{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:59:47Z","timestamp":1787320787055,"version":"build-2736575974"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0029442","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T16:56:10Z","timestamp":1327078570000},"page":"e29442","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Curcumin-Arteether Combination Therapy of Plasmodium berghei-Infected Mice Prevents Recrudescence Through Immunomodulation"],"prefix":"10.1371","volume":"7","author":[{"given":"Palakkod G.","family":"Vathsala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitanya","family":"Dende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanathan Arun","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debapriya","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobardhan","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pundi N.","family":"Rangarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindarajan","family":"Padmanaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4269\/ajtmh.2004.71.179","article-title":"Antimalarial drug resistance artemisinin-based combination therapy and the contribution of modeling to elucidating policy choices.","volume":"71","author":"S Yeung","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1098\/rstb.1999.0426","article-title":"Antimalarial drug resistance and combination therapy.","volume":"354","author":"NJ White","year":"1999","journal-title":"Phil Trans R Soc Lond B Biol Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin Resistance in <italic>Plasmodium falciparum<\/italic> Malaria.","volume":"361","author":"AM Dondorp","year":"2009","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4269\/ajtmh.2007.77.181","article-title":"Artemisinin-based combination treatment of falciparum malaria.","volume":"77","author":"F Nosten","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1371\/journal.pctr.0020020","article-title":"Artemether-lumefantrine versus dihydroartemisinin-piperaqine for treatment of malaria: a randomized trial.","volume":"2","author":"MR Kamya","year":"2007","journal-title":"PLoS Clin Trials"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.trstmh.2006.01.001","article-title":"Safety and efficacy of dihydroaretmisinin\/piperaquine (Artekin), for the treatment of uncomplicated <italic>Plasmodium falciparum<\/italic> malaria in Rwanden children.","volume":"101","author":"C Karema","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bbrc.2004.11.051","article-title":"Curcumin for malaria therapy.","volume":"326","author":"RC Reddy","year":"2006","journal-title":"Biochem Biophys Res Comm"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/AAC.50.5.1859-1860.2006","article-title":"Curcumin - artemisinin combination therapy for malaria.","volume":"50","author":"DN Nanadakumar","year":"2006","journal-title":"Antimicrob Agents Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1128\/JCM.42.12.5636-5643.2004","article-title":"Detection of four Plasmodium species from humans by 18S rRNA gene subunit -based and species -specific real time PCR assays.","volume":"42","author":"M Rougemont","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.exppara.2008.02.011","article-title":"<italic>Plasmodium chabaudi<\/italic>: Efficacy of artemisinin+curcumin combination treatment on a clone selected for artemisinin resistance in mice.","volume":"119","author":"A Martinelli","year":"2008","journal-title":"Exp Parasitol"},{"key":"ref11","article-title":"Oral delivery of curcumin bound to chitosan nanoparticles cured <italic>Plasmodium yoelli<\/italic> infected mice.","author":"F Akhtar","year":"2011","journal-title":"Biotech Adv BA-06408"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1051\/parasite\/1999064311","article-title":"Survival of rodent malaria merozoites in the lymphatic network: Potential role in chronicity of the infection.","volume":"6","author":"I Landau","year":"1999","journal-title":"Parasite"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1073\/pnas.1108579108","article-title":"Rodent blood-stage <italic>Plasmodium<\/italic> survive in dendrtic cells that infect na\u00efve mice.","volume":"108","author":"MN Wykes","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"40629","DOI":"10.1074\/jbc.M407308200","article-title":"Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.","volume":"279","author":"Y Song","year":"2004","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ab.2004.10.037","article-title":"Detection and quantitation of curcumin in mouse lung cell cultures by matrix-assisted laser desorption ionization time of flight mass spectrometry.","volume":"337","author":"LA May","year":"2004","journal-title":"Anal Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4269\/ajtmh.2000.62.73","article-title":"Effects of Artesunate, Dihydroartemisinin, and an Artesunate-Dihydroartemisinin combination against <italic>Toxoplasma gondii.