{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:30:56Z","timestamp":1773865856113,"version":"3.50.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T00:00:00Z","timestamp":1327276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030332","type":"journal-article","created":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T21:59:33Z","timestamp":1327355973000},"page":"e30332","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Heng","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita M.","family":"van den Hoek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo H.","family":"Reijmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan","family":"Wopereis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jildau","family":"Bouwman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Ramaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrie A. A. J.","family":"Korthout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vennik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hankemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Havekes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renger F.","family":"Witkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elwin R.","family":"Verheij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"van der Greef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0140-6736(10)62346-X","article-title":"Stemming the global tsunami of cardiovascular disease.","volume":"377","author":"SS Anand","year":"2011","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-2796.2008.01922.x","article-title":"The epidemiology of obesity: The size of the problem.","volume":"263","author":"WPT James","year":"2008","journal-title":"Journal of Internal Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0140-6736(09)60652-8","article-title":"Can the polypill save the world from heart disease?","volume":"373","author":"CP Cannon","year":"2009","journal-title":"The Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/MOL.0b013e32833305a3","article-title":"Polypill: the evidence and the promise.","volume":"20","author":"E Lonn","year":"2009","journal-title":"Current Opinion in Lipidology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/bmj.329.7480.1447","article-title":"The Polymeal: A more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.","volume":"329","author":"OH Franco","year":"2004","journal-title":"British Medical Journal"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tifs.2005.12.005","article-title":"The development of regulations of Chinese herbal medicines for both medicinal and food uses.","volume":"17","author":"CF Chau","year":"2006","journal-title":"Trends in Food Science and Technology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ptr.1624","article-title":"Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology.","volume":"19","author":"M Wang","year":"2005","journal-title":"Phytotherapy Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/ptr.2815","article-title":"The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart.","volume":"23","author":"J Bernatoniene","year":"2009","journal-title":"Phytotherapy Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1476-5381.2010.00826.x","article-title":"Emodin, a natural product, selectively inhibits 11\u03b2-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.","volume":"161","author":"Y Feng","year":"2010","journal-title":"British Journal of Pharmacology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1139\/o04-100","article-title":"Rose (Rosa rugosa)-flower extract increases the activities of antioxidant enzymes and their gene expression and reduces lipid peroxidation.","volume":"83","author":"TB Ng","year":"2005","journal-title":"Biochemistry & Cell Biology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7700","DOI":"10.1021\/jf801668c","article-title":"Anti-inflammatory, Gastroprotective, Free-Radical-Scavenging, and Antimicrobial Activities of Hawthorn Berries Ethanol Extract.","volume":"56","author":"VM Tadi\u0107","year":"2008","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.lfs.2003.09.064","article-title":"Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase.","volume":"74","author":"WX Tian","year":"2004","journal-title":"Life Sciences"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbalip.2008.12.008","article-title":"PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice.","volume":"1791","author":"W de Haan","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1161\/CIRCULATIONAHA.107.761965","article-title":"Torcetrapib Does Not Reduce Atherosclerosis Beyond Atorvastatin and Induces More Proinflammatory Lesions Than Atorvastatin.","volume":"117","author":"W de Haan","year":"2008","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2007.08.001","article-title":"Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice.","volume":"197","author":"W de Haan","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1161\/01.ATV.0000243925.65265.3c","article-title":"Cholesteryl Ester Transfer Protein Decreases High-Density Lipoprotein and Severely Aggravates Atherosclerosis in APOE*3-Leiden Mice.","volume":"26","author":"M Westerterp","year":"2006","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1476-5381.2008.00109.x","article-title":"The dual PPAR \u03b1\/\u03b3 agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice.","volume":"156","author":"JWA van der Hoorn","year":"2009","journal-title":"British Journal of Pharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1172\/JCI117117","article-title":"Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.","volume":"93","author":"BJ van Vlijmen","year":"1994","journal-title":"The Journal of Clinical Investigation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/ATVBAHA.107.142570","article-title":"Mouse Models for Atherosclerosis and Pharmaceutical Modifiers.","volume":"27","author":"S Zadelaar","year":"2007","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"ref20","first-page":"66","article-title":"Lipidomics and lipid profiling in metabolomics.","volume":"18","author":"JB German","year":"2007","journal-title":"Current Opinion in Lipidology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0022-2275(20)42785-3","article-title":"Synthetic low and high fat diets for the study of atherosclerosis in the mouse.","volume":"31","author":"PM Nishina","year":"1990","journal-title":"Journal of Lipid Research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11130-008-0102-z","article-title":"Extensive Screening for Plant Foodstuffs in Okinawa, Japan with Anti-Obese Activity on Adipocytes In Vitro.","volume":"64","author":"Y Niwano","year":"2009","journal-title":"Plant Foods for Human Nutrition (Formerly Qualitas Plantarum)"},{"key":"ref23","first-page":"493","article-title":"Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with oil red O.","volume":"97","author":"JL Ram\u00edrez-Zacar\u00edas","year":"1992","journal-title":"Histochemistry and Cell Biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2362.1999.00521.x","article-title":"Insulin decreases plasma cholesteryl ester transfer but not cholesterol esterification in healthy subjects as well as in normotriglyceridaemic patients with type 2 diabetes.","volume":"29","author":"RP Dullaart","year":"1999","journal-title":"European