{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:59:11Z","timestamp":1784257151589,"version":"3.55.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0029803","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T08:15:31Z","timestamp":1325751331000},"page":"e29803","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":92,"title":["Central Action of Peripherally Applied Botulinum Toxin Type A on Pain and Dural Protein Extravasation in Rat Model of Trigeminal Neuropathy"],"prefix":"10.1371","volume":"7","author":[{"given":"Boris","family":"Filipovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Matak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidija","family":"Bach-Rojecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdravko","family":"Lackovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2003.10.008","article-title":"Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.","volume":"107","author":"M Cui","year":"2004","journal-title":"Pain"},{"key":"ref2","first-page":"201","article-title":"Antinociceptive effect of botulinum toxin type A in rat model of the carrageenan and capsaicin induced pain.","volume":"46","author":"L Bach-Rojecky","year":"2005","journal-title":"Croat Med J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1472-8206.2008.00615.x","article-title":"Lack of anti-inflammatory effects of botulinum toxin A in experimental models of inflammation.","volume":"22","author":"L Bach-Rojecky","year":"2008","journal-title":"Fundam Clin Pharmacol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00702-004-0265-1","article-title":"Botulinum toxin type A in experimental neuropathic pain.","volume":"112","author":"L Bach-Rojecky","year":"2005","journal-title":"J Neural Transm"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF03022619","article-title":"The effects of botulinum toxin A on mechanical and cold allodynia in a rat model of neuropathic pain.","volume":"53","author":"HJ Park","year":"2006","journal-title":"Can J Anaesth"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2006.12.004","article-title":"Antiallodynic efficacy of botulinum neurotoxin A in a model of neuropathic pain.","volume":"145","author":"S Luvisetto","year":"2007","journal-title":"Neuroscience"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.neuroscience.2009.01.066","article-title":"Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction.","volume":"59","author":"Y Kitamura","year":"2009","journal-title":"Neuroscience"},{"key":"ref8","article-title":"Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay.","author":"A Kumada","year":"2011","journal-title":"J Oral Rehabil"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1472-8206.2009.00767.x","article-title":"Lasting reduction of postsurgical hyperalgesia after single injection of botulinum toxin type A in rat.","volume":"24","author":"B Filipovi\u0107","year":"2010","journal-title":"Fundam Clin Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.urology.2004.06.073","article-title":"Botulinum toxin A has antinociceptive effect in treating interstitial cystitis.","volume":"64","author":"CP Smith","year":"2004","journal-title":"Urology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.juro.2007.07.120","article-title":"Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat.","volume":"180","author":"YC Chuang","year":"2008","journal-title":"J Urol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pbb.2009.08.012","article-title":"Central origin of the antinociceptive action of botulinum toxin type A.","volume":"94","author":"L Bach-Rojecky","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2010.01.020","article-title":"Botulinum toxin type A reduces pain supersensitivity in experimental diabethic neuropathy: bilateral effects after unilateral injection.","volume":"633","author":"L Bach-Rojecky","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2009.06.047","article-title":"Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models.","volume":"617","author":"C Favre-Guilmard","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994","article-title":"Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve.","volume":"74","author":"BP Vos","year":"1994","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3959(01)00305-0","article-title":"Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain.","volume":"93","author":"D Christensen","year":"2001","journal-title":"Pain"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/sj.bjp.0704979","article-title":"The antimigraine 5-HT1B\/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.","volume":"137","author":"V Kayser","year":"2002","journal-title":"Br J Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2011.04.026","article-title":"Behavioral and immunohistochemical evidence for central antinociceptive activity of botulinum toxin A.","volume":"86","author":"I Matak","year":"2011","journal-title":"Neuroscience"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainresprot.2005.05.003","article-title":"Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy.","volume":"15","author":"JK Neubert","year":"2005","journal-title":"Brain Res Brain Res Protoc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/00220345730520024001","article-title":"A surgical approach to the ophthalmic-maxillary nerve trunks in the rat.","volume":"52","author":"JM Gregg","year":"1973","journal-title":"J Dent Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders like those seen in men.","volume":"33","author":"GJ Bennett","year":"1998","journal-title":"Pain"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/mvre.1993.1043","article-title":"A study of vasodilator responses evoked by antidromic stimulation of A delta afferent nerve fibers supplying normal and reinnervated rat skin.","volume":"46","author":"J Kolston","year":"1993","journal-title":"Microvasc Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0030-6665(03)00127-0","article-title":"Anatomy of headache and facial