{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:50:09Z","timestamp":1789912209405,"version":"4.0.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0028537","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T20:16:24Z","timestamp":1323893784000},"page":"e28537","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Missense Mutation in the Second RNA Binding Domain Reveals a Role for Prkra (PACT\/RAX) during Skull Development"],"prefix":"10.1371","volume":"6","author":[{"given":"Benjamin K.","family":"Dickerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Nalesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Fouch\u00e9court","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Guillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Viriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganes C.","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"H\u00e9rault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1093\/emboj\/17.15.4379","article-title":"PACT, a protein activator of the interferon-induced protein kinase, PKR.","volume":"17","author":"RC Patel","year":"1998","journal-title":"EMBO J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"15427","DOI":"10.1074\/jbc.274.22.15427","article-title":"RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling.","volume":"274","author":"T Ito","year":"1999","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11754","DOI":"10.1074\/jbc.M011400200","article-title":"Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.","volume":"276","author":"PP Ruvolo","year":"2001","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"37993","DOI":"10.1074\/jbc.M004762200","article-title":"PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.","volume":"275","author":"CV Patel","year":"2000","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1042\/bst0300886","article-title":"Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes.","volume":"30","author":"SJ Gilbert","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"15909","DOI":"10.1074\/jbc.M600612200","article-title":"Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons.","volume":"281","author":"G Chen","year":"2006","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/MCB.21.6.1908-1920.2001","article-title":"Modular structure of PACT: distinct domains for binding and activating PKR.","volume":"21","author":"GA Peters","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1182\/blood-2005-11-006817","article-title":"RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection.","volume":"108","author":"RL Bennett","year":"2006","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1016\/j.febslet.2007.08.001","article-title":"The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis.","volume":"581","author":"ES Lee","year":"2007","journal-title":"FEBS Lett"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jmb.2008.10.068","article-title":"Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis.","volume":"385","author":"M Singh","year":"2009","journal-title":"J Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/j.1460-2075.1992.tb05200.x","article-title":"Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.","volume":"11","author":"KL Chong","year":"1992","journal-title":"Embo J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"20823","DOI":"10.1016\/S0021-9258(19)30005-5","article-title":"Protein phosphorylation controls translation rates.","volume":"264","author":"JW Hershey","year":"1989","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0888-7543(95)80110-8","article-title":"Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).","volume":"25","author":"CA Kozak","year":"1995","journal-title":"Genomics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1073\/pnas.91.11.4713","article-title":"TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.","volume":"91","author":"H Park","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1128\/MCB.16.6.3023","article-title":"A testis cytoplasmic RNA-binding protein that has the properties of a translational repressor.","volume":"16","author":"K Lee","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0042-6822(03)00589-0","article-title":"The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity.","volume":"315","author":"V Gupta","year":"2003","journal-title":"Virology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4161\/rna.5.2.6069","article-title":"Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.","volume":"5","author":"G Laraki","year":"2008","journal-title":"RNA Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"35129","DOI":"10.1074\/jbc.M607714200","article-title":"Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis.","volume":"281","author":"GA Peters","year":"2006","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"42687","DOI":"10.1074\/jbc.M403321200","article-title":"Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition.","volume":"279","author":"RL Bennett","year":"2004","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/MCB.01030-08","article-title":"TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.","volume":"29","author":"A Daher","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1021\/bi200104h","article-title":"Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation.","volume":"50","author":"M Singh","year":"2011","journal-title":"Biochemistry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1073\/pnas.0602317103","article-title":"Molecular basis for PKR activation by PACT or dsRNA.","volume":"103","author":"S Li","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj20020204","article-title":"The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).","volume":"366","author":"X Huang","year":"2002","journal-title":"Biochem J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1002\/j.1460-2075.1995.tb00300.x","article-title":"Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.","volume":"14","author":"YL Yang","year":"1995","journal-title":"EMBO J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1073\/pnas.0601287103","article-title":"A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing.","volume":"103","author":"TM Rowe","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1073\/pnas.0900735106","article-title":"The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation.","volume":"106","author":"GA Peters","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/sj.emboj.7600942","article-title":"The role of PACT in the RNA silencing pathway.","volume":"25","author":"Y Lee","year":"2006","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development.","volume":"35","author":"E Bernstein","year":"2003","journal-title":"Nat Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI33680","article-title":"Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.","volume":"118","author":"M Otsuka","year":"2008","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ydbio.2008.11.011","article-title":"Sertoli cell Dicer is essential for spermatogenesis in mice.","volume":"326","author":"MD Papaioannou","year":"2009","journal-title":"Dev Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(08)70022-X","article-title":"DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.","volume":"7","author":"S Camargos","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S1474-4422(08)70075-9","article-title":"A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient.","volume":"7","author":"P Seibler","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/78146","article-title":"Genome-wide, large-scale production of mutant mice by ENU mutagenesis.","volume":"25","author":"MH Hrabe de Angelis","year":"2000","journal-title":"Nat Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1042\/BC20040525","article-title":"Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1.","volume":"97","author":"V Besson","year":"2005","journal-title":"Biol Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-213X-7-81","article-title":"KIT is required for hepatic function during mouse post-natal development.","volume":"7","author":"L Magnol","year":"2007","journal-title":"BMC Dev Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.mod.2008.06.009","article-title":"RAX is required for fly neuronal development and mouse embryogenesis.","volume":"125","author":"RL Bennett","year":"2008","journal-title":"Mech Dev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"17649","DOI":"10.1074\/jbc.M611768200","article-title":"Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.","volume":"282","author":"KH Kok","year":"2007","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ydbio.2010.01.039","article-title":"Dicer is required for survival of differentiating neural crest cells.","volume":"340","author":"A Zehir","year":"2010","journal-title":"Dev Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.0021-8782.2004.00356.x","article-title":"Craniofacial variability and morphological integration in mice susceptible to cleft lip and palate.","volume":"205","author":"B Hallgrimsson","year":"2004","journal-title":"J Anat"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1128\/JVI.76.21.11054-11064.2002","article-title":"Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.","volume":"76","author":"GA Peters","year":"2002","journal-title":"J Virol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0028537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T09:57:58Z","timestamp":1639994278000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0028537"}},"subtitle":[],"editor":[{"given":"Karen L.","family":"Mossman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,14]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0028537","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,14]]}}}