{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:43:12Z","timestamp":1772818992586,"version":"3.50.1"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0029503","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T21:53:52Z","timestamp":1325195632000},"page":"e29503","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inflammatory-Induced Hibernation in the Fetus: Priming of Fetal Sheep Metabolism Correlates with Developmental Brain Injury"],"prefix":"10.1371","volume":"6","author":[{"given":"Matthias","family":"Keller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Enot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Hodson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeka I.","family":"Igwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Peter","family":"Deigner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Dean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayde","family":"Bolouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2471\/BLT.08.062554","article-title":"The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity.","volume":"88","author":"S Beck","year":"2010","journal-title":"Bull World Health Organ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa041367","article-title":"Neurologic and developmental disability at six years of age after extremely preterm birth.","volume":"352","author":"N Marlow","year":"2005","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e891","DOI":"10.1542\/peds.2009-0313","article-title":"Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study.","volume":"125","author":"K Mestan","year":"2010","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/0883073809338066","article-title":"Fetal inflammatory response and brain injury in the preterm newborn.","volume":"24","author":"S Malaeb","year":"2009","journal-title":"J Child Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MOP.0b013e3283423e6b","article-title":"The new bronchopulmonary dysplasia.","volume":"23","author":"AH Jobe","year":"2011","journal-title":"Curr Opin Pediatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1177\/0883073809338068","article-title":"White matter damage after chronic subclinical inflammation in newborn mice.","volume":"24","author":"X Wang","year":"2009","journal-title":"J Child Neurol"},{"key":"ref7","first-page":"n\/a","article-title":"Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep.","author":"JM Dean","year":"2011","journal-title":"Ann Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between mitochondrial dysfunction and severity and outcome of septic shock.","volume":"360","author":"D Brealey","year":"2002","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ng.507","article-title":"A genome-wide perspective of genetic variation in human metabolism.","volume":"42","author":"T Illig","year":"2010","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI44442","article-title":"Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.","volume":"121","author":"EP Rhee","year":"2011","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI34138","article-title":"Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the cns of siv-infected macaques.","volume":"118","author":"WR Wikoff","year":"2008","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/978-1-61779-027-0_16","article-title":"Bioinformatics for mass spectrometry-based metabolomics.","volume":"719","author":"DP Enot","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e13953","DOI":"10.1371\/journal.pone.0013953","article-title":"Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting.","volume":"5","author":"K Suhre","year":"2010","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2990.1979.tb00664.x","article-title":"Foetal brain development in the sheep.","volume":"5","author":"GH McIntosh","year":"1979","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/cne.901350302","article-title":"The foetal sheep: morphogenesis of the nervous system and histochemical aspects of myelination.","volume":"135","author":"RM Barlow","year":"1969","journal-title":"J Comp Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1348-0421.2000.tb02581.x","article-title":"Lipopolysaccharide (lps)-induced intrauterine fetal death (iufd) in mice is principally due to maternal cause but not fetal sensitivity to lps.","volume":"44","author":"Y Kohmura","year":"2000","journal-title":"Microbiol Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1177\/1933719109335801","article-title":"Increased maternal\/fetal blood s100 b levels following systemic endotoxin administration and periventricular white matter injury in preterm fetal sheep.","volume":"16","author":"Y Garnier","year":"2009","journal-title":"Reprod Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1203\/00006450-200212000-00021","article-title":"White matter injury after repeated endotoxin exposure in the preterm ovine fetus.","volume":"52","author":"JR Duncan","year":"2002","journal-title":"Pediatr Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0143-4004(03)00104-8","article-title":"The effects of repeated endotoxin exposure on placental structure in sheep.","volume":"24","author":"JR Duncan","year":"2003","journal-title":"Placenta"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.ajog.2004.07.009","article-title":"Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis.","volume":"191","author":"YM Kim","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.placenta.2004.12.012","article-title":"Expression and subcellular localization of tlr-4 in term and first trimester human placenta.","volume":"27","author":"ECE Beijar","year":"2006","journal-title":"Placenta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/MCO.0b013e328333aa4f","article-title":"Recent advances in our understanding of protein and amino acid metabolism in the human fetus.","volume":"13","author":"CHV den