{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:46:27Z","timestamp":1779896787382,"version":"3.53.1"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0029353","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T21:47:46Z","timestamp":1327009666000},"page":"e29353","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of Akt Activity and Calcium Channel Function Coordinately Drive Cell-Cell Fusion in the BeWO Choriocarcinoma Placental Cell Line"],"prefix":"10.1371","volume":"7","author":[{"given":"Manu","family":"Vatish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Tesfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Grammatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire C.","family":"Bastie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Pessin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2818.2009.03302.x","article-title":"Time-lapse imaging of in vitro myogenesis using atomic force microscopy.","volume":"237","author":"B Stadler","year":"2010","journal-title":"Journal of microscopy"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.devcel.2007.01.016","article-title":"WIP\/WASp-based actin-polymerization machinery is essential for myoblast fusion in Drosophila.","volume":"12","author":"R Massarwa","year":"2007","journal-title":"Developmental cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/ENDO:19:1:3","article-title":"Hormones and human trophoblast differentiation: a review.","volume":"19","author":"A Malassine","year":"2002","journal-title":"Endocrine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1053\/plac.2001.0648","article-title":"Key regulatory transcription factors involved in placental trophoblast development\u2013a review.","volume":"22","author":"M Knofler","year":"2001","journal-title":"Placenta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1126\/science.1104799","article-title":"Unveiling the mechanisms of cell-cell fusion.","volume":"308","author":"EH Chen","year":"2005","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.micron.2005.12.011","article-title":"Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion.","volume":"37","author":"B Huppertz","year":"2006","journal-title":"Micron"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-59745-250-2_8","article-title":"Placenta trophoblast fusion.","volume":"475","author":"B Huppertz","year":"2008","journal-title":"Methods in molecular biology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1128\/MCB.23.10.3566-3574.2003","article-title":"Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation.","volume":"23","author":"JL Frendo","year":"2003","journal-title":"Molecular and cellular biology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00430-003-0191-0","article-title":"The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation.","volume":"193","author":"K Mori","year":"2004","journal-title":"Medical microbiology and immunology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2003.040550","article-title":"Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells.","volume":"550","author":"Y Kudo","year":"2003","journal-title":"The Journal of physiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.bbrc.2003.12.183","article-title":"ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase.","volume":"314","author":"N Ito","year":"2004","journal-title":"Biochemical and biophysical research communications"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0143-4004(05)80259-0","article-title":"Modulation of phosphatidylserine epitope expression by BeWo cells during forskolin treatment.","volume":"14","author":"TW Lyden","year":"1993","journal-title":"Placenta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s004180050311","article-title":"Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta.","volume":"110","author":"B Huppertz","year":"1998","journal-title":"Histochemistry and cell biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0167-4889(03)00004-1","article-title":"Quantifying the syncytialisation of human placental trophoblast BeWo cells grown in vitro.","volume":"1640","author":"Y Kudo","year":"2003","journal-title":"Biochimica et biophysica acta"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0143-4004(03)00173-5","article-title":"A two-colour fluorescence assay for the measurement of syncytial fusion between trophoblast-derived cell lines.","volume":"24","author":"M Borges","year":"2003","journal-title":"Placenta"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cyto.1171","article-title":"Doublet discrimination in DNA cell-cycle analysis.","volume":"46","author":"RP Wersto","year":"2001","journal-title":"Cytometry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/jcs.28.1.167","article-title":"A fluorescence enhancement assay of cell fusion.","volume":"28","author":"PM Keller","year":"1977","journal-title":"J Cell Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1677\/JOE-07-0097","article-title":"Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.","volume":"194","author":"E Hirsch","year":"2007","journal-title":"The Journal of endocrinology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"12545","DOI":"10.1016\/S0021-9258(18)42311-3","article-title":"Thapsigargin inhibits contraction and Ca2+ transient in cardiac cells by specific inhibition of the sarcoplasmic reticulum Ca2+ pump.","volume":"267","author":"MS Kirby","year":"1992","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1387\/ijdb.082765md","article-title":"Placental nutrient supply and fetal growth.","volume":"54","author":"M Desforges","year":"2010","journal-title":"The International journal of developmental biology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.placenta.2006.05.009","article-title":"The mitotic manipulation of cytotrophoblast differentiation in vitro.","volume":"28","author":"IP Crocker","year":"2007","journal-title":"Placenta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia.","volume":"5","author":"BC Young","year":"2010","journal-title":"Annual review of pathology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jcp.20679","article-title":"Calcium sources used by post-natal human myoblasts during initial differentiation.","volume":"208","author":"S Arnaudeau","year":"2006","journal-title":"Journal of cellular physiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.placenta.2008.02.013","article-title":"Morphological and electrical properties of human trophoblast choriocarcinoma, BeWo cells.","volume":"29","author":"AJ Ramos","year":"2008","journal-title":"Placenta"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1677\/JOE-10-0027","article-title":"Role of extracellular signal-regulated kinase and AKT cascades in regulating hypoxia-induced angiogenic factors produced by a trophoblast-derived cell line.","volume":"206","author":"D Fujita","year":"2010","journal-title":"The Journal of endocrinology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0029353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T12:49:34Z","timestamp":1640522974000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0029353"}},"subtitle":[],"editor":[{"given":"Mikhail V.","family":"Blagosklonny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0029353","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}