{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:35:37Z","timestamp":1791171337026,"version":"4.1.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0029020","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T21:54:46Z","timestamp":1324504486000},"page":"e29020","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Intratumoral Injection of Propionibacterium acnes Suppresses Malignant Melanoma by Enhancing Th1 Immune Responses"],"prefix":"10.1371","volume":"6","author":[{"given":"Kenshiro","family":"Tsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Linan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Akeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kakeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/357545a0","article-title":"Tumours and Coley&apos;s toxins.","volume":"357","author":"G Rook","year":"1992","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1096-9098(199806)68:2<79::AID-JSO3>3.0.CO;2-H","article-title":"Pulsing of dendritic cells with cell lysates from either B16 melanoma or MCA-106 fibrosarcoma yields equally effective vaccines against B16 tumors in mice.","volume":"68","author":"P DeMatos","year":"1998","journal-title":"Journal of surgical oncology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1593\/neo.101628","article-title":"NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model.","volume":"13","author":"S Morello","year":"2011","journal-title":"Neoplasia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1593\/tlo.10250","article-title":"Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development.","volume":"4","author":"JA Scutti","year":"2011","journal-title":"Translational oncology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2009.00890.x","article-title":"New developments in our understanding of acne pathogenesis and treatment.","volume":"18","author":"I Kurokawa","year":"2009","journal-title":"Exp Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-0625.2010.01180.x","article-title":"Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitis.","volume":"20","author":"H Kitagawa","year":"2011","journal-title":"Experimental Dermatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2567.2004.01925.x","article-title":"The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both?","volume":"112","author":"S Romagnani","year":"2004","journal-title":"Immunology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.4049\/jimmunol.159.8.3961","article-title":"IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.","volume":"159","author":"H Tsutsui","year":"1997","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jdermsci.2009.02.015","article-title":"Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease.","volume":"55","author":"H Sugisaki","year":"2009","journal-title":"J Dermatol Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm.2078","article-title":"Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.","volume":"16","author":"L Liu","year":"2010","journal-title":"Nature medicine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jaci.2009.06.020","article-title":"Induction of IL-10-producing regulatory T cells with TCR diversity by epitope-specific immunotherapy in pollinosis.","volume":"124","author":"K Yamanaka","year":"2009","journal-title":"The Journal of allergy and clinical immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00280-010-1326-9","article-title":"Pharmacokinetic\/pharmacodynamic analysis of adjuvant pegylated interferon alpha-2b in patients with resected high-risk melanoma.","volume":"67","author":"AI Daud","year":"2011","journal-title":"Cancer chemotherapy and pharmacology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1200\/JCO.1991.9.7.1151","article-title":"Corynebacterium parvum versus bacille Calmette-Guerin adjuvant immunotherapy of stage II malignant melanoma.","volume":"9","author":"A Lipton","year":"1991","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/ijc.2910490526","article-title":"Modulation of tumoricidal activity, induced in bone-marrow-derived mononuclear phagocytes by interferon gamma or Corynebacterium parvum, by interferon beta, tumor necrosis factor, prostaglandin E2, and transforming growth factor beta.","volume":"49","author":"R Keller","year":"1991","journal-title":"International journal of cancer Journal international du cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1365-3083.2007.01939.x","article-title":"Modulatory effect of killed Propionibacterium acnes and its purified soluble polysaccharide on peritoneal exudate cells from C57Bl\/6 mice: major NKT cell recruitment and increased cytotoxicity.","volume":"65","author":"RZ Ananias","year":"2007","journal-title":"Scandinavian journal of immunology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1084\/jem.178.4.1223","article-title":"Antitumor and antimetastatic activity of interleukin 12 against murine tumors.","volume":"178","author":"MJ Brunda","year":"1993","journal-title":"The Journal of experimental medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1359-6101(01)00032-6","article-title":"Interleukin-12 in anti-tumor immunity and immunotherapy.","volume":"13","author":"MP Colombo","year":"2002","journal-title":"Cytokine & growth factor reviews"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/eji.1830250133","article-title":"Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist.","volume":"25","author":"S Gillessen","year":"1995","journal-title":"European journal of immunology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.169.3.1535","article-title":"Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.","volume":"169","author":"J Kim","year":"2002","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1200\/JCO.2007.15.6794","article-title":"Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma.","volume":"26","author":"AI Daud","year":"2008","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.193.1.35","article-title":"Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease.","volume":"193","author":"H Yoneyama","year":"2001","journal-title":"The Journal of experimental medicine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.imbio.2005.10.013","article-title":"In vivo and in vitro effect of killed Propionibacterium acnes and its purified soluble polysaccharide on mouse bone marrow stem cells and dendritic cell differentiation.","volume":"211","author":"CC Squaiella","year":"2006","journal-title":"Immunobiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jaci.2007.01.022","article-title":"Mechanisms of allergen-specific immunotherapy.","volume":"119","author":"M Akdis","year":"2007","journal-title":"The Journal of allergy and clinical immunology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1073\/pnas.0601554103","article-title":"Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells.","volume":"103","author":"H Liu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1172\/JCI25947","article-title":"Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.","volume":"115","author":"J Dannull","year":"2005","journal-title":"The Journal of clinical investigation"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0029020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T01:50:29Z","timestamp":1686534629000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0029020"}},"subtitle":[],"editor":[{"given":"George","family":"Kassiotis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,21]]},"references-count":25,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0029020","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,21]]}}}