{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:47:56Z","timestamp":1794217676469,"version":"4.8.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030313","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T22:03:54Z","timestamp":1330466634000},"page":"e30313","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":227,"title":["Mesenchymal Transition and PDGFRA Amplification\/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas"],"prefix":"10.1371","volume":"7","author":[{"given":"Stephanie","family":"Puget","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorine A.","family":"Bax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Job","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Varlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Junier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Andreiuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Guerrini-Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Roujeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Dessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Richon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenael","family":"Le Teuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sainte-Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Geoerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Vassal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Grill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1002\/cncr.24663","article-title":"Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database.","volume":"115","author":"I Qaddoumi","year":"2009","journal-title":"Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1470-2045(06)70615-5","article-title":"Diffuse brainstem glioma in children: critical review of clinical trials.","volume":"7","author":"D Hargrave","year":"2006","journal-title":"The lancet oncology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1200\/JCO.2005.04.6599","article-title":"Advances toward an understanding of brainstem gliomas.","volume":"24","author":"SS Donaldson","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/pbc.21950","article-title":"Small molecule inhibitors in children with malignant gliomas.","volume":"53","author":"B Herrington","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijrobp.2009.04.031","article-title":"Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma.","volume":"77","author":"R Jalali","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1158\/1078-0432.CCR-10-0438","article-title":"A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.","volume":"16","author":"DA Bax","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/neuonc\/nop001","article-title":"Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas.","volume":"12","author":"HQ Qu","year":"2010","journal-title":"Neuro-oncology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1200\/JCO.2009.26.7252","article-title":"Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.","volume":"28","author":"BS Paugh","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/neuonc\/noq158","article-title":"Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas.","volume":"13","author":"J Barrow","year":"2011","journal-title":"Neuro Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1200\/JCO.2009.25.5463","article-title":"Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.","volume":"28","author":"M Zarghooni","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1227\/00006123-199312000-00010","article-title":"Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children&apos;s Cancer Group.","volume":"33","author":"AL Albright","year":"1993","journal-title":"Neurosurgery"},{"key":"ref12","first-page":"624","article-title":"Pontine glioma. To biopsy or not to biopsy: that is the question.","volume":"22","author":"D Hargrave","year":"2008","journal-title":"Brit J Neurosurg"},{"key":"ref13","first-page":"111","article-title":"Magnetic resonance imaging compared with biopsy in the diagnosis of brainstem diseases of childhood: a multicenter review.","volume":"106","author":"M Schumacher","year":"2007","journal-title":"J Neurosurg"},{"key":"ref14","first-page":"108","article-title":"Brainstem stereotactic biopsy sampling in children.","volume":"104","author":"DW Pincus","year":"2006","journal-title":"J Neurosurg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00005072-199309000-00009","article-title":"Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens.","volume":"52","author":"DN Louis","year":"1993","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref16","first-page":"3620","article-title":"ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma.","volume":"9","author":"RJ Gilbertson","year":"2003","journal-title":"Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11060-008-9566-9","article-title":"Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas.","volume":"88","author":"H Okada","year":"2008","journal-title":"J Neuro-oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1002\/cncr.25405","article-title":"Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma.","volume":"116","author":"A Broniscer","year":"2010","journal-title":"Cancer"},{"key":"ref19","first-page":"1","article-title":"Stereotactic biopsy of diffuse pontine lesions in children.","volume":"107","author":"T Roujeau","year":"2007","journal-title":"J Neurosurg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.ejca.2009.03.007","article-title":"Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium.","volume":"45","author":"B Geoerger","year":"2009","journal-title":"Eur J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/neuonc\/noq141","article-title":"Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing\/refractory brain tumors.","volume":"13","author":"B Geoerger","year":"2010","journal-title":"Neuro-oncology"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1109\/BIOTECHNO.2008.17","article-title":"Grouping levels of Exposure with same Observable Effects before Class Prediction in Toxicogenomics.","author":"V Guillemot","year":"2008"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad of Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.","volume":"17","author":"RG Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature08712","article-title":"The transcriptional network for mesenchymal transformation of brain tumours.","volume":"463","author":"MS Carro","year":"2010","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/1947601910373795","article-title":"The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-kappaB\/Snail\/RKIP\/PTEN Circuit.","volume":"1","author":"K Lin","year":"2010","journal-title":"Genes Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1158\/0008-5472.CAN-09-1851","article-title":"Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.","volume":"70","author":"JD Schiffman","year":"2010","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e16375","DOI":"10.1371\/journal.pone.0016375","article-title":"Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors.","volume":"6","author":"C Thirant","year":"2011","journal-title":"PLoS ONE"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/glia.20981","article-title":"Sox10 is necessary for oligodendrocyte survival following axon wrapping.","volume":"58","author":"N Takada","year":"2010","journal-title":"Glia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"21795","DOI":"10.1073\/pnas.1016485107","article-title":"Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.","volume":"107","author":"CD Pozniak","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/path.2450","article-title":"Oncogenic and ligand-dependent activation of KIT\/PDGFRA in surgical samples of imatinib-treated gastrointestinal stromal tumours (GISTs).","volume":"217","author":"T Negri","year":"2009","journal-title":"J Pathol"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"e20041","DOI":"10.1371\/journal.pone.0020041","article-title":"Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.","volume":"6","author":"L Lei","year":"2011","journal-title":"PLoS ONE"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.","volume":"28","author":"JD Cahoy","year":"2008","journal-title":"J Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1158\/0008-5472.CAN-07-0760","article-title":"Tumorigenesis in the brain: location, location, location.","volume":"67","author":"RJ Gilbertson","year":"2007","journal-title":"Cancer Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ccr.2005.09.001","article-title":"Radial glia cells are candidate stem cells of ependymoma.","volume":"8","author":"MD Taylor","year":"2005","journal-title":"Cancer Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1200\/JCO.2006.06.3701","article-title":"Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics.","volume":"24","author":"P Modena","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1002\/cncr.24476","article-title":"Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis.","volume":"115","author":"T Palm","year":"2009","journal-title":"Cancer"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/neuonc\/noq074","article-title":"Neuronal differentiation distinguishes supratentorial and infratentorial childhood ependymomas.","volume":"12","author":"F Andreiuolo","year":"2010","journal-title":"Neuro-oncology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/0008-5472.CAN-06-0973","article-title":"Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.","volume":"67","author":"MK Sharma","year":"2007","journal-title":"Cancer Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1038\/sj.onc.1210467","article-title":"Loss of suppressor-of-fused function promotes tumorigenesis.","volume":"26","author":"Y Lee","year":"2007","journal-title":"Oncogene"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.1101657108","article-title":"Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.","volume":"108","author":"M Monje","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref42","first-page":"354","article-title":"Thalamic tumors in children: a reappraisal.","volume":"106","author":"S Puget","year":"2007","journal-title":"J Neurosurg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ccr.2006.02.019","article-title":"Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.","volume":"9","author":"HS Phillips","year":"2006","journal-title":"Cancer Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.","volume":"444","author":"S Bao","year":"2006","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1476-4598-9-234","article-title":"An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients.","volume":"9","author":"F Ducray","year":"2010","journal-title":"Molecular Can"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1186\/1471-2407-10-605","article-title":"HIF-1alpha inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression.","volume":"10","author":"J Kessler","year":"2010","journal-title":"BMC Cancer"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bbrc.2010.03.092","article-title":"Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells.","volume":"394","author":"F Cao","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/1471-2407-10-454","article-title":"Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas.","volume":"10","author":"JL Garcia","year":"2010","journal-title":"BMC Cancer"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-009-9919-z","article-title":"Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors.","volume":"94","author":"Q Liu","year":"2009","journal-title":"J Neuro-oncol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/stem.154","article-title":"Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells.","volume":"27","author":"NK Kurrey","year":"2009","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1038\/onc.2010.185","article-title":"Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent.","volume":"29","author":"JT Lucas Jr","year":"2010","journal-title":"Oncogene"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1038\/onc.2010.218","article-title":"Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells.","volume":"29","author":"Y Wang","year":"2010","journal-title":"Oncogene"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1200\/JCO.2006.07.8626","article-title":"Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.","volume":"25","author":"D