{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:37:09Z","timestamp":1782779829570,"version":"3.54.5"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0028085","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T04:40:36Z","timestamp":1322714436000},"page":"e28085","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Congenital Cataract Causing Mutants of \u03b1A-Crystallin\/sHSP Form Aggregates and Aggresomes Degraded through Ubiquitin-Proteasome Pathway"],"prefix":"10.1371","volume":"6","author":[{"given":"Ilangovan","family":"Raju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edathara C.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.survophthal.2004.02.013","article-title":"Molecular genetic basis of inherited cataract and associated phenotypes.","volume":"49","author":"MA Reddy","year":"2004","journal-title":"Sur Opthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0014-5793(75)80286-9","article-title":"The amino acid sequence of the A chain of human alpha-crystallin.","volume":"58","author":"WW De Jong","year":"1975","journal-title":"FEBS Lett"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1073\/pnas.89.21.10449","article-title":"Alpha-crystallin can function as a molecular chaperone.","volume":"89","author":"J Horwitz","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1167\/iovs.07-0013","article-title":"Genetic heterogeneity in microcornea-cataract: five novel mutations in CRYAA, CRYGD and GJA8.","volume":"48","author":"L Hansen","year":"2007","journal-title":"Invest Opthalmol Vis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1167\/iovs.06-0178","article-title":"Arginine 54 and Tyrosine 118 Residues of \u03b1A-Crystallin are Crucial for Lens Formation and Transparency.","volume":"47","author":"C Xia","year":"2006","journal-title":"Invest Opthalmol Vis Sci"},{"key":"ref6","first-page":"912","article-title":"Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P Graefes Arch Clin Exp Opthalmol","volume":"244","author":"J Graw","year":"2006"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/sj.ejhg.5201046","article-title":"Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q.","volume":"11","author":"DS Mackay","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"ref8","first-page":"768","article-title":"Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family.","volume":"12","author":"ST Santhiya","year":"2006","journal-title":"Mol Vis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/hmg\/7.3.471","article-title":"Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA.","volume":"7","author":"M Litt","year":"1998","journal-title":"Hum Mol Genet"},{"key":"ref10","first-page":"518","article-title":"A novel fan-shaped cataract-microcornea syndrome caused by a mutation of CRYAA in an Indian family.","volume":"12","author":"V Vanita","year":"2006","journal-title":"Mol Vis"},{"key":"ref11","article-title":"Structural, Functional And Hydrodynamic Properties of alphaA-crystallin Mutants Causing Congenital Cataracts.","volume":"D687","author":"RA Kore","year":"2010","journal-title":"ARVO Abstract 4617\/"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","article-title":"Aggresomes, inclusion bodies and protein aggregation.","volume":"10","author":"RR Kopito","year":"2000","journal-title":"Trends Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/hmg\/ddg074","article-title":"Aggresomes protects cells by enhancing the degradation of toxic-polyglutamine containing protein.","volume":"12","author":"JP Taylor","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(03)00939-5","article-title":"The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.","volume":"115","author":"Y Kawaguchi","year":"2003","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"47870","DOI":"10.1074\/jbc.M203159200","article-title":"Parkin Accumulation in Aggresomes Due to Proteasome Impairment.","volume":"277","author":"E Junn","year":"2002","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system.","volume":"67","author":"A Hershko","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrm1336","article-title":"Proteasomes and their kin: proteases in the machine age.","volume":"5","author":"CM Pickart","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2007.05.007","article-title":"Proteasomes: machine for all reasons.","volume":"129","author":"GN DeMartino","year":"2007","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e19876","DOI":"10.1371\/journal.pone.0019876","article-title":"Multiple Aggregates and Aggresomes of C-terminal truncated human \u03b1A-Crystallins in mammalian cells and Protection by \u03b1B-Crystallin.","volume":"6","author":"I Raju","year":"2011","journal-title":"PLoS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e3175","DOI":"10.1371\/journal.pone.0003175","article-title":"Interaction of C-terminal truncated human alphaA- crystallins with target proteins.","volume":"3","author":"A Kumarasamy","year":"2008","journal-title":"PLoS ONE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/ncb1830","article-title":"Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates.","volume":"11","author":"PH Ren","year":"2009","journal-title":"Nat Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/ncb2090","article-title":"Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition.","volume":"12","author":"A Luciani","year":"2010","journal-title":"Nat Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"40282","DOI":"10.1074\/jbc.M508786200","article-title":"HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.","volume":"280","author":"A Iwata","year":"2005","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.micro.57.030502.090836","article-title":"Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?","volume":"61","author":"T Wileman","year":"2007","journal-title":"Ann Rev Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1074\/jbc.M310994200","article-title":"Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.","volume":"279","author":"M Tanaka","year":"2004","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"25575","DOI":"10.1074\/jbc.M802216200","article-title":"Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin1.","volume":"283","author":"N Zaarur","year":"2008","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.","volume":"431","author":"M Arrasate","year":"2004","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/hmg\/ddg173","article-title":"Distinct chaperone mechanisms can delay formation of aggresomes by the myopathy-causing R120G alphaB-crystallin mutant.","volume":"12","author":"AT Chavez Zobel","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1167\/iovs.07-0196","article-title":"Degradation of C-terminal truncated alpha A-Crystallins by the ubiquitin-proteasome pathway.","volume":"48","author":"X Zhang","year":"2007","journal-title":"Invest Opthalmol Vis Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1016\/S0021-9258(18)53218-X","article-title":"The multicatalytic and 26S proteases.","volume":"268","author":"M Rechsteiner","year":"1993","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.yjmcc.2010.09.004","article-title":"Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways.","volume":"49","author":"H Zhang","year":"2010","journal-title":"J Mol Cell Cardio"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.","volume":"82","author":"MH Glickman","year":"2002","journal-title":"Physiol Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration.","volume":"443","author":"DC Rubinsztein","year":"2006","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0028085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T06:03:14Z","timestamp":1639807394000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0028085"}},"subtitle":[],"editor":[{"given":"Mark R.","family":"Cookson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,29]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0028085","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,29]]}}}