Journal of Clinical Investigation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1021\/pr800373m","article-title":"RPLC-Ion-Trap-FTMS Method for Lipid Profiling of Plasma: Method Validation and Application to p53 Mutant Mouse Model.","volume":"7","author":"C Hu","year":"2008","journal-title":"Journal of Proteome Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification.","volume":"37","author":"E Bligh","year":"1959","journal-title":"Canadian Journal of Biochemistry and Physiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1021\/pr0606530","article-title":"The Art and Practice of Systems Biology in Medicine:\u0393\u00c7\u00eb Mapping Patterns of Relationships.","volume":"6","author":"J van der Greef","year":"2007","journal-title":"Journal of Proteome Research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1021\/pr900499r","article-title":"Analytical Error Reduction Using Single Point Calibration for Accurate and Precise Metabolomic Phenotyping.","volume":"8","author":"FM van der Kloet","year":"2009","journal-title":"Journal of Proteome Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e4525","DOI":"10.1371\/journal.pone.0004525","article-title":"Metabolic Profiling of the Response to an Oral Glucose Tolerance Test Detects Subtle Metabolic Changes.","volume":"4","author":"S Wopereis","year":"2009","journal-title":"PLoS ONE"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/ac051495j","article-title":"Large-Scale Human Metabolomics Studies: A Strategy for Data (Pre-) Processing and Validation.","volume":"78","author":"S Bijlsma","year":"2005","journal-title":"Analytical Chemistry"},{"key":"ref31","article-title":"Handbook of Chemometrics and Qualimetrics: Part B","author":"B Vandeginste","year":"1998"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/cem.785","article-title":"Partial least squares for discrimination.","volume":"17","author":"M Barker","year":"2003","journal-title":"Journal of Chemometrics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.aca.2007.04.043","article-title":"Assessing the statistical validity of proteomics based biomarkers.","volume":"592","author":"S Smit","year":"2007","journal-title":"Analytica Chimica Acta"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e19423","DOI":"10.1371\/journal.pone.0019423","article-title":"Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice.","volume":"6","author":"C Hu","year":"2011","journal-title":"PLoS ONE"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/jbc.273.1.215","article-title":"Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro.","volume":"273","author":"MW Anthonsen","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"ref36","article-title":"Slimpid may boost plasma IGF-1 level and improve the quality of life in patients with risk of developing metabolic syndrome.","volume":"17","author":"SH Chui","year":"2008","journal-title":"Journal of Complementary and Integrative Medicine 5: number"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-8741(02)00059-4","article-title":"Medicinal plants of India with anti-diabetic potential.","volume":"81","author":"JK Grover","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"ref38","first-page":"CD003642","article-title":"Chinese herbal medicines for type 2 diabetes mellitus.","author":"JP Liu","year":"2004","journal-title":"Cochrane database of systematic reviews (Online)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/RHU.0b013e3181ba3926","article-title":"Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients.","volume":"15","author":"H Van Wietmarschen","year":"2009","journal-title":"Journal of Clinical Rheumatology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jep.2008.11.005","article-title":"Commentary: \u201cA systems view on the future of medicine: Inspiration from Chinese medicine?\u201d.","volume":"121","author":"R Verpoorte","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.1016\/B978-008045382-8.00063-0","article-title":"Biologically Active Compounds in Food Products and Their Effects on Obesity and Diabetes","author":"RF Witkamp","year":"2010"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.foodchem.2010.12.066","article-title":"Screening of selected Asian spices for anti obesity-related bioactivities.","volume":"126","author":"ND Yuliana","year":"2011","journal-title":"Food Chemistry"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.atherosclerosis.2009.02.038","article-title":"Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice.","volume":"206","author":"J de Vries-van der Weij","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1161\/ATVBAHA.108.171363","article-title":"Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE*3Leiden.CETP Mice.","volume":"28","author":"JWA van der Hoorn","year":"2008","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrd2775","article-title":"End of the line for cannabinoid receptor 1 as an anti-obesity target?","volume":"7","author":"D Jones","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0140-6736(07)61705-X","article-title":"Depression and anxiety with rimonabant.","volume":"370","author":"PB Mitchell","year":"2007","journal-title":"The Lancet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","article-title":"Effects of Torcetrapib in Patients at High Risk for Coronary Events.","volume":"357","author":"PJ Barter","year":"2007","journal-title":"New England journal of medicine"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.phrs.2007.03.002","article-title":"PPAR dual agonists: Are they opening Pandora's Box?","volume":"56","author":"P Balakumar","year":"2007","journal-title":"Pharmacological Research"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1007\/s11095-010-0341-1","article-title":"Current and Future Drug Targets in Weight Management.","volume":"28","author":"RF Witkamp","year":"2011","journal-title":"Pharmaceutical Research"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa044537","article-title":"Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia.","volume":"353","author":"JP Despres","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.299.13.1547","article-title":"Effect of Rimonabant on Progression of Atherosclerosis in Patients With Abdominal Obesity and Coronary Artery Disease: The STRADIVARIUS Randomized Controlled Trial.","volume":"299","author":"SE Nissen","year":"2008","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(05)66374-X","article-title":"Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study.","volume":"365","author":"LF Van Gaal","year":"2005","journal-title":"The Lancet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/mol.105.015040","article-title":"The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Cell Proliferation and Increases Markers of Adipocyte Maturation in Cultured Mouse 3T3 F442A Preadipocytes.","volume":"69","author":"M Gary-Bobo","year":"2006","journal-title":"Molecular Pharmacology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T20:16:24Z","timestamp":1640549784000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030332"}},"subtitle":[],"editor":[{"given":"Massimo","family":"Federici","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,23]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030332","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,23]]}}}