{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:14:18Z","timestamp":1770484458130,"version":"3.49.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0028717","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T15:19:22Z","timestamp":1323875962000},"page":"e28717","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ursodeoxycholic Acid Is Conjugated with Taurine to Promote Secretin-Stimulated Biliary Hydrocholeresis in the Normal Rat"],"prefix":"10.1371","volume":"6","author":[{"given":"Miriam","family":"\u00dariz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"S\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas M.","family":"Banales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.3748\/wjg.v12.i22.3496","article-title":"Cholangiocyte anion exchange and biliary bicarbonate excretion.","volume":"12","author":"JM Banales","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"G612","DOI":"10.1152\/ajpgi.2001.281.3.G612","article-title":"Regulation of cholangiocyte bicarbonate secretion.","volume":"281","author":"N Kanno","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/hep.21042","article-title":"Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger.","volume":"43","author":"JM Banales","year":"2006","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"20413","DOI":"10.1074\/jbc.M302108200","article-title":"Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes.","volume":"278","author":"PS Tietz","year":"2003","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jhep.2009.11.027","article-title":"Primary biliary cirrhosis: a 2010 update.","volume":"52","author":"R Poupon","year":"2010","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ncpgasthep0521","article-title":"Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis.","volume":"3","author":"U Beuers","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2009.04.009","article-title":"EASL Clinical Practice Guidelines: management of cholestatic liver diseases.","volume":"51","year":"2009","journal-title":"J Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1056\/NEJMct074694","article-title":"Ursodeoxycholic acid for the treatment of primary biliary cirrhosis.","volume":"357","author":"K Lindor","year":"2007","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/hep.23810","article-title":"The biliary HCO<sub>3<\/sub><sup>\u2212<\/sup> umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies.","volume":"52","author":"U Beuers","year":"2010","journal-title":"Hepatology"},{"key":"ref10","article-title":"A biliary HCO<sub>3<\/sub><sup>\u2212<\/sup> umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.","author":"S Hohenester","year":"2011","journal-title":"Hepatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0016-5085(99)70564-0","article-title":"Assessment of biliary bicarbonate secretion in humans by positron emission tomography.","volume":"117","author":"J Prieto","year":"1999","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/hep.510250104","article-title":"Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis.","volume":"25","author":"JF Medina","year":"1997","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0016-5085(93)90735-U","article-title":"Abnormal expression of anion exchanger genes in primary biliary cirrhosis.","volume":"105","author":"J Prieto","year":"1993","journal-title":"Gastroenterology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/hep.23709","article-title":"Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat.","volume":"52","author":"CM Rodr\u00edguez-Ortigosa","year":"2010","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/0006-2952(91)90515-7","article-title":"Biliary excretion of polyethylene glycol molecular weight 900. Evidence for a bile salt-stimulated vesicular transport mechanism.","volume":"42","author":"MG Roma","year":"1991","journal-title":"Biochem Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/hep.23403","article-title":"Bicarbonate secretion of mouse cholangiocytes involves Na<sup>+<\/sup>-HCO<sub>3<\/sub><sup>\u2212<\/sup> cotransport in addition to Na<sup>+<\/sup>-independent Cl<sup>\u2212<\/sup>\/HCO<sub>3<\/sub><sup>\u2212<\/sup> exchange.","volume":"51","author":"I Uriarte","year":"2010","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2353\/ajpath.2008.080125","article-title":"Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.","volume":"173","author":"JM Banales","year":"2008","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/hep.22636","article-title":"The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).","volume":"49","author":"JM Banales","year":"2009","journal-title":"Hepatology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI107233","article-title":"Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man.","volume":"52","author":"RD Soloway","year":"1973","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/gut.2007.140871","article-title":"Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC\u00e1-\/PKA-dependent mechanism in rat liver.","volume":"57","author":"R Wimmer","year":"2008","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1139\/o69-133","article-title":"Secretion of bile salts by intact and isolated rat livers.","volume":"47","author":"MT Subbiah","year":"1969","journal-title":"Can J Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1002\/hep.23954","article-title":"Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation.","volume":"52","author":"KP Rembacz","year":"2010","journal-title":"Hepatology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.23911","article-title":"Conjugation is essential for the anticholestatic effect of <italic>nor<\/italic>ursodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.","volume":"52","author":"GU Denk","year":"2010","journal-title":"Hepatology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.hepres.2005.09.029","article-title":"Hepatoprotective bile acid \u2018ursodeoxycholic acid (UDCA)\u2019 Property and difference as bile acids.","volume":"33","author":"K Ishizaki","year":"2005","journal-title":"Hepatol Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/hep.1840200434","article-title":"Tubulovesicular transport of horseradish peroxidase in isolated rat hepatocyte couplets: effects of low temperature, cytochalasin B and bile acids.","volume":"20","author":"S Sakisaka","year":"1994","journal-title":"Hepatology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/gast.2001.26262","article-title":"Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats.","volume":"121","author":"AK Kurz","year":"2001","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/hep.20653","article-title":"Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats.","volume":"41","author":"G Alpini","year":"2005","journal-title":"Hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2353\/ajpath.2010.090677","article-title":"After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.","volume":"176","author":"R Mancinelli","year":"2010","journal-title":"Am J Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2353\/ajpath.2006.050126","article-title":"Ca<sup>2+<\/sup>-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts.","volume":"168","author":"M Marzioni","year":"2006","journal-title":"Am J Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3580001","article-title":"Stimulation of ATP secretion in the liver by therapeutic bile acids.","volume":"358","author":"MH Nathanson","year":"2001","journal-title":"Biochem J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1053\/j.gastro.2007.08.071","article-title":"Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.","volume":"133","author":"R Fiorotto","year":"2007","journal-title":"Gastroenterology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2007.08.020","article-title":"Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile.","volume":"133","author":"N Minagawa","year":"2007","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/hep.510290220","article-title":"Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis.","volume":"29","author":"P Invernizzi","year":"1999","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/gut.38.3.439","article-title":"Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis.","volume":"38","author":"KDR Setchell","year":"1996","journal-title":"Gut"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/jn\/105.9.1206","article-title":"Metabolism of [<sup>35<\/sup>S]taurine in man.","volume":"105","author":"JA Sturman","year":"1975","journal-title":"J Nutr"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/0016-5085(90)90032-V","article-title":"Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis.","volume":"98","author":"M Podda","year":"1990","journal-title":"Gastroenterology"},{"key":"ref37","article-title":"The potential usefulness of taurine on diabetes mellitus and its complications.","author":"T Ito","year":"2011","journal-title":"Amino Acids"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0028717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:39:40Z","timestamp":1588959580000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0028717"}},"subtitle":[],"editor":[{"given":"Thierry","family":"Tordjmann","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,14]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0028717","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,14]]}}}