"editor":[{"given":"Dominik","family":"Hartl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,29]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0027913","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,29]]}}}