{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:44:40Z","timestamp":1773758680100,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T00:00:00Z","timestamp":1323043200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0028598","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T21:59:19Z","timestamp":1323122359000},"page":"e28598","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study"],"prefix":"10.1371","volume":"6","author":[{"given":"Chloe Y. Y.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette W. K.","family":"Tso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard M. Y.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol H. Y.","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence S. C.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson M. S.","family":"Wat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Janus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pak C.","family":"Sham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S. L.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11154-010-9144-2","article-title":"Pancreatic beta-cell K(ATP) channels: Hypoglycaemia and hyperglycaemia.","volume":"11","author":"K Bennett","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s001250051098","article-title":"Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2\/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.","volume":"41","author":"EH Hani","year":"1998","journal-title":"Diabetologia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2337\/diabetes.52.2.568","article-title":"Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.","volume":"52","author":"AL Gloyn","year":"2003","journal-title":"Diabetes"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.2337\/db09-1386","article-title":"Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.","volume":"59","author":"G Chauhan","year":"2010","journal-title":"Diabetes"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e7643","DOI":"10.1371\/journal.pone.0007643","article-title":"PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.","volume":"4","author":"C Hu","year":"2009","journal-title":"PLoS ONE"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/jhg.2009.54","article-title":"The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population.","volume":"54","author":"D Zhou","year":"2009","journal-title":"J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2337\/diabetes.51.3.875","article-title":"K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.","volume":"51","author":"C Schwanstecher","year":"2002","journal-title":"Diabetes"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2337\/dc07-1157","article-title":"KCNJ11 E23K affects diabetes risk and is associated with the disposition index: results of two independent German cohorts.","volume":"31","author":"A Fischer","year":"2008","journal-title":"Diabetes Care"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.609","article-title":"Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.","volume":"42","author":"BF Voight","year":"2010","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","article-title":"Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.","volume":"316","author":"R Saxena","year":"2007","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1142364","article-title":"Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.","volume":"316","author":"E Zeggini","year":"2007","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.2337\/db06-1709","article-title":"Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study.","volume":"56","author":"Y Doi","year":"2007","journal-title":"Diabetes"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.2337\/db07-0615","article-title":"Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.","volume":"57","author":"M Vaxillaire","year":"2008","journal-title":"Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1464-5491.2007.02255.x","article-title":"Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women.","volume":"24","author":"L Qi","year":"2007","journal-title":"Diabet Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2337\/db06-0966","article-title":"Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.","volume":"56","author":"JC Florez","year":"2007","journal-title":"Diabetes"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1210\/jc.2004-1204","article-title":"Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.","volume":"89","author":"O Laukkanen","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e14022","DOI":"10.1371\/journal.pone.0014022","article-title":"Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.","volume":"5","author":"M Xu","year":"2010","journal-title":"PLoS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1440-1681.1997.tb02736.x","article-title":"Epidemiology of cardiovascular risk factors in Hong Kong.","volume":"24","author":"ED Janus","year":"1997","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.2337\/dc06-1820","article-title":"Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study.","volume":"30","author":"BM Cheung","year":"2007","journal-title":"Diabetes Care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.","volume":"15","author":"KG Alberti","year":"1998","journal-title":"Diabet Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.1371\/journal.pmed.0020345","article-title":"Genetic prediction of future type 2 diabetes.","volume":"2","author":"V Lyssenko","year":"2005","journal-title":"PLoS Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.2337\/db08-0425","article-title":"Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.","volume":"57","author":"M van Hoek","year":"2008","journal-title":"Diabetes"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI7231","article-title":"The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus.","volume":"104","author":"C Weyer","year":"1999","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00592-008-0056-5","article-title":"Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.","volume":"46","author":"DA Chistiakov","year":"2009","journal-title":"Acta Diabetol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1464-5491.2006.02050.x","article-title":"Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population.","volume":"24","author":"BK Koo","year":"2007","journal-title":"Diabet Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0028598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:04:43Z","timestamp":1588971883000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0028598"}},"subtitle":[],"editor":[{"given":"Giorgio","family":"Sesti","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,5]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0028598","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,5]]}}}