<\/italic>","volume":"62","author":"ME Sarciron","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408690490424702","article-title":"Biological properties of curcumin-cellular and molecular mechanisms of action.","volume":"44","author":"B Joe","year":"2004","journal-title":"Crit Rev Food Sci Nutri"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/AAC.01238-06","article-title":"Cytotoxic effect of curcumin on malaria parasite <italic>Plasmodium falciparum<\/italic>. Inhibition of histone acetylation and generation of reactive oxygen species.","volume":"51","author":"L Cui","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8606","DOI":"10.1074\/jbc.M413541200","article-title":"Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of <italic>Plasmodium falciparum<\/italic>: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity.","volume":"280","author":"G Krishnegowda","year":"2005","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.0608745104","article-title":"Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.","volume":"104","author":"P Parroche","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1073\/pnas.0809742106","article-title":"Malaria primes the innate immune response due to interferon-\u03b3 induced enhancement of toll-like receptor expression and function.","volume":"106","author":"BS Franklin","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1056\/NEJM198906153202404","article-title":"Tumor necrosis factor and disease severity in children with falciparum malaria.","volume":"320","author":"GE Grau","year":"1989","journal-title":"N Engl J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1086\/508547","article-title":"Increased levels of inflammatory mediators in children with severe <italic>Plasmodium falciparum<\/italic> malaria with respiratory distress.","volume":"194","author":"GA Awandare","year":"2006","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1128\/IAI.01783-06","article-title":"CD4<sup>+<\/sup> CD25<sup>+<\/sup> Regulatory T cells suppress CD4<sup>+<\/sup> T-Cell function and inhibit the development of <italic>Plasmodium berghei<\/italic> - specific TH1 responses involved in cerebral malaria pathogenesis.","volume":"75","author":"CQ Nie","year":"2007","journal-title":"Infect Immun"},{"key":"ref25","first-page":"35","article-title":"Regulating immunity to malaria Parasite.","volume":"28","author":"EM Riley","year":"2006","journal-title":"Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00436-009-1435-8","article-title":"CD4<sup>+<\/sup> T cell response in early erythrocytic stage malaria: Plasmodium berghei infection in BALB\/c and C57BL\/6 mice.","volume":"105","author":"A Shibui","year":"2009","journal-title":"Parasitol Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.4049\/jimmunol.168.3.1348","article-title":"IL-12 is required for antibody-mediated protective immunity against blood stage <italic>Plasmodium chabaudi<\/italic> HS malarial infection in mice.","volume":"168","author":"Z Su","year":"2002","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.exppara.2007.01.007","article-title":"<italic>Plasmodium Yoelii<\/italic>: Influence of antimalarial agent on acquision of immunity in BALB\/C and DBA\/2 mice.","volume":"116","author":"s-h Ma","year":"2007","journal-title":"Exptl Parasitol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells.","volume":"10","author":"M Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpara.2009.08.009","article-title":"IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites.","volume":"40","author":"M Niikura","year":"2010","journal-title":"Int J Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s004360000366","article-title":"Immune-mediated parasite clearance in mice infected with <italic>Plasmodium berghei<\/italic> treatment with manzamine A.","volume":"87","author":"KKH Ang","year":"2001","journal-title":"Parasitol Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/IAI.00982-08","article-title":"Secreted antibody is required for immunity to <italic>Plasmodium berghei.<\/italic>","volume":"77","author":"JK Nunes","year":"2009","journal-title":"Infect Immunity"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1567205053585882","article-title":"A potential role of the curry spice curcumin in Alzheimer&apos;s disease.","volume":"2","author":"JM Ringman","year":"2005","journal-title":"Curr Alzheimer Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1093941","article-title":"Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.","volume":"304","author":"ME Egan","year":"2004","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10875-006-9066-7","article-title":"\u201cSpicing up\u201d the immune system by curcumin.","volume":"27","author":"GC Jagetia","year":"2007","journal-title":"J Clin Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pt.2009.12.005","article-title":"Targeting the hypnozoite reservoir of <italic>Plasmodium vivax<\/italic>: the hidden obstacle to malaria elimination.","volume":"26","author":"TN Wells","year":"2010","journal-title":"Trends Parasitol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.exppara.2010.01.005","article-title":"Modulation of cerebral malaria by fasudil and other immune-modifying compounds.","volume":"125","author":"JH Waknine-Grinberg","year":"2010","journal-title":"Exp Parasitol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"S10 1","DOI":"10.1186\/1475-2875-10-S1-S10","article-title":"The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria.","volume":"10","author":"PN Mimche","year":"2011","journal-title":"Malaria J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ab.2003.10.016","article-title":"Spectrophotometric determination of de novo hemozoin\/beta-hematin formation in an in vitro assay.","volume":"325","author":"AK Tripathi","journal-title":"Anal Biochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0029442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:45:03Z","timestamp":1589003103000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0029442"}},"subtitle":[],"editor":[{"given":"Thomas J.","family":"Templeton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,20]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0029442","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,20]]}}}