{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:49:01Z","timestamp":1785304141280,"version":"3.55.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T00:00:00Z","timestamp":1322438400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0028098","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T22:14:06Z","timestamp":1322518446000},"page":"e28098","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["dp53 Restrains Ectopic Neural Stem Cell Formation in the Drosophila Brain in a Non-Apoptotic Mechanism Involving Archipelago and Cyclin E"],"prefix":"10.1371","volume":"6","author":[{"given":"Yingshi","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbadis.2009.01.011","article-title":"Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm.","volume":"1792","author":"R Rahman","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1126\/science.1171837","article-title":"The increasing complexity of the cancer stem cell paradigm.","volume":"324","author":"JM Rosen","year":"2009","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrc2499","article-title":"Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.","volume":"8","author":"JE Visvader","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuron.2006.06.016","article-title":"Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology.","volume":"51","author":"F Yu","year":"2006","journal-title":"Neuron"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.03.004","article-title":"Connecting cancer to the asymmetric division of stem cells.","volume":"124","author":"A Wodarz","year":"2006","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1242\/dev.014977","article-title":"Neural stem cells: balancing self-renewal with differentiation.","volume":"135","author":"CQ Doe","year":"2008","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1038\/onc.2008.349","article-title":"Drosophila asymmetric division, polarity and cancer.","volume":"27","author":"J Januschke","year":"2008","journal-title":"Oncogene"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/ng1632","article-title":"Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster.","volume":"37","author":"E Caussinus","year":"2005","journal-title":"Nat Genet"},{"key":"ref9","first-page":"26","article-title":"NUMB-ing down cancer by more than just a NOTCH.","volume":"1815","author":"S Pece","year":"2011"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0092-8674(89)90849-0","article-title":"numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos.","volume":"58","author":"T Uemura","year":"1989","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature06056","article-title":"Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.","volume":"449","author":"H Wang","year":"2007","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0092-8674(94)90112-0","article-title":"Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.","volume":"76","author":"MS Rhyu","year":"1994","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.emboj.7601495","article-title":"aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.","volume":"26","author":"CA Smith","year":"2007","journal-title":"EMBO J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2008.07.049","article-title":"Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.","volume":"135","author":"F Wirtz-Peitz","year":"2008","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1242\/dev.058347","article-title":"Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.","volume":"138","author":"Y Ouyang","year":"2011","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/35059124","article-title":"cdc2 links the Drosophila cell cycle and asymmetric division machineries.","volume":"409","author":"M Tio","year":"2001","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1242\/dev.126.18.4027","article-title":"Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.","volume":"126","author":"P Casaccia-Bonnefil","year":"1999","journal-title":"Development"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1523\/JNEUROSCI.22-06-02255.2002","article-title":"Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis.","volume":"22","author":"F Doetsch","year":"2002","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.1272305","article-title":"p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity.","volume":"19","author":"TE Kippin","year":"2005","journal-title":"Genes Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.200703176","article-title":"The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.","volume":"178","author":"JL Vanderluit","year":"2007","journal-title":"J Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1083\/jcb.200403156","article-title":"p107 regulates neural precursor cells in the mammalian brain.","volume":"166","author":"JL Vanderluit","year":"2004","journal-title":"J Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1242\/dev.119.3.673","article-title":"A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis.","volume":"119","author":"HE Richardson","year":"1993","journal-title":"Development"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1126\/science.1388288","article-title":"Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.","volume":"257","author":"A Koff","year":"1992","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/0092-8674(91)90044-Y","article-title":"Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.","volume":"66","author":"A Koff","year":"1991","journal-title":"Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(94)90239-9","article-title":"Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.","volume":"77","author":"JA Knoblich","year":"1994","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cub.2010.11.049","article-title":"A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.","volume":"21","author":"S Ruiz","year":"2011","journal-title":"Curr Biol"},{"key":"ref27","article-title":"Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors.","author":"SM Hede","year":"2011"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrc2730","article-title":"The expanding universe of p53 targets.","volume":"9","author":"D Menendez","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/sj.onc.1201544","article-title":"Genetic instability leads to loss of both p53 alleles in a human glioblastoma.","volume":"16","author":"M Albertoni","year":"1998","journal-title":"Oncogene"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02639435","article-title":"Characterization of a new human glioblastoma cell line that expresses mutant p53 and lacks activation of the PDGF pathway.","volume":"31","author":"RA Gjerset","year":"1995","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1750-3639.1993.tb00749.x","article-title":"A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme.","volume":"3","author":"EW Newcomb","year":"1993","journal-title":"Brain Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1038\/sj.onc.1203740","article-title":"Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation.","volume":"19","author":"SY Leung","year":"2000","journal-title":"Oncogene"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1242\/dev.02208","article-title":"p53 suppresses the self-renewal of adult neural stem cells.","volume":"133","author":"K Meletis","year":"2006","journal-title":"Development"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1523\/JNEUROSCI.3970-05.2006","article-title":"Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.","volume":"26","author":"S