pain.","volume":"36","author":"D Larrier","year":"2003","journal-title":"Otolaryngol Clin North Am"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neubiorev.2003.12.003","article-title":"The orofacial formalin test.","volume":"28","author":"P Raboisson","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0304-3959(93)90151-E","article-title":"Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction.","volume":"55","author":"T Yamamoto","year":"1993","journal-title":"Pain"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1526-4637.2006.00197.x","article-title":"Imaging intracranial plasma extravasation in a migraine patient: a case report.","volume":"8","author":"H Knotkova","year":"2007","journal-title":"Pain Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/ana.410240607","article-title":"Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches.","volume":"24","author":"K Saito","year":"1988","journal-title":"Ann Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0014-2999(89)90719-X","article-title":"Indomethacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater.","volume":"165","author":"MG Buzzi","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1468-2982.1991.1104165.x","article-title":"Evidence for 5-HT1B\/1D receptors mediating the antimigraine effect of sumatriptan and dihydroergotamine.","volume":"11","author":"MG Buzzi","year":"1991","journal-title":"Cephalalgia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1476-5381.1995.tb16388.x","article-title":"Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation.","volume":"116","author":"WS Lee","year":"1995","journal-title":"Br J Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1177\/0333102410370873","article-title":"Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan.","volume":"30","author":"DL Nelson","year":"2010","journal-title":"Cephalalgia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0733-8619(18)30318-9","article-title":"Basic mechanisms in vascular headache.","volume":"8","author":"MA Moskowitz","year":"1990","journal-title":"Neurol Clin"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1523\/JNEUROSCI.07-12-04129.1987","article-title":"Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain.","volume":"7","author":"S Markowitz","year":"1987","journal-title":"J Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0306-4522(99)00388-7","article-title":"Functional cross-excitation between afferent A- and C-neurons in dorsal root ganglia.","volume":"95","author":"R Amir","year":"2000","journal-title":"Neuroscience"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1526-4610.2007.00854.x","article-title":"Neuron\u2013glia signaling in trigeminal ganglion: implications for migraine pathology.","volume":"47","author":"S Thalakoti","year":"2007","journal-title":"Headache"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1152\/jn.1998.79.2.964","article-title":"Chemical stimulation of intracranial dura induces enhanced responses to facial stimulation in brainstem trigeminal neurons.","volume":"79","author":"R Burstein","year":"1998","journal-title":"J Neurophysiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jn.1999.81.2.479","article-title":"Reduction of the threshold of cardiovascular and neuronal responses to facial and intracranial stimulation reflects central sensitization and cutaneous allodynia in a rat model of migraine.","volume":"81","author":"H Yamamura","year":"1999","journal-title":"J Neurophysiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0891-0618(01)00088-6","article-title":"Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanatomical link to generalized head pain.","volume":"21","author":"M Samsam","year":"2001","journal-title":"J Chem Neuroanat"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/08990229009144705","article-title":"Trigeminal projections to contralateral dorsal horn: central extent, peripheral origins, and plasticity.","volume":"7","author":"FM Jacquin","year":"1990","journal-title":"Somatosens Mot Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1523\/JNEUROSCI.0375-08.2008","article-title":"Long distance retrograde effects of botulinum neurotoxin A.","volume":"28","author":"F Antonucci","year":"2008","journal-title":"J Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1526-4610.2004.04007.x","article-title":"Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy.","volume":"44","author":"PL Durham","year":"2004","journal-title":"Headache"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1242\/jcs.012211","article-title":"Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential.","volume":"120","author":"J Meng","year":"2007","journal-title":"J Cell Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1523\/JNEUROSCI.5490-08.2009","article-title":"Activation of TRPV 1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential.","volume":"29","author":"J Meng","year":"2009","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0021-5155(99)00197-5","article-title":"Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles.","volume":"44","author":"H Ishikawa","year":"2000","journal-title":"Jpn J Ophtalmol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tips.2007.10.005","article-title":"CGRP antagonists: unraveling the role of CGRP in migraine.","volume":"28","author":"H Doods","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pharmthera.2009.09.003","article-title":"The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs.","volume":"124","author":"CM Villal\u00f3n","year":"2009","journal-title":"Pharmacol Ther"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0029803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T21:16:37Z","timestamp":1561151797000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0029803"}},"subtitle":[],"editor":[{"given":"Louis S.","family":"Premkumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,4]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0029803","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,4]]}}}