Akker","year":"2010","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref23","first-page":"509","article-title":"Fetal requirements and placental transfer of nitrogenous compounds.","author":"WW Hay","year":"2007"},{"key":"ref24","first-page":"E538","article-title":"Metabolic and circulatory studies of fetal lamb at midgestation.","volume":"250","author":"AW Bell","year":"1986","journal-title":"Am J Physiol"},{"key":"ref25","first-page":"E299","article-title":"Uteroplacental carbon substrate metabolism and o2 consumption after long-term hypoglycemia in pregnant sheep.","volume":"269","author":"TD Carver","year":"1995","journal-title":"Am J Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.placenta.2010.09.002","article-title":"Nf<italic>\u03ba<\/italic>b-dependent increase of kynurenine pathway activity in human placenta: inhibition by sulfasalazine.","volume":"31","author":"PDN Ligam","year":"2010","journal-title":"Placenta"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/00003246-199307000-00015","article-title":"Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock.","volume":"21","author":"G Kreymann","year":"1993","journal-title":"Crit Care Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00024382-199608000-00002","article-title":"Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: effects on plasma lactate.","volume":"6","author":"TC Vary","year":"1996","journal-title":"Shock"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S441","DOI":"10.1097\/01.CCM.0000278049.48333.78","article-title":"Mitochondrial function in sepsis: acute phase versus multiple organ failure.","volume":"35","author":"M Singer","year":"2007","journal-title":"Crit Care Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1096\/fj.04-2842fje","article-title":"Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis.","volume":"19","author":"RA Claus","year":"2005","journal-title":"FASEB J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20102049","article-title":"Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in tnfr1-associated periodic syndrome (traps).","volume":"208","author":"AC Bulua","year":"2011","journal-title":"J Exp Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0065-2423(07)00007-8","article-title":"Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach.","volume":"45","author":"A Gonz\u00e1lez","year":"2008","journal-title":"Adv Clin Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/j.1471-4159.2008.05241.x","article-title":"Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity.","volume":"105","author":"R Owe-Young","year":"2008","journal-title":"J Neurochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-2999(81)90587-2","article-title":"Quinolinic acid: a potent endogenous excitant at amino acid receptors in cns.","volume":"72","author":"TW Stone","year":"1981","journal-title":"Eur J Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0301-0082(00)00032-0","article-title":"Kynurenines in the cns: from endogenous obscurity to therapeutic importance.","volume":"64","author":"TW Stone","year":"2001","journal-title":"Prog Neurobiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.6849138","article-title":"Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.","volume":"219","author":"R Schwarcz","year":"1983","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0006-291X(02)02917-0","article-title":"Electrochemical and in vitro evaluation of the redox-properties of kynurenine species.","volume":"300","author":"GI Giles","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1161\/01.ATV.0000013312.32196.49","article-title":"Oxysterols: friends, foes, or just fellow passengers?","volume":"22","author":"I Bj\u00f6rkhem","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"30178","DOI":"10.1074\/jbc.272.48.30178","article-title":"Importance of a novel oxidative mechanism for elimination of brain cholesterol. turnover of cholesterol and 24(s)- hydroxycholesterol in rat brain as measured with 18o2 techniques in vivo and in vitro.","volume":"272","author":"I Bj\u00f6rkhem","year":"1997","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3940(02)00164-7","article-title":"Cerebrospinal fluid 24 s-hydroxycholesterol is increased in patients with alzheimer&apos;s disease compared to healthy controls.","volume":"324","author":"P Sch\u00f6nknecht","year":"2002","journal-title":"Neurosci Lett"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1515\/CCLM.2004.034","article-title":"Diagnostic use of cerebral and extracerebral oxysterols.","volume":"42","author":"V Leoni","year":"2004","journal-title":"Clin Chem Lab Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(00)01466-X","article-title":"Plasma levels of 24shydroxycholesterol in patients with neurological diseases.","volume":"293","author":"L Bretillon","year":"2000","journal-title":"Neurosci Lett"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(03)00667-0","article-title":"Decreased levels of the brain specific 24 s-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients.","volume":"347","author":"CE Teunissen","year":"2003","journal-title":"Neurosci Lett"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/00001756-200006260-00030","article-title":"Plasma 24shydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for alzheimer&apos;s disease.","volume":"11","author":"A Papassotiropoulos","year":"2000","journal-title":"Neuroreport"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1471-4159.2009.06009.x","article-title":"25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase a2 type iia via lxr beta and pxr.","volume":"109","author":"A Trousson","year":"2009","journal-title":"J Neurochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/00001756-200506210-00007","article-title":"24 s-hydroxycholesterol induces inflammatory gene expression in primary human neural cells.","volume":"16","author":"P Alexandrov","year":"2005","journal-title":"Neuroreport"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/physrev.2000.80.1.361","article-title":"Oxysterols: modulators of cholesterol metabolism and other processes.","volume":"80","author":"GJ Schroepfer","year":"2000","journal-title":"Physiol Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(01)07184-7","article-title":"Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine.","volume":"358","author":"VP Valkonen","year":"2001","journal-title":"Lancet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jns.2009.12.020","article-title":"Asymmetric dimethylarginine (adma) as a possible risk marker for ischemic stroke.","volume":"290","author":"Y Nishiyama","year":"2010","journal-title":"J Neurol Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/ndt\/gfg452","article-title":"Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia.","volume":"18","author":"RJ Nijveldt","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"ref51","article-title":"Plasma dimethylarginines during the acute inflammatory response.","author":"S Blackwell","year":"2010","journal-title":"Eur J Clin Invest"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/cc1824","article-title":"Bench-to-bedside review: Cytopathic hypoxia.","volume":"6","author":"MP Fink","year":"2002","journal-title":"Crit Care"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"41391","DOI":"10.1074\/jbc.M110.174482","article-title":"Roles of sirt1 in the acute and restorative phases following induction of inflammation.","volume":"285","author":"Z Zhang","year":"2010","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/01.shk.0000235089.30550.2d","article-title":"Mitochondrial dysfunction, bioenergetic impairment, and metabolic downregulation in sepsis.","volume":"28","author":"RJ Levy","year":"2007","journal-title":"Shock"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0006-8993(82)91048-4","article-title":"An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.","volume":"247","author":"MN Perkins","year":"1982","journal-title":"Brain Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrd870","article-title":"Endogenous kynurenines as targets for drug discovery and development.","volume":"1","author":"TW Stone","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0304-3940(88)90813-0","article-title":"The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection.","volume":"90","author":"P Andin\u00e9","year":"1988","journal-title":"Neurosci Lett"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ab.2010.07.002","article-title":"Complexity and pitfalls of mass spectrometry-based targeted metabolomics in brain research.","volume":"406","author":"M Urban","year":"2010","journal-title":"Anal Biochem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e9606","DOI":"10.1371\/journal.pone.0009606","article-title":"Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs.","volume":"5","author":"R Solberg","year":"2010","journal-title":"PLoS One"},{"key":"ref60","article-title":"Fda guidance for industry: Bioanalytical method validation.","year":"2001"},{"key":"ref61","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-87458-6","article-title":"Mixed Effects Models and Extensions in Ecology with R.","author":"A Zuur","year":"2009"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing.","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.bi.53.070184.003533","article-title":"Polyamines.","volume":"53","author":"CW Tabor","year":"1984","journal-title":"Annu Rev Biochem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"11557","DOI":"10.1073\/pnas.94.21.11557","article-title":"The role of polyamine catabolism in polyamine analogue-induced programmed cell death.","volume":"94","author":"HC Ha","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.1987.tb05583.x","article-title":"Polyamines stimulate mitochondrial calcium transport in rat brain.","volume":"48","author":"JR Jensen","year":"1987","journal-title":"J Neurochem"},{"key":"ref66","first-page":"III98","article-title":"Brain polyamines are controlled by n-methyld- aspartate receptors during ischemia and recirculation.","volume":"21","author":"H Koenig","year":"1990","journal-title":"Stroke"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF03159973","article-title":"Polyamine metabolism in different pathological states of the brain.","volume":"16","author":"W Paschen","year":"1992","journal-title":"Mol Chem Neuropathol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1046\/j.1471-4159.2000.741106.x","article-title":"Elevated n1-acetylspermidine levels in gerbil and rat brains after cns injury.","volume":"74","author":"AM Rao","year":"2000","journal-title":"J Neurochem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1023\/A:1026123809033","article-title":"Ornithine decarboxylase activity in in vivo and in vitro models of cerebral ischemia.","volume":"28","author":"GN Babu","year":"2003","journal-title":"Neurochem Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(01)01538-5","article-title":"Spermidine\/spermine n1-acetyl transferase activity in rat brain following transient focal cerebral ischemia and reperfusion.","volume":"300","author":"GN Babu","year":"2001","journal-title":"Neurosci Lett"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1096\/fj.03-1203fje","article-title":"Neuroprotective effects of spermine following hypoxic-ischemic-induced brain damage: a mechanistic study.","volume":"18","author":"AN Clarkson","year":"2004","journal-title":"FASEB J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0029503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:03:03Z","timestamp":1742180583000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0029503"}},"subtitle":[],"editor":[{"given":"Patrick Ching-Ho","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,29]]},"references-count":71,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0029503","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,29]]}}}