{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:39:20Z","timestamp":1778657960410,"version":"3.51.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T00:00:00Z","timestamp":1327276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030139","type":"journal-article","created":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T21:56:18Z","timestamp":1327355778000},"page":"e30139","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["CD40-Activated B Cells Can Efficiently Prime Antigen-Specific Na\u00efve CD8+ T Cells to Generate Effector but Not Memory T cells"],"prefix":"10.1371","volume":"7","author":[{"given":"M\u00e9lissa","family":"Mathieu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natacha","family":"Cotta-Grand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Daudelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salix","family":"Boulet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9jean","family":"Lapointe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Labrecque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0105-2896.2006.00382.x","article-title":"Signals required for programming effector and memory development by CD8+ T cells.","volume":"211","author":"MF Mescher","year":"2006","journal-title":"Immunol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1257","article-title":"Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.","volume":"11","author":"VP Badovinac","year":"2005","journal-title":"Nat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.4049\/jimmunol.175.7.4400","article-title":"IL-7 receptor expression levels do not identify CD8+ memory T lymphocyte precursors following peptide immunization.","volume":"175","author":"MH Lacombe","year":"2005","journal-title":"J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.","volume":"27","author":"NS Joshi","year":"2007","journal-title":"Immunity"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-1759(02)00429-5","article-title":"Single step enrichment of blood dendritic cells by positive immunoselection.","volume":"274","author":"JA Lopez","year":"2003","journal-title":"J Immunol Methods"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1084\/jem.175.1.131","article-title":"Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.","volume":"175","author":"EE Eynon","year":"1992","journal-title":"J Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/334253a0","article-title":"Can B cells turn on virgin T cells?","volume":"334","author":"O Lassila","year":"1988","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1084\/jem.177.3.679","article-title":"B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.","volume":"177","author":"F Ronchese","year":"1993","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.4049\/jimmunol.176.7.4012","article-title":"Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence.","volume":"176","author":"G Raimondi","year":"2006","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.4049\/jimmunol.176.7.4021","article-title":"Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation.","volume":"176","author":"G Raimondi","year":"2006","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.1439825","article-title":"B cells turn off virgin but not memory T cells.","volume":"258","author":"EJ Fuchs","year":"1992","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1084\/jem.179.1.249","article-title":"Tolerogenicity of resting and activated B cells.","volume":"179","author":"KM Gilbert","year":"1994","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.4049\/jimmunol.170.12.5897","article-title":"B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1.","volume":"170","author":"VV Parekh","year":"2003","journal-title":"J Immunol"},{"key":"ref14","first-page":"2836","article-title":"CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.","volume":"63","author":"R Lapointe","year":"2003","journal-title":"Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1172\/JCI119822","article-title":"CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy.","volume":"100","author":"JL Schultze","year":"1997","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1182\/blood.V99.9.3319","article-title":"Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.","volume":"99","author":"MS von Bergwelt-Baildon","year":"2002","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1182\/blood-2003-07-2379","article-title":"RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy.","volume":"103","author":"CM Coughlin","year":"2004","journal-title":"Blood"},{"key":"ref18","first-page":"137","article-title":"Autogeneic rna-electroporated CD40-ligand activated b-cells from hepatocellular carcinoma patients induce CD8+ T-cell responses ex vivo.","volume":"29","author":"S Shen","year":"2007","journal-title":"Exp Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2567.2007.02749.x","article-title":"CD40 Ligand-activated, antigen-specific B cells are comparable to mature dendritic cells in presenting protein antigens and major histocompatibility complex class I- and class II-binding peptides.","volume":"124","author":"T Ahmadi","year":"2008","journal-title":"Immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2249.2008.03820.x","article-title":"CD40-activated B cells can be generated in high number and purity in cancer patients: analysis of immunogenicity and homing potential.","volume":"155","author":"E Kondo","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1182\/blood-2004-01-0113","article-title":"CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants.","volume":"107","author":"M von Bergwelt-Baildon","year":"2006","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection.","volume":"76","author":"KA Hogquist","year":"1994","journal-title":"Cell"},{"key":"ref23","first-page":"7920","article-title":"Immunization against endogenous retroviral tumor-associated antigens.","volume":"61","author":"MH Kershaw","year":"2001","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2826::AID-IMMU2826>3.0.CO;2-M","article-title":"Dendritic cells need T cell help to prime cytotoxic T cell responses to strong antigens.","volume":"29","author":"AM Livingstone","year":"1999","journal-title":"Eur J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)80447-1","article-title":"Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody.","volume":"6","author":"A Porgador","year":"1997","journal-title":"Immunity"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1189\/jlb.0806494","article-title":"IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade.","volume":"82","author":"V