Gil-Perotin","year":"2006","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nature07443","article-title":"p53 and Pten control neural and glioma stem\/progenitor cell renewal and differentiation.","volume":"455","author":"H Zheng","year":"2008","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature06412","article-title":"NUMB controls p53 tumour suppressor activity.","volume":"451","author":"IN Colaluca","year":"2008","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35095076","article-title":"Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.","volume":"413","author":"H Strohmaier","year":"2001","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/35095068","article-title":"Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.","volume":"413","author":"KH Moberg","year":"2001","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.1065203","article-title":"Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.","volume":"294","author":"DM Koepp","year":"2001","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0092-8674(00)80626-1","article-title":"Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.","volume":"101","author":"M Ollmann","year":"2000","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1073\/pnas.97.13.7301","article-title":"Identification and characterization of a p53 homologue in Drosophila melanogaster.","volume":"97","author":"S Jin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0092-8674(00)80627-3","article-title":"Drosophila p53 binds a damage response element at the reaper locus.","volume":"101","author":"MH Brodsky","year":"2000","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1038\/sj.onc.1203113","article-title":"Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc.","volume":"18","author":"M Yamaguchi","year":"1999","journal-title":"Oncogene"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/cdd.2009.182","article-title":"Dual roles of Drosophila p53 in cell death and cell differentiation.","volume":"17","author":"Y Fan","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1101\/gad.1743709","article-title":"Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.","volume":"23","author":"CA Fasano","year":"2009","journal-title":"Gene Dev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/nature08311","article-title":"Linking the p53 tumour suppressor pathway to somatic cell reprogramming.","volume":"460","author":"T Kawamura","year":"2009","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nature08235","article-title":"Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.","volume":"460","author":"H Hong","year":"2009","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0092-8674(00)81818-8","article-title":"Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.","volume":"87","author":"ME Lane","year":"1996","journal-title":"Cell"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0092-8674(00)81819-X","article-title":"A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis.","volume":"87","author":"JC de Nooij","year":"1996","journal-title":"Cell"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/4601085a","article-title":"Stem cells: The promises and perils of p53.","volume":"460","author":"V Krizhanovsky","year":"2009","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200912024","article-title":"Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system.","volume":"188","author":"S Mandal","year":"2010","journal-title":"J Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.cub.2004.04.040","article-title":"The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.","volume":"14","author":"KH Moberg","year":"2004","journal-title":"Curr Biol:"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2005.11.006","article-title":"Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila.","volume":"9","author":"S Mandal","year":"2005","journal-title":"Dev Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1185640","article-title":"Meiotic recombination provokes functional activation of the p53 regulatory network.","volume":"328","author":"WJ Lu","year":"2010","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e1000566","DOI":"10.1371\/journal.pbio.1000566","article-title":"A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila.","volume":"8","author":"D Mesquita","year":"2010","journal-title":"PLoS Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.cub.2006.07.046","article-title":"Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity.","volume":"16","author":"BS Wells","year":"2006","journal-title":"Curr Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1083\/jcb.200910006","article-title":"A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.","volume":"189","author":"LA Buttitta","year":"2010","journal-title":"J Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e1000594","DOI":"10.1371\/journal.pgen.1000594","article-title":"Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage.","volume":"5","author":"F Simon","year":"2009","journal-title":"PLoS Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ydbio.2009.11.012","article-title":"Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function.","volume":"337","author":"C Berger","year":"2010","journal-title":"Dev Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1242\/jcs.00825","article-title":"An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis.","volume":"116","author":"F Calegari","year":"2003","journal-title":"J Cell Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.cellbio.042308.113248","article-title":"Mechanisms of stem cell self-renewal.","volume":"25","author":"S He","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrc2290","article-title":"FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.","volume":"8","author":"M Welcker","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2006.03.011","article-title":"Stem cells and cancer: two faces of eve.","volume":"124","author":"MF Clarke","year":"2006","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.devcel.2008.03.004","article-title":"The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.","volume":"14","author":"SK Bowman","year":"2008","journal-title":"Dev Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.devcel.2009.12.007","article-title":"dFezf\/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.","volume":"18","author":"M Weng","year":"2010","journal-title":"Dev Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.cub.2005.07.061","article-title":"Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila.","volume":"15","author":"S Bhalerao","year":"2005","journal-title":"Curr Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ydbio.2007.10.002","article-title":"The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system.","volume":"312","author":"NT Mortimer","year":"2007","journal-title":"Dev Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0028098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T03:24:22Z","timestamp":1639797862000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0028098"}},"subtitle":[],"editor":[{"given":"Amit","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,28]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0028098","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,28]]}}}