Faury","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e12548","DOI":"10.1371\/journal.pone.0012548","article-title":"The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas.","volume":"5","author":"LA Cooper","year":"2010","journal-title":"PloS ONE"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-4598-7-41","article-title":"Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile.","volume":"7","author":"F Ducray","year":"2008","journal-title":"Molecular Can"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1158\/0008-5472.CAN-04-0452","article-title":"Gene expression profiling of gliomas strongly predicts survival.","volume":"64","author":"WA Freije","year":"2004","journal-title":"Cancer Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09611","article-title":"Developmental genetics of vertebrate glial-cell specification.","volume":"468","author":"DH Rowitch","year":"2010","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ccr.2011.01.035","article-title":"The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.","volume":"19","author":"S Mehta","year":"2011","journal-title":"Cancer Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1056\/NEJMc090593","article-title":"IDH1 and IDH2 mutations in gliomas.","volume":"360","author":"E De Carli","year":"2009","journal-title":"New Engl J Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00381-010-1264-1","article-title":"IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children&apos;s Oncology Group.","volume":"27","author":"IF Pollack","year":"2011","journal-title":"Childs Nerv Syst"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1158\/1541-7786.MCR-07-0113","article-title":"Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B\u2013induced gliomagenesis.","volume":"5","author":"M Ferletta","year":"2007","journal-title":"Mol Cancer Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1038\/onc.2009.76","article-title":"Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma.","volume":"28","author":"N Lindberg","year":"2009","journal-title":"Oncogene"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ijc.24206","article-title":"PDGF-B induces a homogeneous class of oligodendrogliomas from embryonic neural progenitors.","volume":"124","author":"I Appolloni","year":"2009","journal-title":"Int J Cancer"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/glia.20986","article-title":"Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation.","volume":"58","author":"K Masui","year":"2010","journal-title":"Glia"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1158\/0008-5472.CAN-09-2503","article-title":"Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.","volume":"70","author":"OJ Becher","year":"2010","journal-title":"Cancer Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1371\/journal.pmed.0030485","article-title":"Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.","volume":"3","author":"JC Lee","year":"2006","journal-title":"PLoS medicine"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1101\/gad.1972310","article-title":"PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.","volume":"24","author":"T Ozawa","year":"2010","journal-title":"Genes Dev"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1215\/15228517-2006-031","article-title":"Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report.","volume":"9","author":"IF Pollack","year":"2007","journal-title":"Neuro-oncology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11060-009-0008-0","article-title":"Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme.","volume":"97","author":"M Holdhoff","year":"2010","journal-title":"J Neuro-oncol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1158\/1078-0432.CCR-06-0773","article-title":"Phase I\/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.","volume":"12","author":"PY Wen","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/ijc.25528","article-title":"Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma.","volume":"128","author":"J Paulsson","year":"2011","journal-title":"Int J Cancer"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bcmd.2004.11.006","article-title":"Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor.","volume":"34","author":"M Holdhoff","year":"2005","journal-title":"Blood Cells Mol Dis"},{"key":"ref73","first-page":"7377","article-title":"Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.","volume":"63","author":"JS Russell","year":"2003","journal-title":"Cancer Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1593\/tlo.09280","article-title":"Three paths to better tyrosine kinase inhibition behind the blood-brain barrier in treating chronic myelogenous leukemia and glioblastoma with imatinib.","volume":"3","author":"RE Kast","year":"2010","journal-title":"Translat Oncol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1158\/1078-0432.CCR-08-2253","article-title":"Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.","volume":"15","author":"JS Lagas","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref76","first-page":"287","article-title":"Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.","volume":"318","author":"JM Stommel","year":"2007"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1158\/1078-0432.CCR-08-3210","article-title":"EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines.","volume":"15","author":"DA Bax","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1101\/gr.5076506","article-title":"STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments.","volume":"16","author":"SJ Diskin","year":"2006","journal-title":"Genome Res"},{"key":"ref79","first-page":"414","article-title":"DR-Integrator: a new analytic tool for integrating DNA copy number and gene expression data.","volume":"26","author":"K Salari","year":"2010"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T21:31:40Z","timestamp":1713648700000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030313"}},"subtitle":[],"editor":[{"given":"Maciej S.","family":"Lesniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":79,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030313","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}