Ostiguy","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.4049\/jimmunol.168.2.834","article-title":"Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1.","volume":"168","author":"RM Coles","year":"2002","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1128\/IAI.01088-06","article-title":"Cytosolic entry controls CD8+-T-cell potency during bacterial infection.","volume":"74","author":"KS Bahjat","year":"2006","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.","volume":"6","author":"AM Intlekofer","year":"2005","journal-title":"Nat Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e13740","DOI":"10.1371\/journal.pone.0013740","article-title":"Epitope density influences CD8 memory T cell differentiation.","volume":"5","author":"J Leignadier","year":"2010","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.80.7.2007","article-title":"Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences.","volume":"80","author":"DH Schulze","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/329512a0","article-title":"The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens.","volume":"329","author":"PJ Bjorkman","year":"1987","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.4049\/jimmunol.163.12.6462","article-title":"The in vivo fate of APCs displaying minor H antigen and\/or MHC differences is regulated by CTLs specific for immunodominant class I-associated epitopes.","volume":"163","author":"V Loyer","year":"1999","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11730","DOI":"10.1073\/pnas.0705007104","article-title":"Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection.","volume":"104","author":"TW Hand","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1084\/jem.20070841","article-title":"Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.","volume":"204","author":"AM Intlekofer","year":"2007","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.4049\/jimmunol.177.11.7515","article-title":"Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation.","volume":"177","author":"N Takemoto","year":"2006","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.4049\/jimmunol.1002042","article-title":"Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.","volume":"185","author":"A Banerjee","year":"2010","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2009.06.021","article-title":"Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses.","volume":"31","author":"A Kallies","year":"2009","journal-title":"Immunity"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2009.05.014","article-title":"Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.","volume":"31","author":"RL Rutishauser","year":"2009","journal-title":"Immunity"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/ni802","article-title":"Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells.","volume":"3","author":"H Ichii","year":"2002","journal-title":"Nat Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.173.2.883","article-title":"Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells.","volume":"173","author":"H Ichii","year":"2004","journal-title":"J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1359-6101(01)00038-7","article-title":"The roles of IFN gamma in protection against tumor development and cancer immunoediting.","volume":"13","author":"H Ikeda","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0952-7915(03)00007-4","article-title":"The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.","volume":"15","author":"T Blankenstein","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1074-7613(00)80218-6","article-title":"CD4+ T cell\u2013mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells.","volume":"12","author":"Z Qin","year":"2000","journal-title":"Immunity"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.immuni.2004.07.017","article-title":"The immunobiology of cancer immunosurveillance and immunoediting.","volume":"21","author":"GP Dunn","year":"2004","journal-title":"Immunity"},{"key":"ref46","first-page":"4095","article-title":"A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells.","volume":"63","author":"Z Qin","year":"2003","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.173.3.647","article-title":"Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes.","volume":"173","author":"RJ Barth Jr","year":"1991","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1002\/1521-4141(200009)30:9<2507::AID-IMMU2507>3.0.CO;2-V","article-title":"Differential requirement of perforin and IFN-gamma in CD8 T cell-mediated immune responses against B16.F10 melanoma cells expressing a viral antigen.","volume":"30","author":"A Prevost-Blondel","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/35074122","article-title":"IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.","volume":"410","author":"V Shankaran","year":"2001","journal-title":"Nature"},{"key":"ref50","first-page":"833","article-title":"gamma-Interferon plays a key role in T-cell-induced tumor regression.","volume":"53","author":"TM Tuttle","year":"1993","journal-title":"Cancer Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.4049\/jimmunol.168.7.3484","article-title":"Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin.","volume":"168","author":"N Seki","year":"2002","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nm1311","article-title":"T cells targeted against a single minor histocompatibility antigen can cure solid tumors.","volume":"11","author":"MC Meunier","year":"2005","journal-title":"Nat Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4049\/jimmunol.180.3.1309","article-title":"Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation.","volume":"180","author":"NS Joshi","year":"2008","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.4049\/jimmunol.0900968","article-title":"Cutting Edge: Importance of IL-6 and cooperation between innate and adaptive immune receptors in cellular vaccination with B lymphocytes.","volume":"183","author":"TJ Vanden Bush","year":"2009","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:15:28Z","timestamp":1686698128000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030139"}},"subtitle":[],"editor":[{"given":"J\u00f6rg Hermann","family":"Fritz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,23]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030139","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,23]]}}}